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Cyclobutanone (CAS No. 1191-95-3) is a highly specialized, cyclic ketone building block designed specifically for advanced small-molecule active pharmaceutical ingredient (API) synthesis. Defined by its strained four-membered carbocyclic ring (C4H6O) and electron-deficient carbonyl group, this versatile synthon serves as an essential structural platform for medicinal chemistry R&D, clinical trial manufacturing, and commercial-scale API production.
For global pharmaceutical procurement directors, process safety leads, and chemical development leads, managing the commercial lifecycle of Cyclobutanone requires evaluating its synthetic behavior, analytical specifications, safe logistics handling, and primary supply chain partners.
The strategic value of CAS No. 1191-95-3 in active pharmaceutical ingredient development stems directly from its thermodynamic geometry and broad chemical reactivity:
In modern drug discovery, replacing flexible aliphatic chains with rigid four-membered rings is a proven strategy for modulating pharmacokinetic profiles. The cyclobutane ring provides precise spatial positioning of side chains, which can:
Restricting conformational movement maximizes key target-receptor interactions within enzymatic binding pockets.
The strained carbocyclic core slows enzymatic oxidation, extending systemic half-life in human drug candidates.
Incorporating cyclobutane motifs modulates lipophilicity (log P), aqueous solubility, and overall drug permeability across biological membranes.
Cyclobutanone derivatives are deployed across active discovery and commercial drug production pipelines, including:
Serving as a scaffold for rigid neurotransmitter analogues and centrally acting therapeutics.
Supplying key intermediate fragments for targeted cancer therapies and small-molecule enzyme inhibitors.
Utilizing photochemical cycloadditions to build bicyclic nucleosides and modified isonucleoside analogues.
The electrophilic carbonyl carbon paired with ~26 kcal/mol of ring strain enables high-yielding synthetic transformations under controlled conditions:
Generates sterically hindered tertiary cyclobutanols without side-reaction pathways.
Converts to aminocyclobutane derivatives for direct coupling into peptide-like backbones or amide linkages.
Undergoes Baeyer-Villiger oxidations or homologation reactions to access functionalized gamma-lactones, spirocyclic centers, and substituted heterocycles that are difficult to construct via linear pathways.
Due to its volatile liquid profile, flammable classification, and environmental sensitivity, Cyclobutanone requires rigorous supply chain management and storage stewardship:
Standard commercial packaging utilizes light-shielded steel drums or dedicated stainless steel ISO tanks purged with dry nitrogen gas to prevent moisture absorption and oxidation.
Stored in cool, dry, explosion-proof hazardous chemical warehouses below 25 °C (or refrigerated at 0–6 °C for long-term storage), segregated from strong bases, reducing agents, and mineral acids.
Fully classified under international dangerous goods regulations (Flammable Liquid, Class 3, UN 1224, Packing Group II/III) and shipped with complete Safety Data Sheets (SDS) and lot-specific Certificates of Analysis (CoA).
For high-volume API manufacturing, partnering with a primary producer ensures supply chain continuity, batch consistency, and direct pricing transparency. EASTFINE supports global life science and fine chemical companies through an integrated industrial infrastructure:
Single-site chemical supply chains expose pharmaceutical projects to disruption during environmental audits, maintenance turnarounds, or regional restrictions. EASTFINE maintains two primary production operations in Dalian and Heze:
Provides continuous production capability with seamless fallback options to prevent project delays.
Accommodates demand shifts from multi-kilogram pilot batches for clinical trials up to multi-ton commercial production runs.
EASTFINE operates dedicated research laboratories staffed by doctoral organic chemists. Holding 19 invention patents and 8 utility model patents, the technical team continually refines synthesis routes (such as cyclization of gamma-butyrolactone or selective oxidation protocols) to maximize atom economy, lower byproduct formation, and ensure pure material output. Sourcing directly from the primary manufacturer removes intermediary markups while opening direct technical lines to reaction engineers.
EASTFINE facilities operate under strict ISO 9001, ISO 14001, and ISO 45001 management frameworks. Every production batch undergoes full spectrum analysis (GC-MS, HPLC, Karl Fischer, and NMR). Complete lot traceability, archival sample retention, and comprehensive analytical documentation support global regulatory filings and customer facility audits.
Securing a consistent, high-purity supply of Cyclobutanone (CAS No. 1191-95-3) is critical for advancing complex small-molecule drug candidates without campaign interruptions. By pairing dual-site manufacturing resilience with primary producer expertise, EASTFINE provides global pharmaceutical companies with a dependable chemical sourcing partnership.
Contact EASTFINE's commercial sales team to request evaluation samples, review technical dossiers, or arrange campaign volume allocations.
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