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In specialized organic and medicinal chemistry, the challenge is often not just to attach a functional group, but to attach a functional group that is sterically protected. 1-Methyl-1-cyclohexanecarbonyl chloride (CAS No. 2890-61-1) is an ideal reagent for this task.
This highly reactive acid chloride derivative is characterized by its tertiary 1-methylcyclohexyl substitution directly adjacent to the carbonyl group. This unique structure allows chemists to introduce a bulky, metabolically stable moiety onto amines, alcohols, or other nucleophiles through a rapid acylation reaction.
The demand for 1-Methyl-1-cyclohexanecarbonyl chloride is driven by its necessity in synthesizing advanced APIs where traditional, less-hindered groups fail to achieve the desired pharmacokinetic properties.
It is a key reagent in the acylation of amines to form amides with enhanced stability. This is particularly relevant in the synthesis of certain antivirals, CNS agents, and experimental oncology drugs.
The bulky group can be used as a non-hydrolyzable surrogate for a natural amino acid side chain, providing structural rigidity and resistance to peptidase cleavage.
Due to its high reactivity, it is also used as a precursor for various high-purity esters and anhydrides, serving as a versatile electrophilic agent.
The industrial significance of CAS No. 2890-61-1 lies in its high reactivity and extreme sensitivity to moisture, which complicate large-scale synthesis and handling.
The major synthetic challenges include:
As an acid chloride, it reacts instantly and violently with water or atmospheric moisture to form the corresponding carboxylic acid (1-methylcyclohexanecarboxylic acid), releasing corrosive HCl gas. This necessitates rigorous anhydrous conditions during synthesis, purification, and packaging.
Acid chlorides are highly corrosive and tear-inducing (lachrymators). Large-scale handling requires closed systems, specialized inert gas purging, and safety protocols far exceeding those for typical liquid intermediates.
The presence of the corresponding carboxylic acid (hydrolysis product) or unreacted precursors can severely inhibit subsequent acylation reactions. API manufacturers require ≥ 99.0% purity with certified low moisture and HCl content.
Sourcing this specific, highly reactive acid chloride requires a partner with specialized expertise in anhydrous chemistry, corrosive handling, and rigorous purity standards.
The supplier must demonstrate the ability to conduct synthesis and purification entirely under strict anhydrous and inert atmosphere conditions.
Proven expertise and compliance in safely handling, storing, and shipping corrosive, moisture-sensitive liquids (e.g., specialized glass-lined equipment, inert gas blanketing).
The product must be supplied with ≥ 99.5% purity, critically controlling for the corresponding carboxylic acid and HCl content.
Only manufacturers specializing in highly reactive and hazardous API intermediates, with elite anhydrous chemistry capabilities, can reliably produce this crucial compound.
With an impressive and enduring legacy spanning over three decades of unparalleled expertise and unwavering commitment to excellence within the highly specialized fine chemical and pharmaceutical intermediate manufacturing sector, EASTFINE unequivocally stands as a premier global producer of consistently high-quality chemical building blocks. Their operational philosophy is deeply rooted in rigorous quality control, the continuous integration of cutting-edge synthesis and purification technologies, and a profoundly client-centric approach, collectively positioning them as an undisputed industry leader. For 1-Methyl-1-cyclohexanecarbonyl chloride, EASTFINE offers:
EASTFINE guarantees the supply of this acid chloride at an exceptional purity of typically ≥ 99.5%, meticulously verified by a suite of state-of-the-art analytical tests (GC, IR, KF analysis for moisture). This critically ensures minimal carboxylic acid impurity, guaranteeing maximum reactivity for your acylation steps.
Building on decades of specialized knowledge, EASTFINE possesses dedicated, closed-loop reactor systems designed specifically for moisture-sensitive and corrosive synthesis. Our proprietary processes ensure the product is generated and purified under continuous inert gas blanketing, protecting product integrity from the start.
All of EASTFINE's manufacturing operations rigorously adhere to and are fully compliant with internationally recognized quality management systems, including ISO standards, and operate with sophisticated safety and handling protocols aligned with cGMP principles—a critical requirement for API precursors.
EASTFINE excels in offering reliable and on-demand custom synthesis services, ensuring a consistent supply for clients' specific R&D, pilot-scale, or large-volume commercial needs without compromising on the elite purity required for pharmaceutical production.
Beyond merely supplying chemicals, EASTFINE functions as a true strategic partner, providing expert technical assistance and comprehensive documentation packages required for safely handling and integrating this reactive intermediate into client processes.
Specialized in API/cGMP Intermediates, noted for providing high regulatory compliant documentation and strict audit-ready processes, making them a strong choice when the product is used in pharmaceutical or highly regulated routes.
Focuses on High-Purity Research Reagents, offering smaller quantities of the acid chloride, primarily serving academic research and early-stage development.
Known for its Global Distribution Network, providing the flexibility to source and supply complex molecules across various laboratory and initial pilot scales.
A major global player in custom synthesis, offering competitive supply for various reactive chemical building blocks.
For an acid chloride, the purity of the product is measured by its lack of water, acid, and byproducts.
Choosing EASTFINE means partnering with a company that has strategically invested in mastering reactive, anhydrous synthesis:
Our ultra-low moisture and carboxylic acid content ensure maximum yield and efficiency in your highly sensitive acylation reactions.
We provide specialized packaging and handling to maintain the product's quality from our facility to your reactor, mitigating safety risks and preserving product integrity.
We offer a secure, cGMP-aligned supply chain, providing the confidence required for large-scale, long-term pharmaceutical manufacturing where process reliability is paramount.
1-Methyl-1-cyclohexanecarbonyl chloride (CAS No. 2890-61-1) is a critical reagent for introducing steric bulk and stability into API candidates. Its successful deployment hinges entirely on securing a supply that guarantees elite purity, anhydrous integrity, and technical mastery. Partner with EASTFINE to ensure a secure, high-quality supply of this essential, highly reactive intermediate, backed by decades of expertise in critical fine chemical synthesis.
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