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Custom Synthetic Intermediates
328-73-4
Boiling point: 59-61 °C/10 mmHg (lit.)
Density: 1.919 g/mL at 25 °C(lit.)
Storage temp.: Keep in dark place,Sealed in dry,Room Temperature
Product Description
We are a pharmaceutical intermediate manufacturer of 1-Iodo-3,5-Bis(Trifluoromethyl)Benzene.
Its CAS No. is 328-73-4
Our pharmaceutical intermediates can be used in a variety of APIs.
| Product Category | Custom Synthetic Intermediates |
| CAS NO | 328-73-4 |
| Product Specifications | Boiling point: 59-61 °C/10 mmHg (lit.) Density: 1.919 g/mL at 25 °C(lit.) Storage temp.: Keep in dark place,Sealed in dry,Room Temperature |
Office Environment
Laboratory
Workshop/Warehouse
Certificate
1-Iodo-3,5-Bis(Trifluoromethyl)Benzene is produced by EASTFINE , and we are in charge of overseas selling . Not just trading compamy .
China,America,Brazil,England,Russia,Poland,India,Pakistan,NewZealand,Korea,Australia,Dubai,Turkey,Indonesia,UAE.
yes , you can have 1 1-Iodo-3,5-Bis(Trifluoromethyl)Benzene sample for starting the business , but it is not free
please contact sale team for detail .
1-Iodo-3,5-bis(trifluoromethyl)benzene (CAS 328-73-4) is a polyfluorinated aromatic compound with molecular formula C₈H₃F₆I. This colorless to pale yellow liquid features an iodine atom flanked by two strongly electron-withdrawing trifluoromethyl groups, making it an exceptionally reactive intermediate for coupling reactions in pharmaceutical and materials chemistry.
The compound typically appears as a colorless to light yellow liquid with a molecular weight of 315.91 g/mol. It has a boiling point range of 95-100°C at 15 mmHg and a density of approximately 1.98 g/cm³ at 25°C. The material demonstrates excellent solubility in common organic solvents like dichloromethane and ether, while being insoluble in water. It solidifies at temperatures below 15°C.
For optimal stability, store in tightly sealed amber glass containers under inert atmosphere (nitrogen or argon) at 2-8°C. The material is light-sensitive and should be protected from prolonged exposure. Properly stored, it maintains excellent stability for at least 12 months. Keep away from strong oxidizers, reducing agents, and reactive metals.
This compound serves as a premium building block in medicinal chemistry, particularly valuable for Sonogashira, Suzuki-Miyaura, and other palladium-catalyzed cross-coupling reactions. The electron-deficient aromatic system activates the iodine for efficient coupling, while the trifluoromethyl groups enhance both reactivity and metabolic stability. It's especially useful in developing fluorinated pharmaceuticals and electronic materials.
The compound may cause severe skin burns and eye damage. Appropriate personal protective equipment including chemical-resistant gloves (Viton® or silver shield), face shield, and proper ventilation are essential. Handle only in a fume hood and avoid any contact with skin or eyes. In case of exposure, immediately flush affected areas with copious amounts of water for at least 15 minutes and seek medical attention.
Quality control includes GC analysis (typically ≥98% purity), refractive index measurement (n20/D ~1.47), and comprehensive spectroscopic characterization. ⊃1;H NMR shows a characteristic singlet for the aromatic proton, while ⊃1;⁹F NMR confirms the trifluoromethyl groups. Mass spectrometry provides molecular weight confirmation, and iodine content may be verified by elemental analysis.
The symmetric 1,3,5-substitution pattern creates an extremely electron-deficient aromatic system that significantly enhances the reactivity of the iodine in coupling reactions. This property, combined with the lipophilicity and metabolic stability imparted by the trifluoromethyl groups, makes it ideal for constructing advanced pharmaceutical intermediates and functional materials.
This high-value fluorinated building block is available through specialty chemical suppliers in quantities ranging from grams to kilograms. Reputable suppliers provide detailed certificates of analysis with each batch, including chromatographic purity data and spectral characterization. Custom synthesis and purification services are often available for specific research requirements.
