≥98%
37777-76-7
Custom Synthesis and Sourcing
2-Chloro-6-fluorophenylacetic acid
C8H6ClFO2
188.58 g/mol
White to Off-White Crystalline Powder
121-125℃
292 ∘C
1.439 g/cm3 (Predicted)
Store sealed in a dry, cool, dark place.
25KG Cardboard Drum
Contact us for Customized Packaging
Please contact us
Product Description
EASTFINE is a leading supplier of 2-Chloro-6-fluorophenylacetic acid, a core building block in modern chemical synthesis. The molecule features a reactive carboxylic acid group (-COOH) attached to the benzene ring via a methylene (-CH2) spacer, which is often used for coupling reactions. The ortho-chloro and ortho-fluoro substitution pattern on the aromatic ring is strategically placed to create steric hindrance and electronic modulation, properties critical for directing selectivity in subsequent coupling reactions and ensuring the desired biological activity in the final drug product, Diclofenac.
At EASTFINE, our 37777-76-7 intermediate is produced under rigorous quality control to guarantee its purity and optimal reactivity for high-yield synthetic processes.
CAS No. | 37777-76-7 |
Category | Custom Synthesis and Sourcing |
Name | 2-Chloro-6-fluorophenylacetic acid |
Molecular Formula | C8H6ClFO2 |
Molecular Weight | 188.58 g/mol |
Chemical Structure |  |
Form | White to Off-White Crystalline Powder |
Melting Point | 121-125℃ |
Boiling Point | 292 ∘C |
Density | 1.439 g/cm3 (Predicted) |
Storage Temperature | Store sealed in a dry, cool, dark place. |
Packaging | 25KG Cardboard Drum |
Contact us for Customized Packaging | |
 | |
MSDS document |
As a dedicated 37777-76-7 manufacturer, EASTFINE ensures a stable and high-quality supply. Our material is optimized to deliver product purity of min. 98%, which is crucial for achieving high yield and minimizing impurities in the subsequent cyclization and coupling steps required to synthesize Diclofenac. As a stable carboxylic acid derivative, it is packaged as a crystalline solid and requires sealed, dry storage at ambient conditions.
2-Chloro-6-fluorophenylacetic acid is the crucial C8 fragment used to form the backbone of the NSAID Diclofenac. The primary synthetic step involves coupling the -NH2 group of a 2,6-dichloroaniline derivative with the -COOH group of the phenylacetic acid to form an amide linkage. Subsequent cyclization closes the indole ring. The ortho-chloro and ortho-fluoro groups are positioned to facilitate the final ring formation and impart the necessary structural rigidity and electronic properties for Diclofenac's pharmacological activity.
The 2-chloro-6-fluoro substitution pattern provides unique steric and electronic effects. The bulky ortho substituents (Cl and F) are critical in the synthesis of Diclofenac as they force the phenyl rings to adopt a non-planar (twisted) conformation after coupling. This twisted geometry is believed to be essential for the drug's effectiveness as it optimizes its binding profile to the Cyclooxygenase (COX) enzyme, thereby maximizing its anti-inflammatory activity.
Yes, the carboxylic acid group (-COOH) is highly versatile. It can be easily activated or converted to various derivatives, such as the corresponding acid chloride (-COCl), ester (-COOR), or amide (-CONH2). This reactivity is essential in the synthesis of Diclofenac, where it is often converted to an amide through a coupling reaction with an amine (Ar-NH2) in the first major step.
Established in 1995, EASTFINE has evolved into a leading enterprise in the production of fine and specialty chemicals. As a dedicated 37777-76-7 2-Chloro-6-fluorophenylacetic acid manufacturer, we are committed to providing reliable solutions for a diverse range of industries. Our company operates on the core principles of honesty, professionalism, and collaboration, which guide our interactions with a global client base spanning Asia, America, and Europe. We strive to be a trusted partner in providing high-quality chemical intermediates.
The EASTFINE team consists of highly skilled technical experts and customer-focused sales professionals. We are committed to providing exceptional service and comprehensive technical support for products like 37777-76-7 2-Chloro-6-fluorophenylacetic acid. Our team proactively manages logistics, quality assurance documentation, and regulatory compliance to ensure a smooth and efficient procurement process. We aim to build long-term partnerships based on mutual trust and support.
EASTFINE’s manufacturing strength for products like 37777-76-7 2-Chloro-6-fluorophenylacetic acid is built on a flexible and efficient model. This combines the capabilities of our own dedicated production base with strategically managed outsourced processing, allowing us to meet a wide range of order sizes. Our manufacturing processes adhere to GMP-LIKE standards, and we are committed to continuous investment in technology to enhance purity and yield, ensuring consistent quality for all our products.
At EASTFINE, our advanced R&D system is focused on creating new synthesis routes and improving existing processes for products like 37777-76-7 2-Chloro-6-fluorophenylacetic acid. Our state-of-the-art pilot and Kilo-Lab facilities allow for a seamless transition from laboratory research to commercial production. Quality assurance is integrated into every stage of our R&D process, ensuring that quality is built into the product from its inception.
Our business is driven by a core set of values that define our approach to every project, including the supply of 37777-76-7 2-Chloro-6-fluorophenylacetic acid.
EASTFINE is committed to a robust culture of intellectual property (IP) protection. As a 37777-76-7 2-Chloro-6-fluorophenylacetic acid manufacturer, we understand the importance of safeguarding confidential synthesis routes and proprietary information. Our active patent portfolio, which includes 19 invention patents and 8 utility model patents, is a testament to our dedication to innovation. This strong IP framework ensures we can handle your most sensitive projects with complete confidentiality and professionalism.
EASTFINE aims to leverage its global presence and logistics network to support reliable and efficient delivery of 37777-76-7 2-Chloro-6-fluorophenylacetic acid to clients across Asia, America, and Europe. Our approach to supply chain management, combined with strategic warehousing and a dual manufacturing method, is designed to provide consistent supply and support on-time delivery, seeking to minimize any potential disruptions for your operations.
To accommodate our diverse international client base, EASTFINE offers flexible payment methods. While specific terms can be discussed upon quotation, we generally accept common secure payment options such as bank transfers (T/T). Our sales team is ready to discuss mutually agreeable payment solutions for your 37777-76-7 2-Chloro-6-fluorophenylacetic acid order.
Yes, customized synthesis and OEM services are key offerings at EASTFINE. As a 37777-76-7 2-Chloro-6-fluorophenylacetic acid manufacturer, our dedicated Custom Synthesis Department, backed by our advanced R&D and production base, is equipped to provide comprehensive support. Whether you require a specialized variant of this chemical or other unique compounds, we aim to offer solutions including logistics, quality control, and new product development tailored to your specific project needs.
Yes, EASTFINE operates with transparency and welcomes client audits. Our production of pharmaceutical intermediates, including 37777-76-7 2-Chloro-6-fluorophenylacetic acid, strives to comply with GMP-LIKE requirements. We aim to build trust through openness and are prepared to demonstrate our adherence to quality and operational considerations during your audit process.
Yes, EASTFINE is an active participant in industry events to connect with our global clients and showcase our advancements. We regularly attend CPHI (Convention on Pharmaceutical Ingredients), both domestically and internationally each year. These exhibitions provide an opportunity for face-to-face discussions about your needs for 37777-76-7 2-Chloro-6-fluorophenylacetic acid and other chemical solutions, and to explore potential collaborations.
We understand the importance of product evaluation before a large order. To ensure our clients' confidence, samples from our 37777-76-7 2-Chloro-6-fluorophenylacetic acid manufacturer are available upon request. Please note that samples are provided on a non-gratis basis. To arrange for a sample of our product and discuss the specific terms, please contact our sales team directly.
EASTFINE is a brand built on a foundation of professional dedication and humble service since 1995. We aim to be a trusted, long-term partner in the fine chemical industry. Our brand identity is defined by our commitment to providing reliable, high-quality products like 37777-76-7 2-Chloro-6-fluorophenylacetic acid, supported by technical expertise and ethical business practices.
Our sales team is focused on building sincere and lasting relationships. We prioritize clear, timely, and effective communication throughout the entire process, from initial inquiry to post-delivery support. Our approach is collaborative and transparent, aiming to provide you with a professional and straightforward experience as your partner for 37777-76-7 2-Chloro-6-fluorophenylacetic acid and other intermediates.
We view client complaints as opportunities for continuous improvement. EASTFINE is committed to a structured and transparent process for addressing all feedback. We take all complaints seriously, investigate them thoroughly, and work to implement corrective actions to ensure full compliance and client satisfaction. Our goal is to resolve issues quickly and effectively, upholding our core value of responsibility.
Continuous improvement is a core principle of our QA framework. Our Quality Assurance team is involved from the earliest R&D stages, and their oversight continues throughout production. We regularly review our processes against GMP-LIKE standards, incorporating feedback and new technologies to consistently enhance the quality and reliability of our products, including 37777-76-7 2-Chloro-6-fluorophenylacetic acid. This expresses our determination to meet and exceed client expectations.
As a responsible chemical enterprise, EASTFINE is committed to operating in an environmentally conscious manner. We strive to implement sustainable practices in our production processes to minimize our ecological footprint. Our dedication to social responsibility is a key part of our "Sustainable Development" core value, reflecting our commitment to the well-being of our community and the planet.
简体中文
