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Custom Synthetic Intermediates
83506-93-8
Melting point: 181-185 °C
Boiling point: 326.8±42.0 °C(Predicted)
Density: 1.536±0.06 g/cm3(Predicted)
Storage temp.: Keep in dark place,Inert atmosphere,Room temperature
Product Description
We are a pharmaceutical intermediate manufacturer of 2-Amino-4,5-difluorobenzoic acid.
Its CAS No. is 83506-93-8
Our pharmaceutical intermediates can be used in a variety of APIs.
| Product Category | Custom Synthetic Intermediates |
| CAS NO | 83506-93-8 |
| Product Specifications | Melting point: 181-185 °C Boiling point: 326.8±42.0 °C(Predicted) Density: 1.536±0.06 g/cm3(Predicted) Storage temp.: Keep in dark place,Inert atmosphere,Room temperature |
Office Environment
Laboratory
Workshop/Warehouse
Certificate
2-Amino-4,5-difluorobenzoic acid is produced by EASTFINE , and we are in charge of overseas selling . Not just trading compamy .
China,America,Brazil,England,Russia,Poland,India,Pakistan,NewZealand,Korea,Australia,Dubai,Turkey,Indonesia,UAE.
yes , you can have 1 2-Amino-4,5-difluorobenzoic acid sample for starting the business , but it is not free
please contact sale team for detail .
2-Amino-4,5-difluorobenzoic acid (CAS 83506-93-8) is a fluorinated aromatic compound with molecular formula C₇H₅F₂NO₂. This off-white to light brown crystalline solid features an amino group and carboxylic acid functionality on a difluorinated benzene ring, making it a valuable intermediate in pharmaceutical and agrochemical synthesis.
The compound typically appears as a light tan to beige crystalline powder with a molecular weight of 173.12 g/mol. It has a melting point range of 195-200°C and demonstrates moderate solubility in polar organic solvents like DMSO and methanol, though limited solubility in water. The material is stable at room temperature but may gradually darken upon prolonged exposure to air and light.
For maximum stability, store in tightly sealed containers protected from light and moisture at room temperature. While relatively stable, storage under inert atmosphere (nitrogen or argon) is recommended for long-term preservation. Properly stored material maintains excellent stability for at least 24 months. Keep away from strong oxidizing agents and bases.
This trifunctional compound serves as a key building block in medicinal chemistry, particularly for developing difluorinated pharmaceutical compounds. The amino group enables various derivatization reactions, while the carboxylic acid allows for esterification or coupling reactions. It's especially valuable in designing kinase inhibitors and CNS-active drugs.
The compound may cause mild skin and eye irritation. Appropriate personal protective equipment including nitrile gloves and safety goggles should be worn during handling. Work should be conducted in a well-ventilated area. Avoid inhalation of dust and direct contact with skin or eyes. In case of exposure, flush affected areas with water.
Quality control involves HPLC analysis (typically showing ≥97% purity), melting point determination, and spectroscopic methods. FTIR confirms the presence of both carboxylic acid and amino groups, while ⊃1;H and ⊃1;⁹F NMR provide structural verification. Elemental analysis may be used for comprehensive characterization.
The strategic combination of two fluorine atoms with both amino and carboxyl groups creates unique electronic properties and reactivity patterns. This arrangement enhances the compound's utility in designing bioactive molecules with improved metabolic stability and membrane permeability.
This specialty chemical is commercially available through fine chemical suppliers in quantities ranging from grams to kilograms. Many suppliers provide certificates of analysis with each batch and can accommodate custom synthesis requests. Technical support is typically available for specific application questions.
