High-Purity Cyclobutanone (CAS No. 1191-95-3) for Advanced Active Pharmaceutical Ingredient Synthesis

Introduction

Cyclobutanone (CAS No. 1191-95-3) is a critical cyclic ketone intermediate designed exclusively for the pharmaceutical synthesis sector. Characterized by its strained four-membered carbocyclic ring and reactive carbonyl handle, this high-value building block enables medicinal chemists and process engineers to incorporate constrained motifs into complex small-molecule active pharmaceutical ingredients (APIs).

To secure seamless campaign execution and regulatory compliance, global pharmaceutical procurement leaders and process development teams must align material quality, physical specifications, and multi-site production reliability across the entire drug development lifecycle.

Strategic Value in Active Pharmaceutical Ingredient Synthesis

The utility of CAS No. 1191-95-3 in pharmaceutical R&D and commercial API manufacturing stems directly from its unique thermodynamic ring strain and synthetic versatility:

Small-Molecule API Pipeline Development

In human health applications, incorporating the four-membered cyclobutane framework enhances the conformational rigidity of drug candidates. This structural restriction frequently improves target-receptor selectivity, increases metabolic stability against enzymatic breakdown, and modulates lipophilicity. It is widely deployed across active drug development pipelines targeting central nervous system (CNS) conditions, oncology therapeutic pathways, cardiovascular treatments, and antiviral agents.

Ring-Expansion & Photochemical Transformations

Beyond direct functionalization, process chemistry groups utilize Cyclobutanone in ring-opening, ring-expansion, and photochemical cycloaddition routes. These reactions unlock access to intricate heterocycles, spirocyclic centers, and bicyclic core structures that are otherwise difficult or cost-prohibitive to synthesize through conventional open-chain chemistry.

High-Yield Coupling in Multi-Step Synthesis

The electron-deficient carbonyl carbon allows for high-yield nucleophilic additions, reductive aminations, and Wittig reactions. Maintaining high chemical purity ensures that competing side reactions are minimized, preserving precious late-stage drug intermediates during multi-step API synthesis.

Commercial Quality Release & Physical Specifications

Integrating raw materials into multi-step downstream pharmaceutical campaigns requires strict quality controls to prevent batch variations, yield loss, or trace impurities:

Handling, Logistics & Packaging Standards

Given its volatile and flammable liquid characteristics, Cyclobutanone demands comprehensive supply chain management and safe handling protocols:

Inert Packaging:

Transported under a dry nitrogen purge in light-shielded steel drums or dedicated ISO tank containers to maintain product stability and avoid ambient moisture uptake.

Storage Protocols:

Maintained in cool, dry, explosion-proof storage facilities below 25 °C, strictly separated from strong bases, reducing agents, and oxidizing agents.

Global Logistics Compliance:

Fully classified under international dangerous goods regulations (Flammable Liquid, Hazardous Class 3) and shipped with complete Safety Data Sheets (SDS) and lot-specific Certificates of Analysis (CoA).

Primary Manufacturer Advantage: EASTFINE

For high-volume commercial API campaigns and clinical supply, sourcing from a vetted primary producer is essential for maintaining supply continuity and controlling total manufacturing costs. EASTFINE supports global pharmaceutical developers with integrated production capabilities:

Dual-Site Infrastructure (Dalian & Heze)

Single-source manufacturing poses operational risks during environmental inspections or facility turnarounds. EASTFINE operates two production facilities located in Dalian and Heze. This dual-site footprint guarantees redundant production pathways, enabling flexible scheduling and uninterrupted volume delivery from pilot-scale clinical batches up to metric-ton commercial supply.

In-House R&D & Patent Portfolio

Supported by a dedicated chemical research team holding 19 invention patents and 8 utility model patents, EASTFINE focuses on route optimization, atom economy, and yield maximization. Purchasing directly from a primary producer avoids trading company margins and provides direct communication with production chemists.

Integrated Quality Management Systems

EASTFINE facilities operate under ISO 9001, ISO 14001, and ISO 45001 management standards. Every batch undergoes full analytical verification, complete lot traceability, and raw data archiving to support global regulatory filings and customer audit requirements.

Summary

Securing a consistent, high-purity supply of Cyclobutanone (CAS No. 1191-95-3) is critical for advancing complex pharmaceutical pipelines without campaign delays. By combining dual-site production security with direct manufacturer value, EASTFINE serves as a dependable chemical supply partner for the global pharmaceutical industry.

Contact EASTFINE's commercial sales team to obtain technical packages, request evaluation samples, or arrange campaign allocations.