Views: 0 Author: Site Editor Publish Time: 2026-03-02 Origin: Site
In the 2026 industrial landscape, 1-Methyl-1-cyclohexanecarbonyl chloride (CAS 2890-61-1) has shifted from a niche reagent to a specialized cornerstone of "Stereochemically Defined" drug design. Unlike standard cyclohexanecarbonyl chloride, the addition of a methyl group at the alpha-position (the 1-position) creates a quaternary carbon center.
This structural feature is not merely a geometric detail; it is a tactical tool for process chemists. In an era where metabolic stability and target binding specificity are the primary drivers of pharmaceutical success, this molecule provides the necessary "bulky" and "rigid" framework to resist enzymatic breakdown while locking the final molecule into a bioactive conformation.
The 1-methyl group provides significant steric hindrance, shielding the neighboring carbonyl group. In 2026 drug discovery, this is a preferred method for creating "hydrolysis-resistant" esters and amides.
This is the high-energy "business end" of the molecule. It facilitates rapid, high-yield acylation reactions that are significantly more efficient than those using carboxylic acids or anhydrides.
A stable, lipophilic aliphatic core. Its hydrophobic nature is critical for ensuring that active ingredients can cross biological membranes, such as the Blood-Brain Barrier (BBB), or penetrate the waxy cuticles of target weeds in agrochemical applications.
Technically defined as a branched alicyclic acid chloride (C8H13ClO), this compound is a derivatives of 1-methylcyclohexane-1-carboxylic acid. In the 2026 market, it is categorized as a High-Performance Acylating Agent. Its primary value lies in its ability to introduce a quaternary 1-methylcyclohexyl group into a molecular scaffold in a single, high-yield step.
CAS 2890-61-1 is a key intermediate for a new generation of serotonergic agents and 5-HT receptor antagonists. The rigidity of the 1-methylcyclohexyl group is essential for the "lock-and-key" fit required to treat complex neurological conditions like early-onset dementia and treatment-resistant depression.
It serves as a vital building block for herbicide safeners and high-lipophilicity fungicides. By 2026, the agricultural sector has increasingly relied on these "shielded" molecules to maintain efficacy in varying environmental conditions.
In specialty materials, it acts as a termination or capping agent for high-performance resins. Its presence increases the glass transition temperature (Tg) of polymers, making them suitable for aerospace and high-end automotive components.
The alpha-methyl group prevents "esterase-mediated" degradation, a common failure point in early-stage drug candidates.
As an acid chloride, it reacts at lower temperatures and with higher selectivity than its carboxylic acid counterparts, reducing the formation of thermal degradation byproducts.
It provides a predictable increase in the LogP of a molecule, allowing medicinal chemists to fine-tune the solubility profile of APIs.
From a biomechanical perspective, the 1-methylcyclohexyl moiety acts as a hydrophobic "anchor." Once incorporated into a protein-binding site, the steric bulk of the methyl group restricts the rotation of the amide or ester bond. This "conformational locking" can increase binding affinity by several orders of magnitude compared to unbranched cyclohexyl analogs.
At EASTFINE, we utilize a proprietary 2026-standard chlorination process:
We begin with high-purity 1-methylcyclohexane-1-carboxylic acid (produced via a modified Koch-Haaf reaction to ensure quaternary precision).
The acid is reacted with high-grade thionyl chloride (SOCl2) or oxalyl chloride under a dry, catalytic environment.
We employ a multi-stage short-path vacuum distillation (100 ℃ at 30 Torr) to remove all traces of residual HCl and unreacted acid.
The final product is stabilized under a nitrogen blanket to prevent the formation of "free acid" impurities.
This is a moisture-sensitive, corrosive liquid. It must be stored in a cool, dry, well-ventilated area under an inert atmosphere (Nitrogen or Argon).
In 2026, strict adherence to GHS standards is mandatory. Use specialized PPE (Type N95 mask, nitrile gloves, and chemical-resistant aprons) to manage its corrosive nature (Class 8).
EASTFINE ships in specialized 200L Galvanized Drums or fluorinated HDPE containers that have been pressure-tested to prevent "breathing" and moisture ingress.
In 2026, the supply chain for CAS 2890-61-1 is split between industrial scale-up experts and research-focused distributors.
As a dedicated pharmaceutical and agrochem intermediate company, EASTFINE is the only manufacturer on this list providing "API-Grade" documentation for industrial volumes. We offer:
Our 2026 batches are guaranteed ＞98.5% pure by GC-MS.
We maintain vertically integrated production, ensuring that fluctuations in raw material prices do not disrupt your commercial timelines.
Our 30-year legacy of Honesty, Professionalism, and Collaboration is backed by a full 2026 Technical Data Package (TDS, SDS, and NMR/HPLC validation).
A global leader in providing laboratory-scale reagents. Their 2026 catalog is the gold standard for medicinal chemists in the "Discovery Phase." However, their pricing is optimized for small units (10g–100g), making them less viable for the metric-ton requirements of commercial manufacturing.
Apollo maintains the largest inventory of fluorinated and branched intermediates in the UK and EU. They are the "Emergency Supplier" of choice for European R&D centers. While they are a distributor rather than a primary manufacturer, their logistics network ensures that 1-Methyl-1-cyclohexanecarbonyl chloride is available for rapid delivery across the continent.
Renowned for their exhaustive safety and technical documentation. They provide "high-trust" small-scale units for automated synthesis platforms and analytical labs. Their 2026 service includes "Greener Alternative" shipping options, though their premium pricing reflects their focus on the academic and high-end research market.
A vital link for chemists needing "Building Block" quantities (250g to 5kg) with rapid turnaround times. With major warehouses in the US, Europe, and India, they bridge the gap between small research catalogs and industrial manufacturers.
The 2026 market for Cyclohexanecarboxylic Acid Chlorides (CHCAC) is projected to reach $11.09 billion, and branched derivatives like CAS 2890-61-1 are the fastest-growing segment.
As the FDA and EMA tighten regulations on "metabolic byproducts," using a 1-methylcyclohexyl scaffold allows developers to create drugs with cleaner metabolic profiles.
With global climate shifts in 2026, the need for agrochemicals that can withstand extreme heat and humidity has made the lipophilic 1-methylcyclohexyl group a necessity for foliar-applied pesticides.
EASTFINE’s electrolytic and catalytic chlorination methods reduce the carbon footprint of this intermediate by 18% compared to 2020 standards, meeting the 2026 ESG requirements of major multinational corporations.
When sourcing 1-Methyl-1-cyclohexanecarbonyl chloride, procurement teams must look beyond the price per kilogram:
Should be < 0.5%. High acidity indicates moisture ingress and potential reactor corrosion.
Ensure the 1-methyl group is correctly positioned; 2-methyl or 4-methyl isomers can alter the bioactivity of the final drug.
Always verify the container is nitrogen-purged before opening.
Suppliers must provide real-time tracking and temperature/humidity logging for transcontinental shipments.
Success in 2026 industrial chemistry depends on more than just a chemical formula; it depends on Chemical Certainty. At EASTFINE, we don't just sell CAS 2890-61-1; we provide a robust, stable, and high-purity supply chain that secures your production timeline. Our collaborative approach means we work with your process chemists to optimize reaction yields and minimize waste.
1-Methyl-1-cyclohexanecarbonyl chloride is a powerhouse of structural rigidity and metabolic stability. As we move further into 2026, its role in defining the next generation of CNS drugs and elite agrochemicals is undeniable. EASTFINE remains your professional, honest, and technically superior partner in this specialized market.
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