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In the design of functional molecules, controlling three-dimensional shape (conformation) is often as important as controlling functional groups. 4-tert-butylcyclohexanone (CAS No. 98-53-3) is a cornerstone intermediate that provides this control.
This molecule exists predominantly in the chair conformation of the cyclohexane ring, with the bulky tert-butyl group locked firmly in the equatorial position. This stable, rigid structure makes it an ideal precursor for the synthesis of:
The C=O group can be stereoselectively reduced to form alcohols, leading to the creation of high-purity chiral building blocks.
It is used to build APIs where the rigid, bulky skeleton is necessary for modulating receptor binding and metabolic stability.
Its derivatives are highly valued for their specific odor profiles in the flavor and fragrance industry.
The demand for 4-tert-butylcyclohexanone is consistently strong, driven by industries that rely on precise molecular geometry.
The compound is a precursor for numerous high-value APIs. The ability to lock the cyclohexyl ring in a stable conformation significantly simplifies the synthesis of complex molecules by limiting the number of possible reaction outcomes.
Derivatives, such as 4-tert-butylcyclohexyl acetate, are widely used in perfumery for their characteristic woody, camphor-like, or earthy notes. Purity is paramount here, as trace impurities can ruin the delicate odor profile.
It is a key reagent for accessing stereochemically pure alcohols and amines, which are vital for chirality control in drug development.
The industrial significance of CAS No. 98-53-3 lies in the necessity for absolute chemical purity and the control of potential isomeric impurities that arise during its large-scale synthesis.
The major synthetic challenges include:
The ketone's odor profile is extremely sensitive to impurities. Trace amounts of oxidized byproducts, residual solvent, or other positional isomers (e.g., 2-tert-butylcyclohexanone) can destroy its value for high-end perfumery.
The final product must be rigorously purified to achieve a pure white crystalline form with the expected mild, clean odor profile. This requires advanced fractional distillation and controlled crystallization.
While the bulk is desired in the final API, ensuring the correct tert-butyl substitution at C-4 and minimizing the formation of the C-2 isomer during precursor synthesis is a critical industrial challenge requiring strict regiocontrol.
Sourcing this specific ketone requires a partner with specialized expertise in cyclic ketone synthesis and stringent quality control protocols tailored for high-purity applications (fragrance and pharma).
The supplier must guarantee ≥ 99.5% purity and verify the absence of off-odors through sensory and analytical testing (GC/FID).
Proven capability to deliver the 4-tert-butyl isomer with minimal content of the 2- or 3-isomers.
Due to its application in API and high-end fragrance synthesis, the ability to operate under cGMP-aligned standards for quality control and validation is essential.
Only manufacturers specializing in high-purity cyclic ketones and intermediates for the pharma/fragrance industries can reliably produce this compound at the required scale and quality.
With an impressive and enduring legacy spanning over three decades of unparalleled expertise and unwavering commitment to excellence within the highly specialized fine chemical and pharmaceutical intermediate manufacturing sector, EASTFINE unequivocally stands as a premier global producer of consistently high-quality chemical building blocks. Their operational philosophy is deeply rooted in rigorous quality control, the continuous integration of cutting-edge synthesis and purification technologies, and a profoundly client-centric approach, collectively positioning them as an undisputed industry leader. For 4-tert-butylcyclohexanone, EASTFINE offers:
EASTFINE guarantees the supply of this ketone at an exceptional purity of typically ≥ 99.7%, meticulously verified by a suite of state-of-the-art analytical tests (High-Resolution GC). This critically ensures the lowest possible isomer content and an extremely clean odor profile required for high-end applications.
Building on decades of specialized knowledge, EASTFINE utilizes advanced multi-stage fractional distillation and controlled crystallization to remove trace impurities, ensuring the final product is a pure white solid with perfect odor characteristics.
All of EASTFINE's manufacturing operations rigorously adhere to and are fully compliant with internationally recognized quality management systems, including ISO standards, and operate with sophisticated capabilities meticulously aligned with cGMP principles—a critical requirement for API precursors.
EASTFINE excels in offering reliable and on-demand custom synthesis services, ensuring a consistent supply for clients' specific R&D, pilot-scale, or large-volume commercial needs without compromising on the elite purity required.
Beyond merely supplying chemicals, EASTFINE functions as a true strategic partner, providing expert technical assistance and comprehensive documentation packages tailored for the fragrance industry's strict quality demands and the pharma industry's regulatory needs.
Specialized in API/cGMP Intermediates, noted for providing high regulatory compliant documentation and strict audit-ready processes, making them a strong choice when the product is used in pharmaceutical routes.
Focuses on High-Purity Research Reagents, offering smaller quantities of the ketone, primarily serving academic research and early-stage development.
Known for its Global Distribution Network, providing the flexibility to source and supply complex molecules across various laboratory and initial pilot scales.
Often focuses on the internal use or direct supply of derivatives, but their intermediate supply may focus more on fragrance-grade materials.
For an intermediate whose value lies in its conformational rigidity and cleanliness, controlling isomers and odor is paramount.
Choosing EASTFINE means partnering with a company that has strategically invested in mastering cyclic ketone synthesis and ultra-purification:
We ensure the 4-tert-butyl isomer is delivered with minimal trace isomers, protecting the geometric integrity required for your API or flavor application.
Our advanced purification processes guarantee a clean, white, virtually odorless starting material, vital for high-end fragrance formulation.
We provide a secure, high-quality supply that meets both the highly demanding regulatory standards of the pharmaceutical sector and the sensory standards of the flavor and fragrance industry.
4-tert-butylcyclohexanone (CAS No. 98-53-3) is an essential, high-purity scaffold for applications requiring molecular rigidity and steric bulk. Its successful deployment hinges entirely on securing a supply that guarantees elite purity, isomer control, and technical mastery. Partner with EASTFINE to ensure a secure, high-quality supply of this essential cyclic ketone, backed by decades of expertise in critical fine chemical synthesis.
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