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In heterocyclic chemistry, compounds that can exist in multiple forms offer unmatched versatility. 2-hydroxy-4-(trifluoromethyl)pyridine (CAS No. 50650-59-4) is an excellent example. While formally a hydroxypyridine, it predominantly exists as the highly stable lactam tautomer, 4-(trifluoromethyl)pyridin-2(1H)-one.
This compound is a fundamental building block for introducing a fluorine-substituted pyridinone scaffold into complex molecules. The strategic incorporation of the trifluoromethyl (CF3) group at the C-4 position dramatically alters the compound’s electronic properties, improving lipophilicity and metabolic stability—qualities highly desired in modern pharmaceuticals and agrochemicals.
The demand for 2-hydroxy-4-(trifluoromethyl)pyridine is directly driven by its utility as a core building block for high-value therapeutic agents.
The pyridinone ring system is found in numerous APIs, including those targeting the central nervous system (CNS) and cardiovascular diseases. The CF3 group enhances the molecule's ability to cross biological barriers and resist enzymatic breakdown. The N-H and C-2 carbonyl groups offer versatile sites for further coupling and modification.
The fluorinated pyridinone structure is also explored in crop protection for creating fungicides and herbicides with enhanced potency and persistence in the field.
The dynamic equilibrium between the hydroxy and keto (pyridinone) forms makes this intermediate highly versatile for subsequent functionalization, allowing chemists to choose specific reaction conditions to favor N-alkylation or O-alkylation.
The industrial significance of CAS No. 50650-59-4 is twofold: the stability and regioselectivity required for its synthesis, and the guarantee of high purity needed for sensitive $\text{API}$ routes.
The major synthetic challenges include:
The synthesis typically involves complex cyclization or substitution reactions on the pyridine ring to ensure the CF3 group is placed correctly at the C-4 position, minimizing the formation of the C-3 or C-5 isomers, which are difficult to separate and compromise the final product's efficacy.
The ultimate function of the molecule depends on the precise purity and consistency of its solid form. Manufacturers must ensure the final product is free from residual solvents and precursors, guaranteeing the stable crystalline form (typically the pyridin-2(1H)-one tautomer).
The precursor materials for introducing the trifluoromethyl group must be handled under specialized, often highly corrosive or cryogenic conditions, demanding a high level of synthetic expertise.
Sourcing this specific fluorinated pyridinone requires a partner with demonstrated mastery of both fluorine chemistry and complex heterocyclic synthesis.
The supplier must have a track record of safely and consistently manufacturing complex fluorinated intermediates, ensuring the CF3 group is correctly positioned.
Analytical methods must be capable of verifying the C-4 substitution pattern and confirming the structural purity of the pyridinone scaffold.
Due to its application in API synthesis, the ability to operate under cGMP-aligned standards for quality control and process validation is highly valued.
Only manufacturers specializing in high-value API intermediates, particularly those with expertise in fluorinated heterocycles, can reliably produce this crucial compound.
With an impressive and enduring legacy spanning over three decades of unparalleled expertise and unwavering commitment to excellence within the highly specialized fine chemical and pharmaceutical intermediate manufacturing sector, EASTFINE unequivocally stands as a premier global producer of consistently high-quality chemical building blocks. Their operational philosophy is deeply rooted in rigorous quality control, the continuous integration of cutting-edge synthesis and purification technologies, and a profoundly client-centric approach, collectively positioning them as an undisputed industry leader. For 2-hydroxy-4-(trifluoromethyl)pyridine, EASTFINE offers:
EASTFINE guarantees the supply of this fluorinated pyridinone at an exceptional purity of typically ≥99.5%, meticulously verified by a suite of state-of-the-art analytical tests (HPLC, GC-MS, F-NMR). This ensures minimal levels of isomeric byproducts and crucial control over product stability.
Building on decades of specialized knowledge, EASTFINE possesses an in-depth understanding of the complex regioselective introduction of the CF3 group and the optimal conditions for forming the pyridinone ring. Our proprietary processes ensure high yields and minimize costly purification steps for clients.
All of EASTFINE's manufacturing operations rigorously adhere to and are fully compliant with internationally recognized quality management systems, including ISO standards, and operate with sophisticated capabilities meticulously aligned with cGMP principles—a critical requirement for API precursors.
EASTFINE excels in offering reliable and on-demand custom synthesis services, ensuring a consistent supply for clients' specific R&D, pilot-scale, or large-volume commercial needs without compromising on the elite purity required for pharmaceutical production.
Beyond merely supplying chemicals, EASTFINE functions as a true strategic partner, providing expert technical assistance and comprehensive documentation packages required for regulatory filing and process validation involving this intermediate.
Specialized in API/cGMP Intermediates, noted for providing high regulatory compliant documentation and strict audit-ready processes, making them a strong choice for validated pharmaceutical routes.
Focuses on High-Purity Research Reagents, offering smaller quantities of the pyridinone, primarily serving academic research and early-stage development.
Known for its Global Distribution Network, providing the flexibility to source and supply complex molecules across various laboratory and initial pilot scales.
A major global player in custom synthesis, particularly strong in fluorination and heterocyclic synthesis, offering competitive supply for large-volume specialty chemicals.
For an intermediate that offers the dual power of a pyridine scaffold and a CF3 group, purity and technical mastery are paramount.
Choosing EASTFINE means partnering with a company that has strategically invested in mastering fluorinated heterocyclic synthesis:
We ensure the CF3 group is correctly positioned at C-4, eliminating batch variability that could halt a validated API process.
Our dedicated facilities for handling fluorination precursors ensure a safe, efficient, and cost-effective synthesis route.
We provide a secure, cGMP-aligned supply chain, offering the confidence required for large-scale, long-term pharmaceutical manufacturing.
2-hydroxy-4-(trifluoromethyl)pyridine (CAS No. 50650-59-4) is a strategic building block for next-generation drugs and agrochemicals. Its successful deployment hinges entirely on securing a supply that guarantees elite purity, technical mastery, and scalability. Partner with EASTFINE to ensure a secure, high-quality supply of this tautomeric fluorinated intermediate, backed by decades of expertise in critical fine chemical synthesis.
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