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Custom Synthetic Intermediates
13194-67-7
Boiling point: 92-94 °C15 mm Hg(lit.)
Density: 1.752 g/mL at 25 °C(lit.)
Flash point: 188 °F
Storage temp.: Keep in dark place,Sealed in dry,Room Temperature
Product Description
We are a pharmaceutical intermediate manufacturer of 4-Fluoro-2-Iodotoluene.
Its CAS No. is 13194-67-7
Our pharmaceutical intermediates can be used in a variety of APIs.
| Product Category | Custom Synthetic Intermediates |
| CAS NO | 13194-67-7 |
| Product Specifications | Boiling point: 92-94 °C15 mm Hg(lit.) Density: 1.752 g/mL at 25 °C(lit.) Flash point: 188 °F Storage temp.: Keep in dark place,Sealed in dry,Room Temperature |
Office Environment
Laboratory
Workshop/Warehouse
Certificate
4-Fluoro-2-Iodotoluene is produced by EASTFINE , and we are in charge of overseas selling . Not just trading compamy .
China,America,Brazil,England,Russia,Poland,India,Pakistan,NewZealand,Korea,Australia,Dubai,Turkey,Indonesia,UAE.
yes , you can have 1 4-Fluoro-2-Iodotoluene sample for starting the business , but it is not free
please contact sale team for detail .
4-Fluoro-2-iodotoluene (CAS 13194-67-7) is a halogenated aromatic compound with molecular formula C₇H₆FI. This pale yellow to amber liquid features a fluorine atom at the para position and an iodine atom at the ortho position relative to the methyl group, serving as a versatile intermediate for pharmaceutical synthesis and cross-coupling reactions.
The compound typically appears as a light yellow to amber colored liquid with a molecular weight of 236.03 g/mol. It has a boiling point of approximately 105-110°C at 15 mmHg and a density of about 1.9 g/cm³ at 25°C. The material shows good solubility in common organic solvents like dichloromethane and ether, but is insoluble in water.
For optimal stability, store in tightly sealed amber glass containers under inert atmosphere (nitrogen or argon) at 2-8°C. The material is light-sensitive and should be protected from prolonged exposure. Properly stored, it maintains excellent stability for at least 12 months. Keep away from strong oxidizers and reducing agents.
This compound serves as a valuable building block in medicinal chemistry, particularly for Suzuki-Miyaura and other palladium-catalyzed cross-coupling reactions. The iodine substituent enables efficient coupling while the fluorine enhances metabolic stability. It's especially useful in developing fluorinated pharmaceutical compounds and PET imaging agents.
The compound may cause skin and eye irritation. Appropriate personal protective equipment including nitrile gloves and chemical safety goggles should be worn. Handle only in a fume hood with adequate ventilation. Avoid inhalation of vapors and direct contact. In case of exposure, flush affected areas immediately with plenty of water.
Quality control includes GC analysis (typically ≥97% purity), refractive index measurement (n20/D ~1.58), and comprehensive spectroscopic characterization. ⊃1;H NMR and ⊃1;⁹F NMR provide structural verification, while mass spectrometry confirms molecular weight. Iodine content may be verified by elemental analysis for critical applications.
The strategic combination of fluorine and iodine substituents creates unique reactivity where the iodine enables efficient cross-coupling while the fluorine provides electronic tuning of the aromatic system. This makes the compound particularly valuable for constructing complex fluorinated architectures in drug discovery.
This specialty chemical is commercially available through fine chemical suppliers in quantities ranging from grams to kilograms. Many suppliers provide certificates of analysis with each batch and can accommodate custom synthesis requests. Technical support is typically available for specific application development questions.
