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Custom Synthetic Intermediates
403-24-7
Melting point: 170 °C
Boiling point: 352.5±27.0 °C(Predicted)
Density: 1.568±0.06 g/cm3(Predicted)
Storage temp.: Sealed in dry,Room Temperature
Product Description
We are a pharmaceutical intermediate manufacturer of 2-Fluoro-4-nitrobenzoic acid.
Its CAS No. is 403-24-7
Our pharmaceutical intermediates can be used in a variety of APIs.
| Product Category | Custom Synthetic Intermediates |
| CAS NO | 403-24-7 |
| Product Specifications | Melting point: 170 °C Boiling point: 352.5±27.0 °C(Predicted) Density: 1.568±0.06 g/cm3(Predicted) Storage temp.: Sealed in dry,Room Temperature |
Office Environment
Laboratory
Workshop/Warehouse
Certificate
2-Fluoro-4-nitrobenzoic acid is produced by EASTFINE , and we are in charge of overseas selling . Not just trading compamy .
China,America,Brazil,England,Russia,Poland,India,Pakistan,NewZealand,Korea,Australia,Dubai,Turkey,Indonesia,UAE.
yes , you can have 1 2-Fluoro-4-nitrobenzoic acid sample for starting the business , but it is not free
please contact sale team for detail .
2-Fluoro-4-nitrobenzoic acid (CAS 403-24-7) is a fluorinated aromatic compound with molecular formula C₇H₄FNO₄. This yellow crystalline solid contains both a carboxylic acid group and a nitro substituent on a fluorine-substituted benzene ring, making it a valuable intermediate in pharmaceutical and agrochemical synthesis.
The compound typically appears as a yellow crystalline powder with a molecular weight of 185.11 g/mol. It has a melting point range of 145-150°C and demonstrates moderate solubility in polar organic solvents like ethanol and DMSO, while being poorly soluble in water. The material is stable at room temperature but may gradually darken upon prolonged exposure to light.
For optimal stability, store in tightly sealed amber glass containers protected from light and moisture at room temperature. While relatively stable, storage under inert atmosphere (nitrogen or argon) is recommended for long-term preservation. Properly stored material maintains excellent stability for at least 24 months. Keep away from strong reducing agents and bases.
This multifunctional compound serves as a key building block in medicinal chemistry, particularly for developing fluorinated pharmaceutical compounds. The nitro group enables various reduction and substitution reactions, while the carboxylic acid allows for esterification or coupling reactions. It's especially useful in designing antibacterial agents and photoactive compounds.
The compound may cause skin and eye irritation. Appropriate personal protective equipment including nitrile gloves and safety goggles should be worn during handling. Work should be conducted in a well-ventilated area or fume hood. Avoid inhalation of dust and direct contact with skin or eyes. In case of exposure, flush affected areas with water immediately.
Quality control involves HPLC analysis (typically showing ≥98% purity), melting point determination, and spectroscopic characterization. FTIR confirms the presence of both carboxylic acid and nitro groups, while ⊃1;H and ⊃1;⁹F NMR provide structural verification. Elemental analysis may be performed for comprehensive quality assessment.
The strategic combination of fluorine and nitro substituents with the carboxyl group creates unique electronic properties and reactivity patterns. The electron-withdrawing nature of these groups activates the aromatic ring for nucleophilic substitution while providing multiple sites for further functionalization in drug design.
This specialty chemical is commercially available through fine chemical suppliers in quantities ranging from grams to kilograms. Many suppliers provide certificates of analysis with each batch and can accommodate custom synthesis requests. Technical support is typically available for specific application questions and process optimization.
