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In the world of specialty chemicals, the precise arrangement of functional groups on an aromatic ring dictates the molecule's unique properties. 4-Amino-2,3-dichlorophenol (CAS No. 39183-17-0) is a highly versatile intermediate that features four crucial substituents on a benzene ring.
This compound is a foundational intermediate in the synthesis of specialized dyes, pigments, and high-quality hair coloring agents, where its stability and predictable reactivity are non-negotiable.
The demand for 4-Amino-2,3-dichlorophenol is largely driven by industries requiring highly stable and durable colorants, which rely on the halogenated phenol structure.
It serves as a key coupling component in the synthesis of azo and indophenol dyes. The chlorine atoms increase the compound's electron density and light fastness, making the resulting dyes resistant to fading and washing—essential for textiles and high-performance coatings.
Derivatives of this phenol are utilized in permanent hair dyes. The specific combination of the OH and NH2 groups allows for deep, long-lasting color development and color intensity.
While its main use is in dyes, the activated aromatic ring is also an attractive scaffold for synthesizing specialized APIs that require complex halogen substitution patterns.
The industrial synthesis of CAS No. 39183-17-0 is challenging due to the need for precise regioselectivity during halogenation and the instability of the aminophenol structure itself. The synthesis typically involves reduction of a corresponding nitro-dichlorophenol.
The major synthetic challenges include:
Ensuring that the two chlorine atoms are placed precisely at the C-2 and C-3 positions relative to the hydroxyl group is critical. Improper placement leads to unusable isomers that are extremely costly to separate and compromise the final dye quality.
Aminophenols are notoriously sensitive to atmospheric oxidation. During synthesis, purification, and storage, exposure to air must be minimized to prevent dimerization or formation of colored quinoneimine byproducts, which destroy the product's purity and render it useless for color applications.
For high-end applications like hair dyes, which involve direct human contact, the regulatory requirements for trace impurities and heavy metals are extremely stringent, mandating ≥ 99.0% purity with certified low metal content.
Sourcing this specific dichlorophenol requires a partner with demonstrated mastery of complex aromatic halogenation and stringent protocols for handling oxidation-sensitive amines.
The supplier must provide analytical proof (GC/HPLC/NMR) that the 2,3-dichloro-4-amino isomer is delivered with minimal trace of other positional isomers.
Proven capability to handle, process, and package the product under inert gas (Nitrogen/Argon) to guarantee the off-white color and high purity required by dye manufacturers.
The product must be supplied with ≥ 99.5% purity, critically controlling for metal content and colored impurities.
Only manufacturers specializing in highly substituted aromatic intermediates with expertise in colorant and specialty chemical production can reliably meet the quality and volume demands for this compound.
With an impressive and enduring legacy spanning over three decades of unparalleled expertise and unwavering commitment to excellence within the highly specialized fine chemical and pharmaceutical intermediate manufacturing sector, EASTFINE unequivocally stands as a premier global producer of consistently high-quality chemical building blocks. Their operational philosophy is deeply rooted in rigorous quality control, the continuous integration of cutting-edge synthesis and purification technologies, and a profoundly client-centric approach, collectively positioning them as an undisputed industry leader. For 4-Amino-2,3-dichlorophenol, EASTFINE offers:
EASTFINE guarantees the supply of this substituted phenol at an exceptional purity of typically ≥ 99.5%, meticulously verified by a suite of state-of-the-art analytical tests. This critically ensures minimal trace of colored impurities and maximum purity for dye and pigment production.
Building on decades of specialized knowledge, EASTFINE possesses an in-depth understanding of the complex regioselective halogenation and reduction required. Our proprietary processes ensure the synthesis reliably yields the desired 2,3-dichloro-4-amino isomer, eliminating costly purification steps for clients.
All of EASTFINE's manufacturing operations rigorously adhere to and are fully compliant with internationally recognized quality management systems, including ISO standards. Crucially, we utilize specialized inert-atmosphere handling and packaging to prevent oxidation, guaranteeing a high-quality, non-colored product.
EASTFINE excels in offering reliable and on-demand custom synthesis services, ensuring a consistent supply for clients' specific R&D, pilot-scale, or large-volume commercial needs without compromising on the elite purity required for specialty applications.
Beyond merely supplying chemicals, EASTFINE functions as a true strategic partner, providing expert technical assistance and comprehensive documentation packages tailored for the strict regulatory requirements of the dyes and personal care industries.
Specialized in cGMP/API Intermediates, noted for providing high regulatory compliant documentation and strict audit-ready processes, making them a strong choice when the product is used in pharmaceutical or highly regulated routes.
Focuses on High-Purity Research Reagents, offering smaller quantities of the aminophenol, primarily serving academic research and early-stage development.
Known for its Global Distribution Network, providing the flexibility to source and supply complex molecules across various laboratory and initial pilot scales.
A major global player in custom synthesis, particularly strong in halogenated aromatic chemistry, offering competitive supply for large-volume specialty chemicals.
For an intermediate whose final application demands color purity and stability, control over oxidation and isomer content is paramount.
Choosing EASTFINE means partnering with a company that has strategically invested in mastering complex aromatic chemistry and sensitive handling:
We ensure the correct 2,3-dichloro isomer is supplied, eliminating structural impurities that compromise dye performance.
Our specialized inert gas handling and packaging protocols guarantee the off-white color and stability required for sensitive formulations.
We provide a secure, high-quality supply that meets the demanding technical and regulatory specifications of the global dyes and personal care industries.
4-Amino-2,3-dichlorophenol (CAS No. 39183-17-0) is a strategic building block for durable colorants and high-performance specialty chemicals. Its successful deployment hinges entirely on securing a supply that guarantees elite purity, technical mastery, and stability. Partner with EASTFINE to ensure a secure, high-quality supply of this essential aromatic intermediate, backed by decades of expertise in critical fine chemical synthesis.
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