313545-72-1 2-Cholro-4-flurophenylboronic acid

313545-72-1 2-Cholro-4-flurophenylboronic acid Introduction

We are a pharmaceutical intermediate manufacturer of 2-Cholro-4-flurophenylboronic acid.

Its CAS No. is 313545-72-1

Our pharmaceutical intermediates can be used in a variety of APIs.

313545-72-1 2-Cholro-4-flurophenylboronic acid Specifications

313545-72-1 2-Cholro-4-flurophenylboronic acid Factory display

Office Environment

Laboratory

Workshop/Warehouse

313545-72-1 2-Cholro-4-flurophenylboronic acid Certification

Certificate

313545-72-1 2-Cholro-4-flurophenylboronic acid FAQ

1. Manufacturer or trading company for 313545-72-1 2-Cholro-4-flurophenylboronic acid?

2-Cholro-4-flurophenylboronic acid is produced by EASTFINE , and we are in charge of overseas selling . Not just trading compamy .

2. 313545-72-1 2-Cholro-4-flurophenylboronic acid supplier and factories or wholesale locates in such countries like?

China,America,Brazil,England,Russia,Poland,India,Pakistan,NewZealand,Korea,Australia,Dubai,Turkey,Indonesia,UAE.

3. Can I get a sample for trying 313545-72-1 2-Cholro-4-flurophenylboronic acid?

yes , you can have 1 2-Cholro-4-flurophenylboronic acid sample for starting the business , but it is not free

4. What the MOQ of 313545-72-1 2-Cholro-4-flurophenylboronic acid?

please contact sale team for detail .

5. What is 2-Chloro-4-fluorophenylboronic acid?

2-Chloro-4-fluorophenylboronic acid (CAS 313545-72-1) is an organoboron compound with the molecular formula C₆H₅BClFO₂. This white to off-white crystalline solid contains both chlorine and fluorine substituents on the aromatic ring along with a reactive boronic acid group, making it a valuable Suzuki coupling reagent in pharmaceutical and materials chemistry.

6. What are the physical properties of this compound?

The compound typically appears as a white to light beige crystalline powder with a molecular weight of 174.36 g/mol. It has a melting point range of 150-155°C (with decomposition) and demonstrates good solubility in polar organic solvents like methanol and THF, though it has limited solubility in water. The material may gradually darken upon prolonged exposure to air.

7. How should this chemical be stored properly?

For optimal stability, store in tightly sealed containers under inert atmosphere at temperatures between 2-8°C. The boronic acid group is moisture-sensitive, so containers should include desiccants and be protected from humidity. Under these conditions, the material maintains good stability for at least 24 months. Keep away from strong oxidizers.

8. What are the primary applications in organic synthesis?

This compound serves as a versatile building block for Suzuki-Miyaura cross-coupling reactions, enabling the formation of biaryl structures important in drug development. The chlorine and fluorine substituents allow for further functionalization while providing electronic tuning of the aromatic system. It's particularly valuable in synthesizing pharmaceutical intermediates for CNS drugs and kinase inhibitors.

9. What safety precautions should be observed?

While not highly toxic, the compound may cause irritation to skin, eyes, and respiratory system. Use appropriate PPE including nitrile gloves, safety goggles, and proper ventilation. Avoid inhalation of dust and direct contact. In case of exposure, flush affected areas with water. The material is stable under normal conditions but may decompose at elevated temperatures.

10. How is the purity of this material typically verified?

Quality control involves several analytical techniques including HPLC (typically showing ≥97% purity), melting point determination, and spectroscopic methods. ⊃1;H NMR confirms the aromatic proton pattern, while ⊃1;⊃1;B NMR verifies the boronic acid functionality. Elemental analysis may be used for comprehensive characterization of chlorine and fluorine content.

11. What makes this compound chemically valuable?

The combination of halogen substituents with the boronic acid group creates exceptional versatility. The chlorine allows for subsequent nucleophilic substitutions, while the fluorine enhances the electron-deficient character of the ring. The boronic acid enables efficient cross-coupling reactions under mild conditions, making it ideal for constructing complex molecular architectures.

12. Where can researchers obtain this chemical?

This specialty reagent is commercially available through fine chemical suppliers in quantities ranging from grams to kilograms. Many suppliers provide certificates of analysis with each batch and can accommodate custom synthesis requests. Technical support is typically available for specific application development and scale-up questions.