English
Custom Synthetic Intermediates
90259-27-1
Boiling point: 257.7±20.0 °C(Predicted)
Density: 1.258±0.06 g/cm3(Predicted)
Storage temp.: Sealed in dry,Room Temperature
Product Description
We are a pharmaceutical intermediate manufacturer of 2-Fluoro-6-methylbenzoic acid.
Its CAS No. is 90259-27-1
Our pharmaceutical intermediates can be used in a variety of APIs.
| Product Category | Custom Synthetic Intermediates |
| CAS NO | 90259-27-1 |
| Product Specifications | Boiling point: 257.7±20.0 °C(Predicted) Density: 1.258±0.06 g/cm3(Predicted) Storage temp.: Sealed in dry,Room Temperature |
Office Environment
Laboratory
Workshop/Warehouse
Certificate
2-Fluoro-6-methylbenzoic acid is produced by EASTFINE , and we are in charge of overseas selling . Not just trading compamy .
China,America,Brazil,England,Russia,Poland,India,Pakistan,NewZealand,Korea,Australia,Dubai,Turkey,Indonesia,UAE.
yes , you can have 1 2-Fluoro-6-methylbenzoic acid sample for starting the business , but it is not free
please contact sale team for detail .
2-Fluoro-6-methylbenzoic acid (CAS 90259-27-1) is a fluorinated aromatic carboxylic acid with molecular formula C₈H₇FO₂. This white to off-white crystalline solid features a unique substitution pattern with fluorine and methyl groups adjacent to the carboxyl group, making it particularly valuable for sterically demanding applications in pharmaceutical and material science.
The compound typically appears as white needle-like crystals with a molecular weight of 154.14 g/mol. It has a melting point range of 128-132°C and demonstrates moderate solubility in polar organic solvents like methanol and THF (20-50 mg/mL), while being poorly soluble in water (<1 mg/mL). The material exhibits good thermal stability and remains stable under normal storage conditions.
For optimal preservation, store in tightly sealed containers protected from moisture and light at room temperature. While stable under normal conditions, storage under inert atmosphere (nitrogen or argon) is recommended for long-term maintenance of high purity. Properly stored material shows no significant degradation for at least 36 months. Keep separated from strong bases and oxidizing agents.
This compound serves as a sterically hindered building block in medicinal chemistry, especially valuable for developing fluorinated pharmaceutical compounds where restricted rotation is desired. The carboxyl group enables various transformations while the adjacent substituents create unique steric effects. It's particularly useful in designing kinase inhibitors and liquid crystal materials.
The compound may cause mild irritation to skin, eyes and respiratory system. Appropriate personal protective equipment including nitrile gloves and chemical safety goggles should be worn. Use in a well-ventilated area and avoid dust formation. If contact occurs, flush affected areas with plenty of water for at least 15 minutes. Seek medical attention if irritation persists.
Quality control involves multiple analytical techniques including HPLC (typically ≥98% purity), melting point determination, and comprehensive spectroscopic analysis. FTIR confirms the carboxyl group presence, while ⊃1;H NMR shows characteristic splitting patterns from the adjacent fluorine. ⊃1;⁹F NMR and elemental analysis provide additional verification when required.
The steric crowding created by ortho-fluorine and ortho-methyl groups adjacent to the carboxyl moiety results in distinctive properties including restricted rotation, altered acidity, and directed reactivity patterns. This makes the compound especially valuable for creating conformationally constrained molecules in drug design and materials science.
This specialty chemical is available through fine chemical suppliers in quantities ranging from gram to kilogram scale. Reputable suppliers provide certificates of analysis with each batch and can offer technical support for specific applications. Custom synthesis and purification services are often available for specialized research needs.
