EASTFINE is a specialized manufacturer of 1-Iodo-3,5-bis(trifluoromethyl)benzene, a high-purity highly fluorinated aromatic compound (C8H3F6I).3 This molecule is a critical synthetic intermediate and building block renowned for its extreme electron-deficiency due to the presence of two strong -CF3 groups. This property, combined with the reactive C-I bond, makes it invaluable in synthesizing complex pharmaceuticals, agrochemicals, and advanced electronic materials where strong meta electron-withdrawing effects are required. Our product is supplied as a colorless to light yellow liquid requiring cold, dark storage.
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328-73-4
Custom Synthesis and Sourcing
1-Iodo-3,5-bis(trifluoromethyl)benzene
C8H3F6I
368.01 g/mol
Colorless to Light Yellow Liquid
Not Available (Liquid at RT)
187 ∘C
1.862 g/cm3 (Predicted)
Store at 2-8℃ or below, sealed in dry, dark place, under inert atmosphere.
200L Galvanized Drum
Contact us for Customized Packaging
Please contact us
Product Description
EASTFINE is a leading supplier of 1-Iodo-3,5-bis(trifluoromethyl)benzene, a core building block in modern chemical synthesis. The symmetric placement of the two trifluoromethyl (-CF3) groups at the 3 and 5 positions creates a pronounced electron-deficient aromatic ring. Its primary utility lies in forming new carbon skeletons through various cross-coupling reactions (e.g., Suzuki, Sonogashira), enabling chemists to construct complex aromatic scaffolds with the essential high lipophilicity and metabolic stability provided by the -CF3 groups.
At EASTFINE, our 328-73-4 intermediate is produced under rigorous quality control to guarantee its purity and optimal reactivity for high-yield synthetic processes.
CAS No. | 328-73-4 |
Category | Custom Synthesis and Sourcing |
Name | 1-Iodo-3,5-bis(trifluoromethyl)benzene |
Molecular Formula | C8H3F6I |
Molecular Weight | 368.01 g/mol |
Chemical Structure | |
Form | Colorless to Light Yellow Liquid |
Melting Point | Not Available (Liquid at RT) |
Boiling Point | 187 ∘C |
Density | 1.862 g/cm3 (Predicted) |
Storage Temperature | Store at 2-8℃ or below, sealed in dry, dark place, under inert atmosphere. |
Packaging | 200L Galvanized Drum |
Contact us for Customized Packaging | |
MSDS document |
As a dedicated 328-73-4 manufacturer, EASTFINE ensures a stable and high-quality supply. Our synthetic procedures are optimized to deliver product purity of min. 97%, which is critical for preventing side reactions in sensitive catalytic coupling methodologies. Due to the compound's sensitivity to light and its classification as an organoiodide, our material is meticulously packaged and shipped under controlled, dark conditions, and we strongly recommend cold storage (2-8℃) under an inert atmosphere to maintain product integrity and chemical reactivity over time.
The presence of two trifluoromethyl (-CF3) groups at the meta positions makes this aromatic ring highly electron-deficient (or super-electron-deficient). This property dramatically changes the reactivity profile of the ring, particularly promoting nucleophilic aromatic substitution (SNAr) if a suitable leaving group were present. In this compound, the high electron-deficiency is crucial for influencing the electronic properties of the coupled group in the final product, often resulting in increased metabolic stability and unique properties in materials science.
1-Iodo-3,5-bis(trifluoromethyl)benzene is a liquid that can cause skin and eye irritation. Standard personal protective equipment must be used during handling. Due to its C-I bond and its liquid form, it is sensitive to light and oxygen. To maintain high purity and stability, the manufacturer recommends storage in a cool, dark place (preferably 2-8℃), tightly sealed under an inert atmosphere (such as argon or nitrogen) to prevent degradation and loss of material due to oxidation or evaporation.
This compound is used as a core building block in the synthesis of specialized aromatic scaffolds. It is crucial for creating meta-substituted biphenyls, triarylamines, and heterocyclic systems where the bis(trifluoromethyl)phenyl group is needed to impart high lipophilicity, strong electron-withdrawing character, and metabolic resistance. These properties are essential in high-performance organic semiconductors and complex pharmaceutical and agrochemical structures.
Established in 1995, EASTFINE has evolved into a leading enterprise in the production of fine and specialty chemicals. As a dedicated 328-73-4 1-Iodo-3,5-bis(trifluoromethyl)benzene manufacturer, we are committed to providing reliable solutions for a diverse range of industries. Our company operates on the core principles of honesty, professionalism, and collaboration, which guide our interactions with a global client base spanning Asia, America, and Europe. We strive to be a trusted partner in providing high-quality chemical intermediates.
The EASTFINE team consists of highly skilled technical experts and customer-focused sales professionals. We are committed to providing exceptional service and comprehensive technical support for products like 328-73-4 1-Iodo-3,5-bis(trifluoromethyl)benzene. Our team proactively manages logistics, quality assurance documentation, and regulatory compliance to ensure a smooth and efficient procurement process. We aim to build long-term partnerships based on mutual trust and support.
EASTFINE’s manufacturing strength for products like 328-73-4 1-Iodo-3,5-bis(trifluoromethyl)benzene is built on a flexible and efficient model. This combines the capabilities of our own dedicated production base with strategically managed outsourced processing, allowing us to meet a wide range of order sizes. Our manufacturing processes adhere to GMP-LIKE standards, and we are committed to continuous investment in technology to enhance purity and yield, ensuring consistent quality for all our products.
At EASTFINE, our advanced R&D system is focused on creating new synthesis routes and improving existing processes for products like 328-73-4 1-Iodo-3,5-bis(trifluoromethyl)benzene. Our state-of-the-art pilot and Kilo-Lab facilities allow for a seamless transition from laboratory research to commercial production. Quality assurance is integrated into every stage of our R&D process, ensuring that quality is built into the product from its inception.
Our business is driven by a core set of values that define our approach to every project, including the supply of 328-73-4 1-Iodo-3,5-bis(trifluoromethyl)benzene.
EASTFINE is committed to a robust culture of intellectual property (IP) protection. As a 328-73-4 1-Iodo-3,5-bis(trifluoromethyl)benzene manufacturer, we understand the importance of safeguarding confidential synthesis routes and proprietary information. Our active patent portfolio, which includes 19 invention patents and 8 utility model patents, is a testament to our dedication to innovation. This strong IP framework ensures we can handle your most sensitive projects with complete confidentiality and professionalism.
EASTFINE aims to leverage its global presence and logistics network to support reliable and efficient delivery of 328-73-4 1-Iodo-3,5-bis(trifluoromethyl)benzene to clients across Asia, America, and Europe. Our approach to supply chain management, combined with strategic warehousing and a dual manufacturing method, is designed to provide consistent supply and support on-time delivery, seeking to minimize any potential disruptions for your operations.
To accommodate our diverse international client base, EASTFINE offers flexible payment methods. While specific terms can be discussed upon quotation, we generally accept common secure payment options such as bank transfers (T/T). Our sales team is ready to discuss mutually agreeable payment solutions for your 328-73-4 1-Iodo-3,5-bis(trifluoromethyl)benzene order.
Yes, customized synthesis and OEM services are key offerings at EASTFINE. As a 328-73-4 1-Iodo-3,5-bis(trifluoromethyl)benzene manufacturer, our dedicated Custom Synthesis Department, backed by our advanced R&D and production base, is equipped to provide comprehensive support. Whether you require a specialized variant of this chemical or other unique compounds, we aim to offer solutions including logistics, quality control, and new product development tailored to your specific project needs.
Yes, EASTFINE operates with transparency and welcomes client audits. Our production of pharmaceutical intermediates, including 328-73-4 1-Iodo-3,5-bis(trifluoromethyl)benzene, strives to comply with GMP-LIKE requirements. We aim to build trust through openness and are prepared to demonstrate our adherence to quality and operational considerations during your audit process.
Yes, EASTFINE is an active participant in industry events to connect with our global clients and showcase our advancements. We regularly attend CPHI (Convention on Pharmaceutical Ingredients), both domestically and internationally each year. These exhibitions provide an opportunity for face-to-face discussions about your needs for 328-73-4 1-Iodo-3,5-bis(trifluoromethyl)benzene and other chemical solutions, and to explore potential collaborations.
We understand the importance of product evaluation before a large order. To ensure our clients' confidence, samples from our 328-73-4 1-Iodo-3,5-bis(trifluoromethyl)benzene manufacturer are available upon request. Please note that samples are provided on a non-gratis basis. To arrange for a sample of our product and discuss the specific terms, please contact our sales team directly.
EASTFINE is a brand built on a foundation of professional dedication and humble service since 1995. We aim to be a trusted, long-term partner in the fine chemical industry. Our brand identity is defined by our commitment to providing reliable, high-quality products like 328-73-4 1-Iodo-3,5-bis(trifluoromethyl)benzene, supported by technical expertise and ethical business practices.
Our sales team is focused on building sincere and lasting relationships. We prioritize clear, timely, and effective communication throughout the entire process, from initial inquiry to post-delivery support. Our approach is collaborative and transparent, aiming to provide you with a professional and straightforward experience as your partner for 328-73-4 1-Iodo-3,5-bis(trifluoromethyl)benzene and other intermediates.
We view client complaints as opportunities for continuous improvement. EASTFINE is committed to a structured and transparent process for addressing all feedback. We take all complaints seriously, investigate them thoroughly, and work to implement corrective actions to ensure full compliance and client satisfaction. Our goal is to resolve issues quickly and effectively, upholding our core value of responsibility.
Continuous improvement is a core principle of our QA framework. Our Quality Assurance team is involved from the earliest R&D stages, and their oversight continues throughout production. We regularly review our processes against GMP-LIKE standards, incorporating feedback and new technologies to consistently enhance the quality and reliability of our products, including 328-73-4 1-Iodo-3,5-bis(trifluoromethyl)benzene. This expresses our determination to meet and exceed client expectations.
As a responsible chemical enterprise, EASTFINE is committed to operating in an environmentally conscious manner. We strive to implement sustainable practices in our production processes to minimize our ecological footprint. Our dedication to social responsibility is a key part of our "Sustainable Development" core value, reflecting our commitment to the well-being of our community and the planet.
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