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Custom Synthetic Intermediates
452-82-4
Boiling point: 122-125 °C/30 mmHg (lit.)
Density: 1.833 g/mL at 25 °C (lit.)
Flash point: 140 °F
Storage temp.: 2-8°C(protect from light)
Product Description
We are a pharmaceutical intermediate manufacturer of 4-Fluoro-3-Iodotoluene.
Its CAS No. is 452-82-4
Our pharmaceutical intermediates can be used in a variety of APIs.
| Product Category | Custom Synthetic Intermediates |
| CAS NO | 452-82-4 |
| Product Specifications | Boiling point: 122-125 °C/30 mmHg (lit.) Density: 1.833 g/mL at 25 °C (lit.) Flash point: 140 °F Storage temp.: 2-8°C(protect from light) |
Office Environment
Laboratory
Workshop/Warehouse
Certificate
4-Fluoro-3-Iodotoluene is produced by EASTFINE , and we are in charge of overseas selling . Not just trading compamy .
China,America,Brazil,England,Russia,Poland,India,Pakistan,NewZealand,Korea,Australia,Dubai,Turkey,Indonesia,UAE.
yes , you can have 1 4-Fluoro-3-Iodotoluene sample for starting the business , but it is not free
please contact sale team for detail .
4-Fluoro-3-iodotoluene (CAS 452-82-4) is a halogenated aromatic compound with molecular formula C₇H₆FI. This pale yellow to amber liquid features a fluorine atom at the para position and an iodine atom at the meta position relative to the methyl group, serving as a versatile intermediate for pharmaceutical synthesis and transition metal-catalyzed coupling reactions.
The compound typically appears as a light yellow to amber colored liquid with a molecular weight of 236.03 g/mol. It has a boiling point range of 110-115°C at 15 mmHg and a density of approximately 1.88 g/cm³ at 25°C. The material demonstrates excellent solubility in common organic solvents like dichloromethane and THF, while being insoluble in water.
For optimal stability, store in tightly sealed amber glass containers under inert atmosphere (nitrogen or argon) at 2-8°C. The material is sensitive to both light and air exposure, requiring protection from these elements. Properly stored, it maintains excellent stability for at least 12 months. Keep away from strong oxidizing agents and reducing metals.
This compound serves as a premium building block in medicinal chemistry, particularly valuable for Suzuki-Miyaura cross-coupling reactions to create fluorinated biaryl structures. The iodine substituent enables efficient coupling while the fluorine enhances metabolic stability of resulting compounds. It's especially useful in developing kinase inhibitors and PET radiotracer precursors.
The compound may cause skin irritation and serious eye damage. Appropriate personal protective equipment including chemical-resistant gloves (nitrile or neoprene), safety goggles, and proper ventilation are essential. Handle only in a fume hood and avoid inhalation of vapors or mist. In case of contact, immediately flush affected areas with copious amounts of water for at least 15 minutes.
Quality assessment includes GC analysis (typically ≥97% purity), refractive index measurement (n20/D ~1.57), and comprehensive spectroscopic characterization. ⊃1;H NMR shows characteristic aromatic proton patterns, while ⊃1;⁹F NMR confirms the fluorine substitution. Mass spectrometry provides molecular weight confirmation, and iodine content may be verified by elemental analysis.
The meta-iodo/para-fluoro substitution pattern creates unique electronic properties where the iodine enables efficient cross-coupling while the fluorine provides both electronic tuning of the aromatic system and enhanced metabolic stability. This combination makes the compound particularly valuable for constructing complex fluorinated architectures in drug discovery.
This specialty chemical is available through fine chemical suppliers in quantities ranging from grams to kilograms. Reputable suppliers provide certificates of analysis with each batch, including chromatographic purity data and spectral characterization. Custom synthesis and purification services are often available for specific research requirements, along with technical support for application development.
