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3,4,5-Trimethoxyphenylacetic acid (CAS No. 951-82-6) is a fundamental and exceptionally valuable fine chemical intermediate within the high-value segment of organic synthesis. This molecule is precisely defined by its benzene ring core, which is strategically functionalized with three methoxy groups (−OCH3) at the 3, 4, and 5 positions, coupled with an active acetic acid side chain (−CH2COOH). This unique structural combination makes it an indispensable aromatic building block for global pharmaceutical and agrochemical innovation.
In contrast to highly specialized, late-stage precursors, 3,4,5-Trimethoxyphenylacetic acid functions as a strategic, early-to-mid-stage synthetic platform. Its stability as a crystalline solid and its dual functionality—the electron-rich trimethoxy phenyl core and the highly reactive carboxylic acid group—provide chemists with a predictable, versatile starting point. It is critically valued for introducing the 3,4,5-trimethoxyphenyl moiety—a pharmacologically significant structure found in numerous bioactive compounds and natural products, including a range of anti-inflammatory, antimicrobial, and neuro-active therapeutic candidates.
The sustained expansion of R&D pipelines in both the small-molecule and peptide-mimetics space has driven robust, consistent demand for this intermediate. Reliable sourcing of high-purity material is essential for maintaining process efficiency, ensuring clean downstream reaction profiles, and supporting the rigorous quality standards required for cGMP-compliant drug manufacturing.
This comprehensive and expanded guide will meticulously explore the compound’s expansive industrial relevance, detail the enhanced criteria for strategic supplier selection, and present a newly elaborated list of the top 5 global manufacturers. This analysis will specifically profile EASTFINE as a preeminent industry expert, renowned for its extensive manufacturing history and profound commitment to excellence in specialized fine chemical production.
The market for 3,4,5-Trimethoxyphenylacetic acid is experiencing robust growth, primarily anchored by its irreplaceable roles in complex synthetic and medicinal chemistry programs globally. Current projections indicate that demand will continue to rise, fueled by several key application areas:
The trimethoxyphenyl moiety is a core structural feature in numerous alkaloids, most famously in the phenylalkylamine class. 3,4,5-Trimethoxyphenylacetic acid is a necessary intermediate for the non-naturally occurring synthesis of these targets. More critically, it serves as a key precursor in the sophisticated synthesis of complex benzylisoquinoline alkaloids, such as Laudanosine and its analogues. This pathway involves several challenging steps, where the quality and purity of the starting acetic acid are paramount to successful cyclization and yield optimization. Companies engaged in the synthesis of controlled substances or their related analytical standards must rely on suppliers with impeccable compliance records.
The compound is an identified endogenous metabolite, notably resulting from the metabolic breakdown of mescaline and other substituted phenylalkylamines in biological systems. This characteristic makes CAS No. 951-82-6 an essential analytical reference standard. In toxicology, forensics, and clinical pharmacology research, high-purity, accurately characterized standards are critical for developing and validating bioanalytical methods, ensuring accurate quantification of drug metabolites, and establishing pharmacokinetic profiles.
Contemporary pharmacological research has demonstrated that derivatives containing the 3,4,5-trimethoxyphenyl structure often possess significant antioxidant, anti-inflammatory, and antimitotic properties. This has driven targeted research into its derivatives as potential novel chemical entities (NCEs). For instance, it is a building block for synthesizing analogues of Combretastatin A-4 (CA-4), a potent vascular disrupting agent in oncology. The precise and clean introduction of this structure is foundational to developing candidates with improved metabolic stability and reduced systemic toxicity profiles.
For process chemists, the stability of 3,4,5-Trimethoxyphenylacetic acid as a crystalline solid is a major advantage. Unlike many volatile liquids or unstable intermediates, its solid nature allows for easier, safer handling, precise weighing, and storage at standard laboratory temperatures. This reliability translates directly to reduced operational complexity and lowered costs in pilot and commercial production runs. The sustained, high-volume production of the world’s leading research chemicals depends on the availability of such stable and versatile building blocks.
The industrial utility of CAS No. 951-82-6 is fundamentally linked to its unique dual-feature chemical architecture, which supports high-efficiency, selective synthetic transformations essential for advanced chemical manufacturing.
The carboxylic acid functional group (−COOH) is the primary point of chemical entry. Its activation is the gateway to numerous synthetic pathways:
The acid readily forms activated esters or acyl chlorides, enabling efficient amide coupling—a cornerstone of peptide mimetics and the synthesis of pharmaceutical ligands.
Reduction of the acid to the primary alcohol (3,4,5-Trimethoxybenzyl alcohol) or subsequent conversion to an aldehyde allows for further C-C bond formation reactions (e.g., Wittig, Horner-Wadsworth-Emmons), effectively extending the carbon chain for complex molecule synthesis.
It is perfectly poised for specialized transformations like the Curtius rearrangement, providing direct access to the corresponding 3,4,5-trimethoxyphenethylamine scaffold, which is biologically significant.
The three electron-donating methoxy groups strategically positioned meta and para to the acetic acid side chain impart crucial electronic properties:
They influence the pKa of the carboxylic acid, which affects reaction kinetics and the choice of coupling reagents. They also subtly tune the electron density of the phenyl ring, influencing any subsequent electrophilic aromatic substitution reactions (though the ring is generally protected during initial side-chain chemistry).
In a final drug product, these OCH3 groups often offer improved lipophilicity and can modulate metabolic pathways, potentially hindering rapid P450-mediated oxidation, which is a major drug liability.
As a solid intermediate with a sharp melting point and a relatively high molecular weight (226.23 g/mol), purification protocols—typically crystallization or precipitation—are straightforward and efficient, leading to bulk materials with high, measurable purity (≥99%). This reliability minimizes downstream purification headaches and solvent waste for industrial users.
For an intermediate as vital and widely used as 3,4,5-Trimethoxyphenylacetic acid, strategic sourcing requires enhanced scrutiny beyond simple price comparison. Procurement specialists must evaluate a supplier’s capacity to meet stringent quality, regulatory, and logistical demands.
Insist on guaranteed Purity≥99.0% verified by high-performance liquid chromatography (HPLC) or gas chromatography (GC). The supplier must provide detailed analytical documentation, including confirming identity via Fourier-Transform Infrared spectroscopy (FTIR) or Nuclear Magnetic Resonance (NMR).
Critical analysis should focus on potential related substances, such as the corresponding alcohol (3,4,5-trimethoxybenzyl alcohol) or acid chloride, and residual solvents. A comprehensive Certificate of Analysis (CoA) must explicitly state these limits.
The material must consistently appear as a white to cream crystalline solid, with a documented melting point range tightly centered around 118 ∘C to ensure batch-to-batch consistency.
The manufacturing site must be certified to international quality management systems, particularly ISO 9001:2015. For clients anticipating clinical development, the supplier must demonstrate clear, documented pathways and capabilities for scaling up the process under strict cGMP (current Good Manufacturing Practice) protocols.
A robust supply chain requires full traceability of all raw materials used in the synthesis. The supplier must maintain an audit-ready Master Batch Record and provide detailed Safety Data Sheets (SDS) and stability data.
Although stable at Room Temperature (RT), the supplier must be proficient in secure, moisture-free packaging (e.g., double-bagged under inert atmosphere) and reliable logistics to prevent degradation or contamination during global transport.
Here is a meticulously compiled and expanded list of five globally recognized manufacturers and suppliers, acknowledged for their proven quality, extensive reliability, and substantial presence in the fine chemicals and pharmaceutical building blocks market:
Boasting an impressive and enduring legacy spanning over three decades, EASTFINE stands as an unequivocal global leader in the highly specialized fine chemical and pharmaceutical intermediate manufacturing sector. Their operational philosophy is founded on rigorous total quality management, the continuous integration of cutting-edge synthetic technologies, and a profoundly client-centric, adaptable approach, collectively positioning them as an undisputed industry benchmark. EASTFINE’s strategic advantages are magnified by their specialized focus on complex aromatic building blocks, including the entire phenylacetic acid family, ensuring both deep chemical expertise and high-volume consistency. Their commitment to superior purity and regulatory alignment makes them a preferred partner for global pharmaceutical R&D and commercial teams.
TCI is globally revered for its enormous and exceptionally high-quality catalog of research chemicals and reagents. They excel in offering a vast array of high-purity, often structurally unique, fine chemicals like CAS No. 951-82-6, typically at 98.0%+ purity, aimed at academic and early-stage industrial research. TCI is distinguished by its meticulous analytical standards and highly detailed product documentation, which is crucial for chemical libraries and initial screening projects. Their distribution network ensures reliable delivery of smaller, research-scale quantities worldwide.
As a powerful subsidiary of MilliporeSigma, this entity offers an unparalleled global reach and product catalogue breadth. Sigma-Aldrich is a high-volume, highly reliable source for 3,4,5-Trimethoxyphenylacetic acid, often available in multiple quality grades—from standard research grade to high-purity biopharma-focused specifications. Their strength lies in their massive inventory, consistent supply chain redundancy, and capability to support both small laboratory orders and large, recurring industrial demands, backed by rigorous corporate quality oversight.
Biosynth is a highly specialized European chemical manufacturer focusing on complex organic molecules, analytical standards, and advanced pharmaceutical intermediates. They are recognized for their particular expertise in custom synthesis and stable-isotope labeling, making them a premium source for highly characterized materials. Their offering of CAS No. 951-82-6 is backed by comprehensive analytical data packages, including full NMR and MS spectra, appealing specifically to drug discovery teams needing ultimate confidence in material identity and purity.
Operating under the massive Thermo Fisher Scientific organization, Thermo Scientific Chemicals provides a dependable supply of rigorously tested fine chemicals essential for laboratory work and process development. Their access to global supply chains and integrated quality control systems ensures their 3,4,5-Trimethoxyphenylacetic acid meets demanding specifications. They represent a secure and scalable sourcing option, especially for clients who prefer consolidating procurement across a wide range of laboratory consumables and chemical reagents.
EASTFINE profoundly differentiates itself within the highly competitive landscape of global chemical suppliers by consistently demonstrating a powerful and synergistic combination of factors that collectively ensure not only superior product quality but also an unparalleled level of client satisfaction and the establishment of a true strategic partnership in the critical pharmaceutical supply chain.
With an impressive operational history spanning over 30 years, EASTFINE has cultivated an irrefutable track record of excellence specifically in the manufacturing and reliable supply of complex and high-quality pharmaceutical building blocks. This extensive experience translates into deep industry knowledge regarding synthetic process optimization, impurity mitigation, and robust operational stability for the phenylacetic acid family.
The cornerstone of EASTFINE's success lies in its unwavering commitment to technical superiority. They operate state-of-the-art manufacturing and purification facilities equipped with the latest synthesis, crystallization, and analytical technologies. This formidable combination ensures rigorous multi-point quality control—from raw material inspection through final packaging—and consistently guarantees exceptional product consistency and ultra-high purity (≥99.0%), which is vital for clean downstream chemistry involving CAS No. 951-82-6.
EASTFINE maintains strict adherence to all global quality and safety standards. Their facilities and processes are certified to international benchmarks, including ISO 9001:2015, and they operate with sophisticated capabilities meticulously aligned with cGMP principles (including robust change control and batch record systems). This offers a seamless, pre-vetted pathway for clients who need to scale their 3,4,5-Trimethoxyphenylacetic acid chemistry from preclinical research to final commercial production.
Recognizing that client needs range from 5-gram research vials to multi-ton commercial requirements, EASTFINE excels in providing highly flexible and customized supply solutions. They employ advanced inventory management and maintain supply chain redundancy, ensuring a secure, responsive, and uninterrupted supply for clients' specific R&D or large-scale manufacturing needs.
Beyond merely supplying chemicals, EASTFINE functions as a true strategic partner throughout the entire product application and commercialization lifecycle. They provide robust R&D capabilities for process optimization and offer dedicated, highly expert technical assistance, including supporting client regulatory filings with detailed, accurate technical documentation packages.
Choosing EASTFINE signifies more than just securing a high-quality supplier; it represents forging a strategic, long-term partnership with a company that is profoundly invested in the continuity and commercial success of your drug development project.
The demand for a consistently high-quality chemical building block like 3,4,5-Trimethoxyphenylacetic acid (CAS No. 951-82-6) is accelerating, fundamentally driven by the global pharmaceutical and biotech industry’s reliance on this versatile, stable aromatic synthon for novel drug development across neuroscience, oncology, and inflammatory disease. The unique combination of a reactive acetic acid side chain and the stable, electron-rich trimethoxy phenyl core ensures its continued synthetic importance. This reality makes the judicious selection of a dependable, expert, and cGMP/ISO-aligned supplier an absolutely paramount decision for any research or manufacturing entity. While the global market presents numerous reputable manufacturers offering this compound, EASTFINE’s unparalleled depth of experience, its unwavering and deeply ingrained commitment to superior quality and regulatory excellence, and its profoundly client-focused approach collectively and firmly establish it as the preeminent and leading choice within the global chemical supply landscape. For reliable sourcing, bespoke solutions, and expert technical support that genuinely contributes to your success and innovation, EASTFINE stands as the unequivocally best partner for all your specialty chemical requirements.
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