EASTFINE is a specialized manufacturer of 4-FluoroBenzyl bromide (1-(bromomethyl)-4-fluorobenzene), a high-purity fluorinated aromatic alkylating agent (C7H6BrF). This molecule is a critical synthetic intermediate and building block prized for the high reactivity of its benzyl bromide (-CH2Br) group, which allows for the facile introduction of the para-fluorobenzyl structural unit. This unit is highly valuable in synthesizing complex molecules, particularly for pharmaceutical and agrochemical development, where the C-F bond in the para position is commonly used to optimize a molecule's electronic properties and enhance its metabolic stability. Our product is supplied as a white to pale yellow crystalline solid or low-melting solid requiring cold, dark storage.
≥98%
459-46-1
Custom Synthesis and Sourcing
4-FluoroBenzyl bromide
C7H6BrF
189.02 g/mol
White to Pale Yellow Crystalline Solid
30-33℃
191-192 ∘C
1.492 g/cm3 (Predicted)
Store at 2-8℃ or below, sealed in dry, dark place, under inert atmosphere.
200L Galvanized Drum
Contact us for Customized Packaging
Please contact us
Product Description
EASTFINE is a leading supplier of 4-FluoroBenzyl bromide, a core building block in modern chemical synthesis. Its defining feature is the high reactivity of the benzyl bromide moiety, which readily undergoes substitution reactions with nucleophiles (e.g., amines, alcohols, thiols) to efficiently install the 4-fluorobenzyl unit. This intermediate is essential for synthesizing molecules where the fluorine atom is required at the para position to achieve a desirable balance of electronic and metabolic stability properties in the final product. This makes it a standard reagent for developing complex organic frameworks in the fine chemical industry.
At EASTFINE, our 459-46-1 intermediate is produced under rigorous quality control to guarantee its purity and optimal reactivity for high-yield synthetic processes.
CAS No. | 459-46-1 |
Category | Custom Synthesis and Sourcing |
Name | 4-FluoroBenzyl bromide |
Molecular Formula | C7H6BrF |
Molecular Weight | 189.02 g/mol |
Chemical Structure |  |
Form | White to Pale Yellow Crystalline Solid |
Melting Point | 30-33℃ |
Boiling Point | 191-192 ∘C |
Density | 1.492 g/cm3 (Predicted) |
Storage Temperature | Store at 2-8℃ or below, sealed in dry, dark place, under inert atmosphere. |
Packaging | 200L Galvanized Drum |
Contact us for Customized Packaging | |
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MSDS document |
As a dedicated 459-46-1 manufacturer, EASTFINE ensures a stable and high-quality supply. Our material is optimized to deliver product purity of min. 98%, which is crucial for high efficiency in alkylation reactions. The highly reactive nature of the benzyl bromide group means this compound is sensitive to moisture and light. Therefore, EASTFINE implements specialized packaging and cold storage logistics (2-8℃) under an inert atmosphere to protect the material from degradation and maintain its reactivity.
The fluorine atom is situated at the para position to the benzylic substitution site. At this position, the fluorine exerts its strongest electron-withdrawing inductive effect on the C-H bonds of the aromatic ring, slightly stabilizing adjacent functional groups. Most critically in medicinal chemistry, the 4-fluorobenzyl scaffold is a ubiquitous motif used to significantly increase lipophilicity and metabolic stability (preventing rapid oxidation) in the final drug candidate, often leading to improved bioavailability.
4-FluoroBenzyl bromide is a hazardous material that must be handled with extreme care. Due to the benzyl bromide functional group, it is classified as a lachrymator (causes tears and eye irritation) and causes severe skin burns and eye damage (H314). Handling must take place in a well-ventilated fume hood using appropriate personal protective equipment (PPE). It must be stored tightly sealed in a cool, dark place (2-8℃), protected from moisture and light, ideally under an inert atmosphere to prevent decomposition and the formation of irritating HBr.
The melting point of 30-33℃ means that 4-FluoroBenzyl bromide is a low-melting solid that is often encountered as a liquid at slightly elevated room temperatures, or a solid in cold storage. This dual nature affects its handling and dispensing. While it is stored as a solid to maintain stability, chemists may warm it slightly to use it as a liquid for easier measurement and transfer in synthesis, distinguishing it from isomers that are pure liquids (like the 2- and 3-fluoro isomers) or high-melting solids.
Established in 1995, EASTFINE has evolved into a leading enterprise in the production of fine and specialty chemicals. As a dedicated 459-46-1 4-FluoroBenzyl bromide manufacturer, we are committed to providing reliable solutions for a diverse range of industries. Our company operates on the core principles of honesty, professionalism, and collaboration, which guide our interactions with a global client base spanning Asia, America, and Europe. We strive to be a trusted partner in providing high-quality chemical intermediates.
The EASTFINE team consists of highly skilled technical experts and customer-focused sales professionals. We are committed to providing exceptional service and comprehensive technical support for products like 459-46-1 4-FluoroBenzyl bromide. Our team proactively manages logistics, quality assurance documentation, and regulatory compliance to ensure a smooth and efficient procurement process. We aim to build long-term partnerships based on mutual trust and support.
EASTFINE’s manufacturing strength for products like 459-46-1 4-FluoroBenzyl bromide is built on a flexible and efficient model. This combines the capabilities of our own dedicated production base with strategically managed outsourced processing, allowing us to meet a wide range of order sizes. Our manufacturing processes adhere to GMP-LIKE standards, and we are committed to continuous investment in technology to enhance purity and yield, ensuring consistent quality for all our products.
At EASTFINE, our advanced R&D system is focused on creating new synthesis routes and improving existing processes for products like 459-46-1 4-FluoroBenzyl bromide. Our state-of-the-art pilot and Kilo-Lab facilities allow for a seamless transition from laboratory research to commercial production. Quality assurance is integrated into every stage of our R&D process, ensuring that quality is built into the product from its inception.
Our business is driven by a core set of values that define our approach to every project, including the supply of 459-46-1 4-FluoroBenzyl bromide.
EASTFINE is committed to a robust culture of intellectual property (IP) protection. As a 459-46-1 4-FluoroBenzyl bromide manufacturer, we understand the importance of safeguarding confidential synthesis routes and proprietary information. Our active patent portfolio, which includes 19 invention patents and 8 utility model patents, is a testament to our dedication to innovation. This strong IP framework ensures we can handle your most sensitive projects with complete confidentiality and professionalism.
EASTFINE aims to leverage its global presence and logistics network to support reliable and efficient delivery of 459-46-1 4-FluoroBenzyl bromide to clients across Asia, America, and Europe. Our approach to supply chain management, combined with strategic warehousing and a dual manufacturing method, is designed to provide consistent supply and support on-time delivery, seeking to minimize any potential disruptions for your operations.
To accommodate our diverse international client base, EASTFINE offers flexible payment methods. While specific terms can be discussed upon quotation, we generally accept common secure payment options such as bank transfers (T/T). Our sales team is ready to discuss mutually agreeable payment solutions for your 459-46-1 4-FluoroBenzyl bromide order.
Yes, customized synthesis and OEM services are key offerings at EASTFINE. As a 459-46-1 4-FluoroBenzyl bromide manufacturer, our dedicated Custom Synthesis Department, backed by our advanced R&D and production base, is equipped to provide comprehensive support. Whether you require a specialized variant of this chemical or other unique compounds, we aim to offer solutions including logistics, quality control, and new product development tailored to your specific project needs.
Yes, EASTFINE operates with transparency and welcomes client audits. Our production of pharmaceutical intermediates, including 459-46-1 4-FluoroBenzyl bromide, strives to comply with GMP-LIKE requirements. We aim to build trust through openness and are prepared to demonstrate our adherence to quality and operational considerations during your audit process.
Yes, EASTFINE is an active participant in industry events to connect with our global clients and showcase our advancements. We regularly attend CPHI (Convention on Pharmaceutical Ingredients), both domestically and internationally each year. These exhibitions provide an opportunity for face-to-face discussions about your needs for 459-46-1 4-FluoroBenzyl bromide and other chemical solutions, and to explore potential collaborations.
We understand the importance of product evaluation before a large order. To ensure our clients' confidence, samples from our 459-46-1 4-FluoroBenzyl bromide manufacturer are available upon request. Please note that samples are provided on a non-gratis basis. To arrange for a sample of our product and discuss the specific terms, please contact our sales team directly.
EASTFINE is a brand built on a foundation of professional dedication and humble service since 1995. We aim to be a trusted, long-term partner in the fine chemical industry. Our brand identity is defined by our commitment to providing reliable, high-quality products like 459-46-1 4-FluoroBenzyl bromide, supported by technical expertise and ethical business practices.
Our sales team is focused on building sincere and lasting relationships. We prioritize clear, timely, and effective communication throughout the entire process, from initial inquiry to post-delivery support. Our approach is collaborative and transparent, aiming to provide you with a professional and straightforward experience as your partner for 459-46-1 4-FluoroBenzyl bromide and other intermediates.
We view client complaints as opportunities for continuous improvement. EASTFINE is committed to a structured and transparent process for addressing all feedback. We take all complaints seriously, investigate them thoroughly, and work to implement corrective actions to ensure full compliance and client satisfaction. Our goal is to resolve issues quickly and effectively, upholding our core value of responsibility.
Continuous improvement is a core principle of our QA framework. Our Quality Assurance team is involved from the earliest R&D stages, and their oversight continues throughout production. We regularly review our processes against GMP-LIKE standards, incorporating feedback and new technologies to consistently enhance the quality and reliability of our products, including 459-46-1 4-FluoroBenzyl bromide. This expresses our determination to meet and exceed client expectations.
As a responsible chemical enterprise, EASTFINE is committed to operating in an environmentally conscious manner. We strive to implement sustainable practices in our production processes to minimize our ecological footprint. Our dedication to social responsibility is a key part of our "Sustainable Development" core value, reflecting our commitment to the well-being of our community and the planet.
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