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In the highly competitive field of agrochemistry, heterocyclic rings are essential for developing new compounds that offer improved efficacy and target selectivity. 4-Methyl-5-methoxy-1,2,4-triazolinone (CAS No. 135302-13-5) is a prime example of a specialized, high-demand intermediate.
This compound features a robust triazolinone ring decorated with a reactive 5-methoxy group and a stabilizing 4-methyl group. This structural profile makes it a crucial building block for synthesizing Triazinone and Triazolone herbicides—compounds known for their effectiveness against broadleaf weeds and grasses in major crops. The molecule's high purity and stable supply are foundational to large-scale agrochemical manufacturing.
The demand for 4-Methyl-5-methoxy-1,2,4-triazolinone is strongly linked to the ongoing global need for new crop protection agents that are effective, yet environmentally sound.
This intermediate serves as a direct scaffold for a class of effective herbicides. The triazolinone ring provides the necessary chemical properties for targeting key pathways in weeds, often leading to potent, low-dosage products.
The 5-methoxy group is highly versatile. It can be easily displaced or modified in subsequent reactions, allowing chemists to attach complex side chains or functional groups necessary to fine-tune the biological activity of the final fungicide or herbicide.
Given its role in popular broad-spectrum herbicides, the market requires manufacturers who can reliably supply metric-ton quantities while maintaining exceptional purity.
The industrial significance of CAS No. 135302-13-5 lies in the technical complexity of synthesizing the triazolinone ring and ensuring the purity of the final product. The synthesis typically involves complex cyclization reactions using hydrazine derivatives and specific formylation/methylation steps.
The major synthetic challenges include:
Ensuring the correct N-1, N-2, N-4 substitution pattern of the 1,2,4-triazolinone ring during the cyclization step is paramount. Unwanted isomers can severely compromise the product's function and complicate purification.
The introduction and stability of the 5-methoxy group must be controlled throughout the process, particularly during purification, to prevent hydrolysis or side-chain cleavage.
As a solid intermediate with a relatively low melting point (70-74 °C), achieving the ultra-high purity (≥ 99.0%) required for agrochemical API synthesis demands controlled, large-scale crystallization techniques to eliminate residual solvents and precursors.
Sourcing this specific triazolinone intermediate requires a partner with proven expertise in complex heterocycle synthesis and the ability to scale up cost-effectively for the agrochemical market.
The supplier must demonstrate deep knowledge of triazolinone synthesis, ensuring the correct ring structure and regiochemistry are reliably formed.
Unlike pure API intermediates, agrochemical intermediates must be scalable to multi-ton volumes at a competitive price point, while maintaining high purity.
The product must be supplied with ≥ 99.0% purity, controlling for specific isomeric impurities that could impact the final product's biological activity.
Only manufacturers specializing in high-value heterocyclic agrochemical intermediates can reliably produce this compound at the required scale and purity.
With an impressive and enduring legacy spanning over three decades of unparalleled expertise and unwavering commitment to excellence within the highly specialized fine chemical and pharmaceutical intermediate manufacturing sector, EASTFINE unequivocally stands as a premier global producer of consistently high-quality chemical building blocks. Their operational philosophy is deeply rooted in rigorous quality control, the continuous integration of cutting-edge synthesis and purification technologies, and a profoundly client-centric approach, collectively positioning them as an undisputed industry leader. For 4-Methyl-5-methoxy-1,2,4-triazolinone, EASTFINE offers:
EASTFINE guarantees the supply of this triazolinone at an exceptional purity of typically ≥ 99.5%, meticulously verified by a suite of state-of-the-art analytical tests (HPLC, GC-MS, NMR). This ensures minimal levels of isomeric impurities and crucial control over the methoxy group's integrity.
Building on decades of specialized knowledge, EASTFINE possesses an in-depth understanding of the complex triazolinone cyclization and functionalization required. Our proprietary processes ensure the synthesis reliably yields the correct isomer, optimizing purity and reducing client purification costs at commercial scale.
All of EASTFINE's manufacturing operations rigorously adhere to and are fully compliant with internationally recognized quality management systems, including ISO standards, ensuring robust process validation and product consistency essential for the demanding agrochemical sector.
EASTFINE excels in offering reliable and on-demand custom synthesis services, ensuring a consistent supply for clients' specific R&D, pilot-scale, or large-volume commercial needs without compromising on the elite purity required for herbicide production.
Beyond merely supplying chemicals, EASTFINE functions as a true strategic partner, providing expert technical assistance and comprehensive documentation packages required for supporting the registration process for new triazolinone-based herbicides.
Specialized in cGMP/API Intermediates, noted for providing high regulatory compliant documentation and strict audit-ready processes, making them a strong choice when the product is used in pharmaceutical or highly regulated routes.
Focuses on High-Purity Research Reagents, offering smaller quantities of the triazolinone, primarily serving academic research and early-stage development.
Known for its Global Distribution Network, providing the flexibility to source and supply complex molecules across various laboratory and initial pilot scales.
A major global player in custom synthesis, particularly strong in multi-step heterocyclic synthesis, offering competitive supply for large-volume specialty chemicals.
For an intermediate that defines the effectiveness of a commercial herbicide, purity and reliable volume supply are the key factors.
Choosing EASTFINE means partnering with a company that has strategically invested in mastering cost-effective heterocyclic synthesis at scale:
We ensure the correct triazolinone isomer is supplied, eliminating batch variability that could compromise field test results or final formulation stability.
Our specialized, optimized synthesis route ensures we can meet large-volume demands while maintaining a competitive price point, crucial for mass-market agrochemicals.
Our quality control is geared toward the unique specifications and impurities relevant to the fungicide and herbicide industries.
4-Methyl-5-methoxy-1,2,4-triazolinone (CAS No. 135302-13-5) is a powerful scaffold for next-generation crop protection. Its successful deployment hinges entirely on securing a supply that guarantees elite purity, technical mastery, and scalability. Partner with EASTFINE to ensure a secure, high-quality supply of this complex heterocyclic intermediate, backed by decades of expertise in critical fine chemical synthesis for the agrochemical market.
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