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Custom Synthetic Intermediates
2646-90-4
Melting point: 67-69 °C
Boiling point: 67-69 °C/17 mmHg (lit.)
Density: 1.308 g/mL at 25 °C (lit.)
Storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
Product Description
We are a pharmaceutical intermediate manufacturer of 2,5-Difluorobenzaldehyde.
Its CAS No. is 2646-90-4
Our pharmaceutical intermediates can be used in a variety of APIs.
| Product Category | Custom Synthetic Intermediates |
| CAS NO | 2646-90-4 |
| Product Specifications | Melting point: 67-69 °C Boiling point: 67-69 °C/17 mmHg (lit.) Density: 1.308 g/mL at 25 °C (lit.) Storage temp.: under inert gas (nitrogen or Argon) at 2-8°C |
Office Environment
Laboratory
Workshop/Warehouse
Certificate
2,5-Difluorobenzaldehyde is produced by EASTFINE , and we are in charge of overseas selling . Not just trading compamy .
China,America,Brazil,England,Russia,Poland,India,Pakistan,NewZealand,Korea,Australia,Dubai,Turkey,Indonesia,UAE.
yes , you can have 1 2,5-Difluorobenzaldehyde sample for starting the business , but it is not free
please contact sale team for detail .
2,5-Difluorobenzaldehyde (CAS 2646-90-4) is a difluorinated aromatic aldehyde with molecular formula C₇H₄F₂O. This colorless to pale yellow liquid contains two fluorine atoms at the ortho and meta positions relative to the formyl group, making it a valuable building block for pharmaceutical and materials chemistry applications.
The compound appears as a clear, colorless to slightly yellow liquid with a characteristic aromatic odor. It has a molecular weight of 142.10 g/mol, boiling point of 85-88°C at 25 mmHg, and density of approximately 1.28 g/cm³ at 25°C. The material shows good solubility in common organic solvents but limited water solubility.
For optimal stability, store in tightly sealed amber glass containers under inert atmosphere (nitrogen or argon) at 2-8°C. The aldehyde group is sensitive to oxidation, so containers should be purged before sealing. Properly stored material maintains excellent stability for at least 24 months when protected from light and moisture.
This compound serves as a key intermediate in medicinal chemistry, particularly for developing fluorinated drug candidates. The aldehyde group enables various condensation reactions, while the fluorine atoms enhance metabolic stability. It's especially valuable in synthesizing kinase inhibitors, CNS drugs, and liquid crystal materials.
The material may cause skin and eye irritation. Use appropriate PPE including nitrile gloves and safety goggles, and handle only in a fume hood. Avoid inhalation of vapors and direct contact. In case of exposure, flush affected areas with water for 15 minutes. The compound is combustible and should be kept away from ignition sources.
Quality control includes GC analysis (typically ≥98% purity), refractive index measurement (n20/D ~1.47), and spectroscopic methods. FTIR confirms the aldehyde carbonyl stretch (~1685 cm⁻⊃1;), while ⊃1;H and ⊃1;⁹F NMR provide structural verification. Mass spectrometry may be used for molecular weight confirmation.
The difluoro substitution pattern creates unique electronic properties that enhance both reactivity and stability. The fluorine atoms activate the aldehyde toward nucleophilic attack while improving the metabolic stability of derivatives. This combination makes it particularly useful for designing bioactive molecules.
The compound is available through specialty chemical suppliers in quantities ranging from grams to kilograms. Many suppliers provide certificates of analysis with each batch and can accommodate custom synthesis requests. Technical support is typically available for specific application questions.
