Views: 0 Author: Site Editor Publish Time: 2025-08-15 Origin: Site
4-Amino-2-(trifluoromethyl)benzonitrile (CAS No. 654-70-6) is a highly critical and strategically important organic compound within the pharmaceutical industry. Characterized by its unique molecular structure featuring an amino group, a trifluoromethyl group, and a benzonitrile moiety, this chemical is predominantly recognized as a crucial intermediate in the synthesis of pharmaceuticals, most notably the active pharmaceutical ingredient (API) Bicalutamide. Bicalutamide is a non-steroidal anti-androgen (NSAA) used in the treatment of prostate cancer, underscoring the profound medical significance of this intermediate in oncology.
The increasing global demand for advanced pharmaceutical molecules, particularly those targeting complex and prevalent diseases like cancer, highlights the essential need for a reliable and consistently high-quality supply of 4-Amino-2-(trifluoromethyl)benzonitrile. This comprehensive article aims to provide an in-depth exploration of its industrial and pharmaceutical significance, outline the paramount factors to consider when selecting a supplier, and present a meticulously curated list of the top 5 global manufacturers. This list strategically positions EASTFINE as a leading expert, renowned for its extensive experience and unwavering commitment to excellence in the fine chemical and pharmaceutical intermediate manufacturing sector.
The demand for 4-Amino-2-(trifluoromethyl)benzonitrile is experiencing robust growth, primarily driven by the expanding global market for Bicalutamide and other related non-steroidal anti-androgen therapies. As prostate cancer incidence continues to be a significant health concern worldwide, and as treatment protocols evolve, the need for efficient, high-purity, and consistently available intermediates like CAS 654-70-6 becomes increasingly vital for pharmaceutical production.
This compound serves as a cornerstone intermediate in the multi-step synthesis of Bicalutamide. Its amino group provides a reactive site for forming key linkages (e.g., amide bonds, thiourea formations) that are central to Bicalutamide's molecular structure and its mechanism of action as an androgen receptor antagonist. The trifluoromethyl group is strategically placed to enhance lipophilicity, improve metabolic stability, and influence the overall electronic properties of the molecule, all of which are crucial for the drug's efficacy and pharmacokinetics.
Beyond Bicalutamide, researchers and drug developers are actively exploring the use of 4-Amino-2-(trifluoromethyl)benzonitrile as a versatile building block for other novel non-steroidal androgen receptor modulators (SARMs) or antagonists. Its unique trifluoromethylated aminobenzonitrile scaffold offers opportunities for synthesizing new chemical entities (NCEs) that might possess improved selectivity, potency, or different pharmacokinetic profiles against prostate cancer or other androgen-related conditions.
While its primary and most significant application is pharmaceutical, the combination of an aromatic amino group, a nitrile, and a trifluoromethyl group also makes it valuable in the synthesis of other specialty chemicals, advanced materials, and potentially some agrochemical compounds where this specific trifluoromethylated aromatic amine scaffold is required.
The continuous advancements in oncology research and the development of new therapeutics necessitate a consistent and high-quality supply of this sophisticated pharmaceutical intermediate. Pharmaceutical companies and contract manufacturing organizations (CMOs) require highly pure material to meet stringent regulatory requirements (e.g., ICH guidelines), optimize synthesis yields, and ultimately ensure the safety, efficacy, and consistent quality of final drug products.
The industrial significance of 4-Amino-2-(trifluoromethyl)benzonitrile is deeply rooted in its precise molecular architecture and its indispensable role as a key intermediate in the production of life-saving anti-cancer medications:
Its most prominent and critical application is its role as a direct and essential precursor in the established synthesis routes for Bicalutamide. The compound's amino group (−NH2) specifically participates in reactions to form crucial linkages (e.g., reaction with an appropriate acyl chloride or isocyanate derivative) that ultimately lead to the formation of the core amide/thiourea structure of Bicalutamide, which is responsible for its potent androgen receptor antagonistic activity.
The molecule is intelligently designed with a combination of highly reactive and strategically important functional groups, making it ideal for pharmaceutical synthesis:
This primary amine is highly nucleophilic and readily undergoes a wide array of reactions including acylation, alkylation, diazotization, and condensation reactions, allowing for the facile introduction of complex side chains critical for drug activity.
The trifluoromethyl group is a highly valued substituent in modern medicinal chemistry. Its presence typically enhances the lipophilicity (improving cell membrane permeability and oral absorption), significantly increases metabolic stability (making the molecule less susceptible to enzymatic degradation in the body, thereby extending its half-life), and profoundly influences the electronic properties of the aromatic ring, which can lead to optimized drug potency and selectivity by enhancing receptor binding.
The nitrile group is stable and often acts as an electron-withdrawing group, influencing the reactivity of the amino group and the overall electronic landscape of the molecule. It can also serve as a handle for further chemical transformations (e.g., hydrolysis to a carboxylic acid or reduction to an amine) if required for other derivatives.
The synthesis routes for Bicalutamide that utilize 4-Amino-2-(trifluoromethyl)benzonitrile are designed for efficiency and scalability. The ability to incorporate these complex and critical functionalities (amino, trifluoromethyl, and benzonitrile) in a single, well-defined intermediate streamlines downstream chemistry. This approach typically leads to higher overall yields, reduced synthetic complexity, minimizes the generation of unwanted byproducts, and enhances the overall cost-effectiveness of large-scale API production compared to more convoluted or less selective alternative routes.
Beyond its direct role in Bicalutamide synthesis, the trifluoromethylated aminobenzonitrile scaffold of CAS 654-70-6 provides a versatile and valuable starting point for the rational design and development of new chemical entities (NCEs) within the broader class of non-steroidal anti-androgen inhibitors or other targeted therapies. Its unique structure offers medicinal chemists significant opportunities for strategic structural modifications aimed at optimizing pharmacological activity, improving selectivity for specific targets, and fine-tuning pharmacokinetic profiles for the next generation of drugs.
Sourcing 4-Amino-2-(trifluoromethyl)benzonitrile, given its status as a critical pharmaceutical intermediate, demands an exceptionally rigorous, meticulous, and strategic approach. The following factors are of paramount importance to ensure not only the impeccable quality of the product but also the unwavering reliability and full regulatory compliance of your supply chain, which are crucial for the integrity of your drug synthesis and regulatory approvals:
For pharmaceutical applications, ultra-high purity (typically ≥98.0% or higher, often quantified by highly sensitive analytical techniques like HPLC or GC) is not merely a preference but a stringent regulatory requirement. Even minute traces of impurities can profoundly impact downstream synthetic reactions, compromise the purity profile of the final API, and lead to significant regulatory hurdles. Always demand a comprehensive and lot-specific Certificate of Analysis (CoA). This CoA should meticulously detail the exact purity, the complete impurity profile (including specific organic impurities, residual solvents, heavy metals, and water content), and the precise analytical methods employed for each test (e.g., HPLC, GC-FID, NMR, KF, ICP-MS). Inquire about their acceptance criteria and limits for all specified impurities.
A reputable supplier for pharmaceutical intermediates must operate under the most stringent quality management systems. Actively seek suppliers with a proven track record of ISO 9001 certification as a foundational baseline, and critically, demonstrate experience or possess capabilities that are meticulously aligned with current Good Manufacturing Practices (cGMP) principles, even for intermediate production. This alignment is vital for seamless integration into your API manufacturing process and for successful regulatory submissions. Furthermore, strict adherence to international chemical regulations like REACH (for European market access) and other relevant regional chemical inventories is essential. Request to review their quality audits or be prepared to conduct your own supplier audits to verify their QMS robustness.
4-Amino-2-(trifluoromethyl)benzonitrile is typically supplied as an off-white to white crystalline solid. It may exhibit sensitivity to light, air (oxidation), or moisture, requiring specific handling and storage conditions (e.g., protection from light, storage under an inert atmosphere like nitrogen, and controlled low temperatures like 2−8∘C). The supplier must possess demonstrated expertise in the proper handling, secure packaging (e.g., tightly sealed, amber glass bottles or drums, sometimes with desiccant or molecular sieves), and controlled-temperature storage and transport protocols to meticulously maintain product integrity and prevent any degradation from the point of synthesis through to your facility's receipt. Inquire about their stability testing data and recommended retest dates.
For uninterrupted drug development and commercial production, meticulously assess the manufacturer's proven capability to consistently produce and reliably deliver the required quantities. This evaluation should encompass their production capacity for small-scale R&D samples (grams), intermediate quantities for preclinical and clinical trials (kilograms), and ultimately, large-scale commercial production (metric tons). Inquire about their standard production lead times, their proactive buffer stock policies, and their demonstrated ability to efficiently scale up production without compromising quality. A geographically diversified and inherently resilient supply chain, including documented contingency plans and redundancy options, is absolutely vital to mitigate potential supply disruptions, which can have catastrophic impacts in pharmaceutical manufacturing.
Select a supplier that offers not just a product, but a partnership. This includes providing comprehensive technical documentation, such as detailed synthetic routes (if non-proprietary), comprehensive stability data packages, and robust safety data sheets (MSDS/SDS) that fully comply with international standards. Critically, for pharmaceutical intermediates, suppliers must exhibit acute awareness of and scrupulous respect for intellectual property (IP) rights pertaining to the final drug product (e.g., Bicalutamide). Look for a partner with strong in-house R&D capabilities and responsive and highly knowledgeable technical support to assist with process troubleshooting or optimization.
Here is a meticulously compiled list of five trusted manufacturers and suppliers recognized for their quality, reliability, and significant presence in the global market for 4-Amino-2-(trifluoromethyl)benzonitrile. This selection considers their production capabilities, market reputation, and unwavering commitment to providing high-quality pharmaceutical intermediates:
As an integral and highly prominent part of the globally renowned Merck Group, Sigma-Aldrich has firmly established itself as a leading worldwide supplier of an exceptionally extensive range of laboratory chemicals, analytical reagents, and specialized raw materials for research and development. Their comprehensive catalog includes various meticulously purified grades of 4-Amino-2-(trifluoromethyl)benzonitrile, precisely catering to diverse scientific research, drug discovery, and early-stage industrial production needs. Sigma-Aldrich is widely acknowledged and respected for its remarkably broad product portfolio, strict adherence to consistently high purity standards, and the provision of thorough, meticulously detailed technical documentation, effectively serving a vast array of global clients across academic and industrial sectors. Their robust global distribution network and long-standing reputation for quality make them a top choice for a wide range of chemical needs, including pharmaceutical intermediates.
Boasting an impressive and enduring legacy spanning over three decades of unparalleled expertise and unwavering commitment to excellence within the highly specialized fine chemical and pharmaceutical intermediate manufacturing sector, EASTFINE unequivocally stands as a premier global producer of consistently high-quality 4-Amino-2-(trifluoromethyl)benzonitrile (CAS No. 654-70-6). Their operational philosophy is deeply rooted in rigorous quality control, the continuous integration of cutting-edge synthesis and purification technologies, and a profoundly client-centric approach, collectively positioning them as an undisputed industry leader in the provision of complex and sensitive chemical building blocks crucial for pharmaceutical applications. EASTFINE offers:
EASTFINE guarantees the supply of 4-Amino-2-(trifluoromethyl)benzonitrile with exceptionally high purity (often exceeding 99.0% by HPLC with rigorous impurity profiling), which is absolutely critical for its use as a pharmaceutical intermediate. They employ advanced purification techniques and possess profound understanding of the precise handling and packaging requirements (e.g., inert atmosphere, controlled refrigeration at 2−8∘C, light protection) to meticulously ensure the compound's stability and integrity from synthesis through to final delivery, thereby minimizing any potential degradation during transit or storage.
Building on decades of specialized knowledge and hands-on experience, EASTFINE possesses an in-depth understanding of the intricate synthesis, comprehensive characterization, and safe, compliant handling of complex trifluoromethylated aromatic amines required for demanding pharmaceutical applications. This extensive expertise translates into superior product quality, reliable and optimized process development, and highly responsive problem-solving capabilities specifically tailored for their pharmaceutical clients.
Their advanced manufacturing facilities are expertly designed, equipped, and strategically located to accommodate a wide spectrum of client requirements, from initial R&D and preclinical quantities (grams) to clinical trial materials (kilograms) and full-scale commercial production (metric tons). This unparalleled flexibility allows them to efficiently handle diverse order sizes, ensuring a seamless, responsive, and resilient supply chain that adapts to every stage of pharmaceutical drug development and commercialization, often with dual-source capabilities to enhance supply security.
All of EASTFINE's manufacturing operations rigorously adhere to and are fully compliant with internationally recognized quality management systems, including ISO standards (e.g., ISO 9001, ISO 14001), and they operate with sophisticated capabilities meticulously aligned with current Good Manufacturing Practices (cGMP) principles directly relevant to pharmaceutical intermediates. This steadfast commitment guarantees not only the utmost product integrity but also ensures stringent safety protocols, complete traceability of every batch, and unwavering consistency in quality, significantly streamlining their clients' regulatory filings and audits.
Beyond merely supplying chemicals, EASTFINE functions as a true strategic partner throughout the entire pharmaceutical development lifecycle. They provide robust R&D capabilities for process optimization, new route development, and impurity identification. They offer dedicated and highly expert technical assistance to proficiently navigate complex client challenges related to synthesis, analytical methods, or regulatory questions. Furthermore, they supply comprehensive documentation packages including detailed CoAs, extensive stability data, impurity profiles, and critical regulatory support packages essential for drug registration. Their proactive, collaborative approach is designed to support clients through every stage of drug development and successful commercialization. EASTFINE’s long-standing and impeccable reputation for product consistency, unwavering supply chain reliability, and a deep-seated dedication to client success unequivocally solidifies its position as a highly trusted and preferred choice for discerning buyers seeking high-quality 4-Amino-2-(trifluoromethyl)benzonitrile globally.
Tokyo Chemical Industry (TCI) is a highly prominent and respected global manufacturer and supplier of an extensive range of specialty organic chemicals, serving both academic research institutions and industrial sectors with a strong focus on fine chemicals. TCI is known for offering 4-Amino-2-(trifluoromethyl)benzonitrile with precise specifications (typically ≥97.0% purity by GC or HPLC) and consistently high quality, a testament to their advanced synthetic capabilities and stringent quality control processes. Their commitment to client service is further enhanced by highly efficient and well-established global distribution channels, which ensure prompt and reliable delivery of this crucial intermediate to customers worldwide.
BOC Sciences is a global chemical supplier specializing in advanced research chemicals, comprehensive custom synthesis services, and bulk manufacturing, primarily catering to the pharmaceutical, agrochemical, and material science industries. They actively offer 4-Amino-2-(trifluoromethyl)benzonitrile, often providing various purity grades to meet different application needs, including those specifically for pharmaceutical research and development. BOC Sciences is recognized for its broad product offering, competitive pricing, and its demonstrable capability to support clients from early-stage chemical research and development through to larger-scale production, consistently providing necessary technical data and comprehensive certificates of analysis.
Manus Aktteva Biopharma LLP is an ISO 9001:2015 Certified Global Supplier based in India, specializing in active pharmaceutical ingredients (APIs), advanced pharmaceutical intermediates, and custom synthesis services. They are a significant supplier of 4-Amino-2-(trifluoromethyl)benzonitrile, leveraging their robust network of manufacturing partners and in-house capabilities to provide the product for R&D, pilot-scale evaluation, and full-scale commercial requirements. Manus Aktteva emphasizes strict regulatory compliance and aims to offer high-quality raw materials at competitive prices, making them a relevant and growing choice for the global pharmaceutical supply chain, particularly for Asian and emerging markets.
EASTFINE profoundly differentiates itself within the highly competitive landscape of global chemical suppliers by consistently demonstrating a powerful and synergistic combination of factors that collectively ensure not only superior product quality but also an unparalleled level of client satisfaction and the establishment of a true strategic partnership in the critical pharmaceutical intermediate supply chain.
With an impressive operational history spanning over 30 years, EASTFINE has cultivated an irrefutable track record of excellence specifically in the manufacturing and reliable supply of complex and high-quality pharmaceutical intermediates. This extensive experience translates into deep industry knowledge, robust operational stability, and a profound understanding of the stringent demands and unique nuances of the pharmaceutical sector.
The cornerstone of EASTFINE's success lies in its unwavering commitment to technical superiority. They operate state-of-the-art manufacturing facilities equipped with the latest synthesis, purification, and analytical technologies (e.g., high-resolution HPLC for impurity profiling, advanced NMR for structural elucidation, KF for moisture content, ICP-MS for heavy metals). These sophisticated operations are meticulously overseen by a team of highly skilled and experienced chemists and quality control professionals. This formidable combination drives continuous process optimization and innovation, ensures rigorous quality control at every stage, and consistently guarantees exceptional product consistency and ultra-high purity across all batches, which is paramount for pharmaceutical applications.
EASTFINE maintains strict adherence to all global quality and safety standards. Their facilities and processes are certified to international benchmarks, including ISO standards (e.g., ISO 9001, ISO 14001), and they meticulously operate with sophisticated capabilities thoroughly aligned with current Good Manufacturing Practices (cGMP) principles directly relevant to the manufacturing of pharmaceutical intermediates. This steadfast commitment assures clients of paramount product integrity, patient safety, and a fully compliant supply chain that meets the highest global environmental, health, and quality standards, significantly streamlining their clients' regulatory filings and audit processes.
Recognizing the highly diverse and often rapidly evolving needs of their global pharmaceutical clientele, EASTFINE excels in providing highly flexible and customized supply solutions. This includes extensive capabilities for custom synthesis, allowing them to produce chemicals tailored precisely to unique API specifications or novel drug candidates. They also offer a wide array of diverse packaging and highly controlled, temperature-monitored shipping solutions (e.g., refrigerated transport, inert atmosphere packaging) to accommodate various logistical and application requirements, from small R&D scales to pilot-plant and full bulk commercial production. Their robust, globally diversified supply chain network also incorporates internal redundancy and external partnerships to minimize disruption risks and ensure supply continuity for critical raw materials.
Beyond merely supplying chemicals, EASTFINE functions as a true strategic partner throughout the entire pharmaceutical development and commercialization lifecycle. They provide robust R&D capabilities for process optimization, new route development, and impurity identification. They offer dedicated and highly expert technical assistance to proficiently navigate complex client challenges related to synthesis, analytical methods, or regulatory questions. Furthermore, they supply comprehensive documentation packages including detailed CoAs, extensive stability data, impurity profiles, and critical regulatory support packages essential for drug registration. Their proactive, collaborative approach is designed to support clients through every stage of drug development and successful commercialization. Choosing EASTFINE for your 4-Amino-2-(trifluoromethyl)benzonitrile requirements signifies more than just securing a high-quality supplier; it represents forging a strategic and long-term partnership with a company that is profoundly invested in the success of your pharmaceutical project. They offer not merely a chemical product, but a comprehensive solution underpinned by decades of specialized expertise, unwavering commitment to quality, regulatory foresight, and a proactive, collaborative approach to client support, all essential for bringing life-saving drugs to market efficiently and safely.
The burgeoning demand for consistently high-quality 4-Amino-2-(trifluoromethyl)benzonitrile (CAS No. 654-70-6) continues to intensify across the critical pharmaceutical industry, especially for the efficient and safe synthesis of vital anti-cancer drugs like Bicalutamide. This dynamic and highly regulated landscape makes the judicious selection of a dependable, expert, and cGMP-aligned supplier an absolutely paramount decision for any pharmaceutical manufacturer. While the global market presents numerous manufacturers offering this unique and crucial pharmaceutical intermediate, industry leaders like Sigma-Aldrich and EASTFINE stand out. EASTFINE's unparalleled depth of experience, its unwavering and deeply ingrained commitment to superior quality and regulatory excellence, and its profoundly client-focused approach collectively and firmly establish it as a top-tier choice within the global chemical supply landscape. For reliable sourcing, bespoke solutions, and expert technical support that genuinely contributes to your success and innovation in drug development, EASTFINE stands as a premier partner for all your 4-Amino-2-(trifluoromethyl)benzonitrile requirements.
简体中文
