143418-49-9 3,4,5-Trifluorophenylboronic acid

143418-49-9 3,4,5-Trifluorophenylboronic acid Introduction

We are a pharmaceutical intermediate manufacturer of 3,4,5-Trifluorophenylboronic acid.

Its CAS No. is 143418-49-9

Our pharmaceutical intermediates can be used in a variety of APIs.

143418-49-9 3,4,5-Trifluorophenylboronic acid Specifications

143418-49-9 3,4,5-Trifluorophenylboronic acid Factory display

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143418-49-9 3,4,5-Trifluorophenylboronic acid Certification

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143418-49-9 3,4,5-Trifluorophenylboronic acid FAQ

1. Manufacturer or trading company for 143418-49-9 3,4,5-Trifluorophenylboronic acid?

3,4,5-Trifluorophenylboronic acid is produced by EASTFINE , and we are in charge of overseas selling . Not just trading compamy .

2. 143418-49-9 3,4,5-Trifluorophenylboronic acid supplier and factories or wholesale locates in such countries like?

China,America,Brazil,England,Russia,Poland,India,Pakistan,NewZealand,Korea,Australia,Dubai,Turkey,Indonesia,UAE.

3. Can I get a sample for trying 143418-49-9 3,4,5-Trifluorophenylboronic acid?

yes , you can have 1 3,4,5-Trifluorophenylboronic acid sample for starting the business , but it is not free

4. What the MOQ of 143418-49-9 3,4,5-Trifluorophenylboronic acid?

please contact sale team for detail .

5. What is 3,4,5-Trifluorophenylboronic acid?

3,4,5-Trifluorophenylboronic acid (CAS 143418-49-9) is a fluorinated organoboron compound with molecular formula C₆H₄BF₃O₂. This white crystalline solid features a boronic acid group on a perfluorinated aromatic ring, making it an exceptionally reactive and valuable reagent for Suzuki-Miyaura cross-coupling reactions in pharmaceutical and materials chemistry.

6. What are the physical properties?

The compound appears as a white to off-white crystalline powder with a molecular weight of 175.90 g/mol. It has a melting point range of 210-215°C (with decomposition) and demonstrates good solubility in polar aprotic solvents like DMSO and THF, though limited solubility in water and non-polar solvents. The material is stable at room temperature but may gradually discolor upon prolonged exposure to moisture.

7. How should this compound be stored?

For maximum stability, store in airtight containers with desiccants under inert atmosphere (nitrogen or argon) at 2-8°C. The boronic acid functionality is highly moisture-sensitive, requiring strict protection from humidity. Under optimal conditions, the material maintains excellent stability for at least 24 months. Keep away from strong oxidizers and bases.

8. What are its primary synthetic applications?

This compound serves as a premium building block for introducing trifluorinated aromatic systems into drug molecules through Suzuki couplings. The electron-deficient aromatic ring enhances reactivity in cross-coupling reactions while the fluorine atoms improve metabolic stability and membrane permeability of resulting compounds. It's particularly valuable in developing CNS drugs, kinase inhibitors, and liquid crystal materials.

9. What safety precautions should be observed?

While not highly toxic, the compound may cause skin and eye irritation. Use appropriate PPE including nitrile gloves, safety goggles, and proper ventilation. Avoid inhalation of dust and direct contact. In case of exposure, flush affected areas with water for 15 minutes. The material is stable under normal handling conditions but may decompose at elevated temperatures.

10. How is purity typically verified?

Quality control includes HPLC analysis (typically ≥97% purity), melting point determination, and comprehensive spectroscopic characterization. ⊃1;H NMR shows the characteristic aromatic proton pattern, while ⊃1;⊃1;B and ⊃1;⁹F NMR confirm the boronic acid and fluorine substituents respectively. Elemental analysis may be used for additional verification.

11. What makes this compound chemically valuable?

The symmetric trifluoro substitution pattern creates an extremely electron-deficient aromatic system that significantly enhances the reactivity of the boronic acid in coupling reactions. This property, combined with the metabolic stability imparted by the fluorine atoms, makes it ideal for constructing advanced pharmaceutical intermediates and functional materials.

12. Where can researchers obtain this chemical?

This high-value reagent is available through specialty chemical suppliers in quantities ranging from milligrams to kilograms. Many suppliers provide certificates of analysis with each batch and offer custom synthesis services. Technical support is typically available for specific application development and process optimization questions.