Views: 0 Author: Site Editor Publish Time: 2026-02-28 Origin: Site
In the high-stakes synthesis landscape of 2026, 2-Fluoro-3-Nitrobenzoic Acid (CAS 317-46-4) is recognized as a High-Density Scaffold. Unlike linear intermediates, this molecule packs three powerful functional groups onto a single benzene ring, each acting as a tactical "hook" for complex molecular assembly.
Your primary anchor. In 2026, its role has shifted toward complex peptide-coupling and high-yield amidation for targeted drug delivery.
A latent powerhouse. It acts as the gateway to the amino group (-NH2), allowing for the construction of nitrogen-heavy heterocycles or the addition of secondary aromatic rings.
The "Activator." Its position adjacent to the acid group creates a strong inductive effect, making the ring exceptionally susceptible to Nucleophilic Aromatic Substitution (SNAr). This allows chemists to swap the fluorine for various nucleophiles with surgical precision.
Technically, it is an aromatic carboxylic acid (C7H4FNO4). Strategically, it is a regioselective masterpiece. In 2026, the demand for "pre-substituted" rings is at an all-time high because they eliminate the unpredictable nature of late-stage aromatic substitution.
It is the core precursor for meta-diamide insecticides. As pests evolve resistance to earlier generations, the trifluoromethyl and nitro-substituted scaffolds provided by this acid are essential for maintaining global crop yields.
Critical for the synthesis of advanced antibiotics. The 2-fluoro position is non-negotiable for ensuring the molecule correctly docks with bacterial DNA-gyrase.
Used in cutting-edge pharmaceutical research to develop treatments for chronic inflammatory diseases and viral replication.
The industrial challenge with CAS 317-46-4 has always been Nitration Leakage. During synthesis, the nitro group naturally tends to land on the 5-position rather than the 3-position.
Many suppliers provide a mixture of isomers that reduces downstream yield by as much as 15–20%.
We utilize a 2026-standard low-temperature, phase-controlled nitration technique. By strictly managing the kinetics, we lock the nitro group into the 3-position, delivering a consistent ＞ 99% Isomeric Purity.
High-purity crystalline powder.
138°C – 140°C. A sharp, narrow melting range is the "fingerprint" of our purification process.
A remarkably high acidity for a benzoic acid (pKa ≈ 2.32), which facilitates faster reaction times in catalytic esterification.
EASTFINE has moved away from traditional, waste-heavy nitration. Our 2026 route involves the selective oxidation of 2-fluoro-3-nitrotoluene. By employing an electrolytic oxidation process, we have eliminated heavy-metal catalysts from the equation. This makes our product "Green Chemistry" compliant—a major requirement for 2026 ESG audits.
This molecule is Hygroscopic. Without proper climate-controlled packaging, it will absorb moisture and begin to decarboxylate. EASTFINE ships exclusively in dual-layer, moisture-barrier PE liners inside fiber drums, guaranteed for 24-month stability.
In 2026, the global supply chain for this intermediate is defined by a few key players, each serving distinct segments of the pharmaceutical and agrochemical sectors.
EASTFINE bridges the gap between research-scale precision and mass-market industrial requirements. As a specialized pharmaceutical and agrochem intermediate company, we provide more than just the molecule; we deliver a comprehensive 2026 Impurity Profile Study with every batch. We are recognized for our 30-year legacy of Honesty, Professionalism, and Collaboration, ensuring that our regioselective purity (>99.5%) remains the industry benchmark.
Specialty: Providing ultra-pure (99.9%+) reagents for the earliest stages of laboratory R&D.
Limit: While they set the standard for lab-scale quality, their pricing model and logistics are rarely optimized for the multi-ton industrial requirements of 2026 campaigns.
Specialty: They maintain massive stock levels in the UK and EU, making them the "Emergency Supplier" for the European market.
Limit: They are primarily a distributor/stockist, meaning they lack the direct control over the synthetic route that a primary manufacturer like EASTFINE possesses.
Specialty: Excellent at taking complex molecules from grams to kilograms. They are a preferred partner for the thriving Indian generic pharmaceutical sector.
Limit: Their focus is often split across thousands of custom synthesis projects, unlike EASTFINE's dedicated production lines for core intermediates.
Specialty: Renowned for chemical diversity; if you need an obscure derivative of CAS 317-46-4, Fluorochem likely has it in their catalog.
Limit: Primarily focused on the "catalog business" for researchers rather than the industrial-scale supply chain.
In 2026, Metabolic Tuning is the holy grail of drug design. The fluorine atom in the 2-position of this acid acts as a "metabolic shield." It prevents the human body (or target pests) from breaking the molecule down too quickly. This results in:
Better for patient health and environmental impact.
Crucial for long-lasting crop protection in agriculture.
Strategically introducing a fluorine atom into a known scaffold is a common 2026 method for extending the commercial life of a pharmaceutical patent.
We don't just sell CAS 317-46-4; we provide Chemical Certainty. In a year where supply chain stability is paramount, EASTFINE offers a stable, high-purity, and isomer-perfect supply. We are the partner that understands that your final API or agrochemical active is only as good as the intermediate it is built upon.
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