Commercial Sourcing & Market Analysis: Cyclobutanone (CAS No. 1191-95-3)

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Introduction

In global life science manufacturing, Cyclobutanone (CAS No. 1191-95-3) is a specialized cyclic ketone building block. Primarily utilized as a critical pharmaceutical intermediate for complex small-molecule therapeutics, it is also leveraged in advanced agrochemical synthesis to introduce constrained four-membered carbocyclic frameworks into crop protection active ingredients.

Navigating the commercial landscape for Cyclobutanone requires enterprise procurement teams to balance supply stability, total cost of ownership, and strict regulatory compliance across multi-year campaign lifecycles.

Global Market Dynamics & Commercial Drivers

The commercial demand for CAS No. 1191-95-3 is driven by its unique ring strain and synthetic versatility in drug candidate optimization and specialized crop protection chemistry:

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Small-Molecule API Pipeline Growth

Cyclobutanone is a key precursor for active pharmaceutical ingredient pipelines targeting central nervous system disorders, oncology, and antiviral indications. The four-membered carbocyclic ring imparts specific conformational rigidity and lipophilicity to drug candidates, improving metabolic stability and target-receptor binding profiles in human health applications.

High-Value Agrochemical Intermediates

In advanced agrochemical manufacturing, Cyclobutanone serves as a key intermediate for novel selective fungicides, targeted herbicides, and pest-control agents. Incorporating the cyclobutane motif enhances the biological activity of active ingredients, helping overcome resistance patterns in targeted agricultural crop protection programs.

Supply Chain Consolidation & Capacity Risk

Production of high-purity Cyclobutanone requires specialized ring-expansion or oxidation capabilities, concentrating primary manufacturing capacity among established fine chemical producers. As regulatory authorities tighten environmental and safety standards globally, pharma and agrochem sourcing managers prioritize long-term off-take agreements with fully certified primary producers to mitigate supply chain volatility.

Commercial Quality Release Specifications

To ensure seamless integration into multi-step API and agrochemical synthesis, enterprise procurement teams enforce rigorous commercial release specifications:

Quality Parameter	Commercial Release Target	Analytical Method	Sourcing & Campaign Purpose
Appearance	Clear, colorless to pale yellow liquid	Visual Inspection	Verifies absence of particulates, polymer residues, or heavy oxidation.
GC Purity Assay	Equal to or greater than 98.0%	Gas Chromatography (GC-FID)	Guarantees predictable stoichiometry and prevents target reaction yields from dropping.
Moisture Content	Equal to or less than 0.50% (5000 ppm)	Karl Fischer Titration	Prevents hydrolysis and unwanted side-reactions in water-sensitive synthetic steps.
Boiling Point Target	~98 °C to 100 °C	Standard Distillation	Validates thermal stability and batch-to-batch physical identity.
Density (at 20 °C)	~0.930 to 0.940 g/cm³	Digital Densitometer	Ensures accurate liquid metering in automated commercial-scale reactors.

Commercial Logistics & Packaging Stewardship

Given its volatility and reactivity, strict supply chain stewardship is required during storage and international shipping:

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Packaging Standards:

Packaged under an inert dry nitrogen blanket in light-shielded, corrosion-resistant steel drums or specialized ISO tanks to preserve shelf life and prevent premature oxidation.

Storage Conditions:

Kept in temperature-controlled, explosion-proof hazardous material warehouses below 25 °C, strictly segregated from strong reducing agents, bases, and mineral acids.

Dangerous Goods Logistics:

Transport complies with standard international dangerous goods regulations (Flammable Liquid classification) supported by complete Safety Data Sheets (SDS) and batch-specific Certificates of Analysis (CoA).

Strategic Supply Positioning with EASTFINE

Securing multi-ton allocations for regulatory drug filings and seasonal agrochemical campaigns requires a reliable primary manufacturing partner. EASTFINE provides global pharmaceutical and agrochemical companies with supply security, direct primary producer value, and comprehensive technical support:

Dual-Site Production Security (Dalian & Heze)

Single-site dependency creates unacceptable risk during regional audits or facility maintenance. EASTFINE operates two state-of-the-art primary manufacturing facilities in Dalian and Heze.

Uninterrupted Campaign Supply:

Scalable batch production capabilities support clinical trial scaling through to commercial volume demands.

Operational Redundancy:

Flexible production scheduling allows seamless volume allocation between sites to eliminate delivery bottlenecks.

Direct Primary Producer Value

Backed by an experienced internal R&D team holding 19 invention patents and 8 utility model patents, EASTFINE focuses on continuous process optimization and raw material yield efficiency. Sourcing directly from the manufacturer eliminates middleman markups, ensuring competitive contract pricing.

Regulatory Compliance & Quality Systems

Operating under ISO 9001, ISO 14001, and ISO 45001 management standards, EASTFINE delivers full batch traceability, complete Certificates of Analysis (CoAs), Safety Data Sheets (SDS), and direct audit access for customer quality assurance teams.

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Conclusion

Securing a reliable, high-purity supply of Cyclobutanone (CAS No. 1191-95-3) is critical for keeping pharmaceutical development pipelines and agrochemical manufacturing schedules on track. Partnering directly with EASTFINE gives life science companies access to dual-site supply security, consistent quality, and direct factory pricing.

Contact EASTFINE's commercial sales team today to request samples, review technical dossiers, or discuss long-term campaign allocations.