Building Block
3721-95-7
Clear colorless to yellow liquid
Melting point: −7.5 °C(lit.)
Boiling point: 195 °C(lit.)
Density: 1.047 g/mL at 25 °C(lit.)
Storage temp.: Sealed in dry,Room Temperature
Availability: | |
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Product Description
Product Category | Building Block |
CAS NO | 3721-95-7 |
Product Specifications | Clear colorless to yellow liquid Melting point: −7.5 °C(lit.) Boiling point: 195 °C(lit.) Density: 1.047 g/mL at 25 °C(lit.) Storage temp.: Sealed in dry,Room Temperature |
3721-95-7 CYCLOBUTANECARBOXYLIC ACID.pdf
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Cyclobutanecarboxylic acid is an organic compound with the molecular formula C5H8O2. It consists of a cyclobutane ring (a four-membered carbon ring) attached to a carboxyl group (-COOH). This compound is part of the class of cyclic carboxylic acids and exhibits the typical reactivity of both strained cyclic compounds and carboxylic acids.
6. What are the uses of 3721-95-7 Cyclobutanecarboxylic acid?
· Organic Synthesis: Cyclobutanecarboxylic acid serves as an intermediate in the synthesis of various organic compounds, including pharmaceuticals, agrochemicals, and polymers.
· Building Block for Chemical Reactions: It can undergo reactions such as esterification, decarboxylation, and ring-opening reactions due to the strain in the cyclobutane ring.
· Research: It is used in research settings to study strained ring systems and carboxylate chemistry.
7. How is 3721-95-7 Cyclobutanecarboxylic acid synthesized?
Cyclobutanecarboxylic acid can be synthesized using several methods, such as:
· Ring-closure reactions: Cyclobutane rings can be formed from precursor compounds that include a carboxyl group. One possible synthetic route involves starting with a linear carboxylic acid and employing cyclization techniques.
· Electrophilic addition reactions: The carboxyl group can be introduced onto a cyclobutane precursor using electrophilic substitution methods.
Specific synthetic pathways often depend on the desired substitution patterns and functional group compatibility.
· Appearance: It is typically a white solid or crystalline substance.
· Boiling Point: Cyclobutanecarboxylic acid has a boiling point of around 210-215°C (410-419°F).
· Solubility: It is soluble in organic solvents like ethanol, acetone, and ether, but is poorly soluble in water due to the hydrophobic nature of the cyclobutane ring and the carboxyl group.
· Esterification: Cyclobutanecarboxylic acid can react with alcohols to form esters, which are widely used in flavor, fragrance, and industrial applications.
· Decarboxylation: The carboxyl group can be removed by heating or in the presence of a decarboxylation agent to form a cyclobutane derivative.
· Ring-opening reactions: The strained cyclobutane ring can undergo ring-opening reactions, which can be useful for synthesizing other organic molecules or for studying ring strain.
· Reduction: It can be reduced to form a corresponding alcohol (cyclobutanemethanol) or other reduced products.
The cyclobutane ring in cyclobutanecarboxylic acid introduces strain into the molecule, making it more reactive than non-cyclic carboxylic acids. This strain can be relieved through various chemical reactions, such as ring-opening reactions, which is useful in organic synthesis. The strain also impacts the compound's reactivity and the types of reactions it can undergo.
While cyclobutanecarboxylic acid is not highly toxic in small quantities, like many organic acids, it can cause irritation to the skin, eyes, and respiratory tract if proper safety precautions are not followed. Handling should be done with care, and appropriate personal protective equipment (PPE) such as gloves and goggles should be worn.
Yes, cyclobutanecarboxylic acid can serve as an intermediate in the synthesis of pharmaceutical compounds. The strained cyclobutane ring and the carboxyl group make it a useful building block for the development of bioactive molecules in medicinal chemistry.
The carboxyl group (-COOH) imparts typical carboxylic acid reactivity to the compound, enabling it to undergo reactions like esterification, reduction, and decarboxylation. Additionally, the presence of the carboxyl group can influence the compound’s solubility and acidity, making it a useful functional group in organic synthesis.