374790-98-4 2-Fluoro-4-Iodophenylboronic Acid

374790-98-4 2-Fluoro-4-Iodophenylboronic Acid Introduction

We are a pharmaceutical intermediate manufacturer of 2-Fluoro-4-Iodophenylboronic Acid.

Its CAS No. is 374790-98-4

Our pharmaceutical intermediates can be used in a variety of APIs.

374790-98-4 2-Fluoro-4-Iodophenylboronic Acid Specifications

374790-98-4 2-Fluoro-4-Iodophenylboronic Acid Factory display

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Laboratory

Workshop/Warehouse

374790-98-4 2-Fluoro-4-Iodophenylboronic Acid Certification

Certificate

374790-98-4 2-Fluoro-4-Iodophenylboronic Acid FAQ

1. Manufacturer or trading company for 374790-98-4 2-Fluoro-4-Iodophenylboronic Acid?

2-Fluoro-4-Iodophenylboronic Acid is produced by EASTFINE , and we are in charge of overseas selling . Not just trading compamy .

2. 374790-98-4 2-Fluoro-4-Iodophenylboronic Acid supplier and factories or wholesale locates in such countries like?

China,America,Brazil,England,Russia,Poland,India,Pakistan,NewZealand,Korea,Australia,Dubai,Turkey,Indonesia,UAE.

3. Can I get a sample for trying 374790-98-4 2-Fluoro-4-Iodophenylboronic Acid?

yes , you can have 1 2-Fluoro-4-Iodophenylboronic Acid sample for starting the business , but it is not free

4. What the MOQ of 374790-98-4 2-Fluoro-4-Iodophenylboronic Acid?

please contact sale team for detail .

5. What is 2-Fluoro-4-iodophenylboronic acid?

2-Fluoro-4-iodophenylboronic acid (CAS 374790-98-4) is a halogenated organoboron compound with molecular formula C₆H₅BFIO₂. This off-white to beige crystalline solid features a reactive boronic acid group adjacent to both fluorine and iodine substituents on the aromatic ring, making it particularly valuable for transition metal-catalyzed cross-coupling reactions in pharmaceutical synthesis.

6. What are the key physical properties?

The compound typically appears as an off-white to light beige powder with a molecular weight of 265.82 g/mol. It has a melting point range of 180-185°C (with decomposition) and shows moderate solubility in polar aprotic solvents like DMF and THF, though limited solubility in water and non-polar solvents. The material is air-stable but should be protected from prolonged light exposure.

7. How should this reagent be stored?

For optimal stability, store in amber glass containers with desiccants under inert atmosphere (nitrogen or argon) at 2-8°C. The boronic acid group is moisture-sensitive, so containers should be tightly sealed and protected from humidity. Under these conditions, the material maintains excellent stability for at least 18 months. Keep away from strong oxidizing agents.

8. What are its primary synthetic applications?

This compound serves as a versatile building block in medicinal chemistry, especially for constructing fluorinated and iodinated biaryl structures through Suzuki-Miyaura couplings. The iodine substituent enables additional transformations via halogen exchange reactions, while the fluorine enhances metabolic stability in drug candidates. It's particularly valuable in developing kinase inhibitors and PET imaging agents.

9. What safety precautions are necessary?

The material may cause mild skin and eye irritation. Appropriate PPE including nitrile gloves and safety goggles should be worn during handling. Avoid inhalation of dust and work in a well-ventilated area. While not highly toxic, ingestion should be avoided. In case of exposure, flush affected areas with water. The compound is stable under normal laboratory conditions.

10. How is purity typically verified?

Quality control includes HPLC analysis (typically ≥95% purity), melting point determination, and spectroscopic characterization. ⊃1;H NMR confirms the aromatic proton pattern, while ⊃1;⊃1;B NMR verifies the boronic acid functionality. Mass spectrometry provides molecular weight confirmation. Iodine content may be verified by elemental analysis.

11. What makes this compound chemically valuable?

The unique combination of substituents creates multiple advantages: the iodine enables versatile cross-coupling and conversion to other functionalities, the fluorine enhances electronic properties and metabolic stability, while the boronic acid facilitates efficient biaryl formation. This trifunctional nature makes it exceptionally useful for constructing complex pharmaceutical intermediates.

12. Where can this chemical be obtained?

This specialty reagent is commercially available through fine chemical suppliers in quantities ranging from milligrams to kilograms. Many suppliers provide certificates of analysis with each batch and can accommodate custom synthesis requests. Technical support is typically available for specific application development questions.