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In complex fine chemical manufacturing, fused heterocycles—where two or more ring systems share common atoms—are prized for their unique biological activity and structural rigidity. 5,7-dimethoxy-[1,2,4]triazolo[1,5-a]pyrimidin-2-amine (CAS No. 13223-43-3) is a prime example of this elite class.
This molecule contains the structurally significant triazolo[1,5-a]pyrimidine core, which is highly prevalent in modern agrochemical fungicides (e.g., triazolopyrimidine sulfonanilide fungicides) and is also explored in anti-inflammatory and CNS drug development. The presence of two electron-donating methoxy groups and a reactive primary amine (NH2) allows for unparalleled chemical versatility in downstream synthetic steps.
The demand for 5,7-dimethoxy-[1,2,4]triazolo[1,5-a]pyrimidin-2-amine is driven by its ability to serve as a high-value, multifunctional starting material across multiple industries.
This compound forms the core scaffold of several highly effective systemic fungicides. The fused heterocyclic ring structure enhances the compound's stability and systemic action within plants, driving its consistent demand in the global crop protection market.
The compound is utilized for synthesizing novel API candidates. The primary amine at C-2 is an ideal site for coupling with acids or isocyanates to form amides or ureas, while the methoxy groups can be selectively cleaved or substituted.
The fused ring system provides a rigid, pre-organized structure that is often beneficial in drug design for optimizing receptor binding affinity.
The industrial synthesis of CAS No. 13223-43-3 is technically demanding, requiring expertise in constructing complex fused rings and managing multiple reactive functional groups.
The major synthetic challenges include:
The synthesis involves a multi-step cyclization (often starting from aminotriazole precursors) to form the fused pyrimidine ring. Achieving high yields and absolute regioselectivity is paramount to avoid forming unwanted isomers (e.g., triazolo[1,5-c]pyrimidine derivatives), which would be extremely difficult to separate.
While the methoxy groups are strategic, their introduction and subsequent handling must be carefully controlled to prevent hydrolysis or side-reaction, ensuring they are preserved until the final functionalization step by the client.
The primary amine (NH2) at C-2 is often the site of a crucial coupling reaction. Trace impurities, particularly residual acids or bases from the synthesis, can poison these steps, necessitating an ultra-high purity standard (≥ 99.0%).
Sourcing this specific fused heterocycle requires a partner with specialized expertise in complex ring systems and demonstrated ability to scale up with consistent quality for both the agrochemical and pharmaceutical markets.
The supplier must demonstrate deep knowledge of triazolo[1,5-a]pyrimidine synthesis, ensuring the correct ring fusion and regiochemistry are reliably formed.
The product must be supplied with ≥ 99.5% purity, critically controlling for impurities that might inhibit subsequent coupling or acylation reactions at the amino group.
Due to its application in API and high-value agrochemical synthesis, the ability to operate under cGMP-aligned standards for quality control and process validation is essential.
Only manufacturers specializing in high-value, multi-functional fused heterocyclic intermediates can reliably produce this complex compound at the required scale and purity.
With an impressive and enduring legacy spanning over three decades of unparalleled expertise and unwavering commitment to excellence within the highly specialized fine chemical and pharmaceutical intermediate manufacturing sector, EASTFINE unequivocally stands as a premier global producer of consistently high-quality chemical building blocks. Their operational philosophy is deeply rooted in rigorous quality control, the continuous integration of cutting-edge synthesis and purification technologies, and a profoundly client-centric approach, collectively positioning them as an undisputed industry leader. For 5,7-dimethoxy-[1,2,4]triazolo[1,5-a]pyrimidin-2-amine, EASTFINE offers:
EASTFINE guarantees the supply of this fused heterocycle at an exceptional purity of typically ≥ 99.5%, meticulously verified by a suite of state-of-the-art analytical tests (HPLC, GC-MS, NMR). This critically ensures the absence of structural isomers and guarantees the integrity of the highly reactive C-2 amine.
Building on decades of specialized knowledge, EASTFINE possesses an in-depth understanding of the complex cyclization chemistry required for the triazolo[1,5-a]pyrimidine scaffold. Our proprietary processes ensure absolute regioselectivity in the ring formation, minimizing costly purification steps for clients.
All of EASTFINE's manufacturing operations rigorously adhere to and are fully compliant with internationally recognized quality management systems, including ISO standards, and operate with sophisticated capabilities meticulously aligned with cGMP principles—a critical requirement for high-value API and agrochemical precursors.
EASTFINE excels in offering reliable and on-demand custom synthesis services, ensuring a consistent supply for clients' specific R&D, pilot-scale, or large-volume commercial needs without compromising on the elite purity required for pharmaceutical and agrochemical production.
Beyond merely supplying chemicals, EASTFINE functions as a true strategic partner, providing expert technical assistance and comprehensive documentation packages required for supporting the regulatory filing process involving this crucial fused heterocyclic intermediate.
Specialized in cGMP/API Intermediates, noted for providing high regulatory compliant documentation and strict audit-ready processes, making them a strong choice when the product is used in pharmaceutical or highly regulated routes.
Focuses on High-Purity Research Reagents, offering smaller quantities of the triazolopyrimidine, primarily serving academic research and early-stage development.
Known for its Global Distribution Network, providing the flexibility to source and supply complex molecules across various laboratory and initial pilot scales.
A major global player in custom synthesis, particularly strong in multi-step heterocyclic synthesis, offering competitive supply for large-volume specialty chemicals.
For an intermediate that offers three sites for functionalization, the structural integrity and purity of the scaffold are the ultimate measure of quality.
Choosing EASTFINE means partnering with a company that has strategically invested in mastering fused heterocyclic synthesis at scale:
We ensure the correct triazolo[1,5-a]pyrimidine isomer is supplied, eliminating structural impurities that compromise API or fungicide efficacy.
Our ultra-high purity guarantees the reactivity of the C-2 amine, ensuring maximum yield in your subsequent acylation or coupling reactions.
We provide a secure, cGMP-aligned supply chain, offering the confidence required for both long-term pharmaceutical and large-volume agrochemical manufacturing.
5,7-dimethoxy-[1,2,4]triazolo[1,5-a]pyrimidin-2-amine (CAS No. 13223-43-3) is a strategic, multifunctional core for next-generation fungicides and pharmaceuticals. Its successful deployment hinges entirely on securing a supply that guarantees elite purity, technical mastery, and scalability. Partner with EASTFINE to ensure a secure, high-quality supply of this essential fused heterocyclic intermediate, backed by decades of expertise in critical fine chemical synthesis.
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