Building Block
951-82-6
White to cream Crystalline Powder
Melting point: 117-120 °C (lit.)
Boiling point: 327.83°C (rough estimate)
Density: 1.2668 (rough estimate)
Storage temp.: Sealed in dry,Room Temperature
Availability: | |
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Product Description
Product Category | Building Block |
CAS NO | 951-82-6 |
Product Specifications | White to cream Crystalline Powder Melting point: 117-120 °C (lit.) Boiling point: 327.83°C (rough estimate) Density: 1.2668 (rough estimate) Storage temp.: Sealed in dry,Room Temperature |
951-82-6 3,4,5-TRIMETHOXYPHENYLACETIC ACID.pdf
3,4,5-Trimethoxyphenylacetic acid is produced by EASTFINE , and we are in charge of overseas selling . Not just trading company .
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3,4,5-Trimethoxyphenylacetic acid is an organic compound consisting of a phenylacetic acid structure, with three methoxy groups (-OCH3) attached to the 3, 4, and 5 positions on the phenyl ring. Its molecular formula is C10H12O5.
· Organic synthesis: It can be used as an intermediate in the synthesis of more complex molecules, particularly in the production of pharmaceuticals and agrochemicals.
· Medicinal chemistry: The compound is of interest for research due to its structure, which may provide bioactivity through its interaction with specific biological targets.
· Natural product synthesis: The compound is related to several natural products and may serve as a precursor or building block for bioactive compounds.
The structure consists of a phenylacetic acid backbone (a benzene ring attached to an acetic acid group) with three methoxy groups (-OCH3) attached at the 3, 4, and 5 positions of the aromatic ring. These methoxy groups contribute electron-donating properties, which can influence the molecule's reactivity.
3,4,5-Trimethoxyphenylacetic acid can be synthesized through several methods, typically involving the following steps:
· Electrophilic aromatic substitution: Methoxy groups are introduced onto a phenylacetic acid core by reacting the starting material with methylating reagents (such as methyl iodide) in the presence of a catalyst (like potassium carbonate or sodium hydroxide).
· Selective methylation: Precise control of reaction conditions ensures that the methoxy groups are installed at the 3, 4, and 5 positions on the phenyl ring.
· Appearance: The compound typically appears as a white solid.
· Solubility: It is moderately soluble in organic solvents like ethanol or acetone but may have low solubility in water due to the presence of the methoxy groups and the carboxylic acid group.
The methoxy groups (-OCH3) at the 3, 4, and 5 positions of the phenyl ring are electron-donating groups. This affects the compound's chemical reactivity, particularly in electrophilic substitution reactions. The methoxy groups also contribute to the compound's stability and could influence its interaction with biological targets in medicinal chemistry.
While 3,4,5-trimethoxyphenylacetic acid itself may not be a widely used pharmaceutical agent, it is an important intermediate in the synthesis of bioactive molecules. The presence of methoxy groups and the phenylacetic acid core structure make it a useful precursor in designing molecules with potential pharmacological activity.
· Toxicity: There is limited specific information on the toxicity of 3,4,5-trimethoxyphenylacetic acid, but it should be handled with care in a laboratory setting. As a general rule, chemicals with carboxylic acid groups should be handled with caution, as they can be irritating to the skin, eyes, and mucous membranes.
· Safety precautions: Use personal protective equipment (PPE) such as gloves, goggles, and lab coats, and work in a well-ventilated area or fume hood.
Yes, 3,4,5-Trimethoxyphenylacetic acid can undergo various chemical reactions, such as:
· Esterification: Reaction with alcohols can form esters, which are commonly used in organic synthesis.
· Reduction: The carboxylic acid group could be reduced to an aldehyde or alcohol.
· Nucleophilic substitution: The methoxy groups might be involved in reactions with electrophiles or other reactive species.
The methoxy groups are electron-donating through resonance and inductive effects, which generally make the aromatic ring more reactive towards electrophilic substitution reactions. This can influence the molecule’s reactivity in various organic reactions.