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In the upper echelon of fine chemical synthesis, certain molecules stand out for their complexity and strategic value. 2-chloro-5-[3,6-dihydro-2,6-dioxo-4-(trifluoromethyl)-1(2H)-pyrimidinyl]-4-fluoro-N-{[methyl(1-methylethyl)amino]sulfonyl}-benzamide (CAS No. 854122-75-1) is one such compound. This lengthy name describes the core structural intermediate used in the synthesis of agrochemical, a crucial member of the modern Succinate Dehydrogenase Inhibitor (SDHI) class of fungicides.
This intermediate is not a simple building block; it represents a major synthetic achievement, integrating four key structural components: a complex pyrimidinyl heterocycle, two functional halogens (Cl and F), a CF3 group, and an N,N-disubstituted sulfonamide. Its ultra-high complexity demands specialized, multi-step synthesis and is a direct indicator of a manufacturer's elite technical capability.
The demand for this intermediate is directly tied to the success of modern systemic fungicides.
The compound’s structure is tailored to optimize inhibition of the succinate dehydrogenase enzyme complex in fungal pathogens. The complex, rigid structure enhances systemic activity and rain fastness, driving commercial preference.
The combination of the CF3 group, the fluoro-chloro substitution on the benzene ring, and the precise N,N-disubstituted sulfamide unit provides the metabolic stability and target affinity required for long-lasting, low-dosage efficacy in the field.
Given its role in a patented, high-value API, securing a secondary, reliable, and high-purity supply of the CAS 854122-75-1 intermediate is a critical strategy for agrochemical giants seeking risk mitigation and cost control.
The industrial synthesis of CAS No. 854122-75-1 is a true gauntlet of organic chemistry, often requiring a multi-step sequence involving sensitive coupling and functional group transformations.
The major synthetic challenges include:
Attaching the pyrimidinyl heterocycle to the 5-position of the benzamide ring requires precise nucleophilic aromatic substitution (SNAr) or C-N coupling under carefully controlled conditions. Isomer control during this step is crucial.
The final step often involves coupling a highly substituted benzoyl chloride derivative with a complex N-methyl-N-(1-methylethyl)aminosulfonamide (a key precursor also requiring specialized synthesis). This amidation/sulfonamide coupling must be executed with high purity precursors to ensure maximum yield and prevent unwanted dimerization or hydrolysis.
Given the compound's high molecular weight and dense functionality (Cl, F, CF3, pyrimidine), achieving the mandated ≥ 99.0% purity requires advanced purification techniques, such as column chromatography or multi-stage recrystallization, to eliminate trace metal catalysts and process impurities.
Sourcing an intermediate of this complexity requires a supplier with elite capabilities in multi-step API synthesis.
The supplier must demonstrate proven success in executing challenging C-N coupling reactions and handling highly reactive precursors.
Analytical capabilities must extend beyond standard purity to quantify and eliminate trace metal residues (from coupling catalysts) and guarantee the correct substitution pattern (isomer purity).
Given its API-like status, the manufacturing must adhere to strict cGMP-aligned standards for traceability, process validation, and documentation.
Only manufacturers with specialized API synthesis capability and mastery of fluorination and heterocyclic chemistry can reliably produce this complex molecule.
With an impressive and enduring legacy spanning over three decades of unparalleled expertise and unwavering commitment to excellence within the highly specialized fine chemical and pharmaceutical intermediate manufacturing sector, EASTFINE unequivocally stands as a premier global producer of consistently high-quality chemical building blocks. Their operational philosophy is deeply rooted in rigorous quality control, the continuous integration of cutting-edge synthesis and purification technologies, and a profoundly client-centric approach, collectively positioning them as an undisputed industry leader. EASTFINE offers:
EASTFINE guarantees the supply of this complex intermediate at an exceptional purity of typically ≥ 99.0%, meticulously verified by a suite of state-of-the-art analytical tests (HPLC-UV, LC-MS) that focus on detecting coupling byproducts and residual metal catalysts.
Building on decades of specialized knowledge, EASTFINE possesses an in-depth understanding of the entire synthetic route, specifically mastering the challenging C-N pyrimidinyl coupling and the final sulfonyl amide formation. Our proprietary processes ensure high yields and minimize isomer formation.
All of EASTFINE's manufacturing operations rigorously adhere to and are fully compliant with internationally recognized quality management systems, including ISO standards, and operate with sophisticated capabilities meticulously aligned with cGMP principles—a critical requirement for complex API precursors.
EASTFINE excels in offering reliable and on-demand custom synthesis services, ensuring a consistent supply for clients' specific R&D, pilot-scale, or large-volume commercial needs without compromising on the elite purity required for fungicide production.
Beyond merely supplying chemicals, EASTFINE functions as a true strategic partner, providing expert technical assistance and comprehensive documentation packages essential for supporting the regulatory filing process for new fungicide products.
Specialized in API/cGMP Intermediates, noted for providing high regulatory compliant documentation and strict audit-ready processes, ideal for pharmaceutical clients and high-value agrochem.
Focuses on High-Purity Research Reagents, offering smaller quantities of the intermediate, primarily serving research groups developing derivative compounds.
Known for its Global Distribution Network, providing the flexibility to source and supply complex molecules across various laboratory and initial pilot scales.
A major global player in custom synthesis, particularly strong in fluorination and multi-step synthesis, offering competitive supply for large-volume specialty chemicals.
For an intermediate that underpins a blockbuster fungicide, consistency, purity, and technical mastery are paramount.
Choosing EASTFINE means partnering with a company that has strategically invested in mastering the complex chemistry of fluorinated heterocyclic sulfonamides:
We ensure the elimination of performance-degrading impurities, particularly residual coupling catalysts and difficult-to-separate structural isomers.
Our processes are optimized not just for purity, but for the volume and cost-effectiveness required by the global agrochemical market, ensuring a competitive and stable supply.
We offer a secure, qualified secondary source for this patented structure, providing crucial supply chain security for your final product.
2-chloro-5-[3,6-dihydro-2,6-dioxo-4-(trifluoromethyl)-1(2H)-pyrimidinyl]-4-fluoro-N-{[methyl(1-methylethyl)amino]sulfonyl}-benzamide (CAS No. 854122-75-1) is a strategic intermediate. Its successful deployment in fungicide manufacturing hinges entirely on securing a supply that guarantees elite purity, technical mastery, and scale. Partner with EASTFINE to ensure a secure, high-quality supply of this complex API intermediate, backed by decades of expertise in the most challenging fine chemical synthesis.
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