Top 10 Manufacturers of Agrochemical Intermediate CAS No. 114776-15-7 in 2025

Understanding Ethyl 2-chloro-4-fluorobenzoylacetate (CAS No. 114776-15-7)

Ethyl 2-chloro-4-fluorobenzoylacetate (CAS No. 114776-15-7) is a key intermediate used in the synthesis of selective herbicides and insecticides. The presence of chlorine and fluorine atoms in its structure enhances the biological activity of the final agrochemical products, particularly those aimed at controlling broadleaf weeds and certain insect species.

Its structural flexibility and reactivity make it an essential building block in the development of pre-emergent herbicides and pyrethroid-type insecticides. This compound is typically involved in the early steps of agrochemical synthesis, meaning that its quality directly affects the efficacy, environmental stability, and selectivity of the final crop protection agents.

Importance of CAS No. 114776-15-7 in Crop Protection

Herbicide Precursor:

This compound is commonly used in the synthesis of herbicides that act on weed germination processes, helping to protect crops like soybeans, maize, and wheat from early-stage weed competition.

Insecticide Intermediate:

Its functional groups are ideal for creating ester and ketone derivatives that are toxic to a variety of insect species, especially in the development of systemic insecticides used in fruit and vegetable farming.

Stability and Bioavailability:

The fluorine and chlorine atoms enhance environmental persistence and lipophilicity, which help active ingredients penetrate plant tissues and resist degradation from sunlight and water exposure.

Scalable and Cost-Efficient Production:

CAS 114776-15-7 is valued for its high yield in batch synthesis and relatively low production cost, making it suitable for large-scale agrochemical manufacturing.

Regulatory Compliance:

Manufacturers must meet REACH, EPA, and other regulatory standards to ensure the safe use of this intermediate in agriculture. Compliance with environmental safety and residue tolerance levels is critical.

Top 10 Manufacturers of CAS No. 114776-15-7

1. BASF

• Location: Ludwigshafen, Germany

• Overview: A pioneer in agricultural chemistry, BASF manufactures intermediates for a wide range of herbicides and insecticides. Their facilities produce CAS 114776-15-7 for integration into proprietary weed control products used globally.

• Specialty: Selective herbicide precursors and green synthesis processes.

2. FMC Corporation

• Location: Philadelphia, USA

• Overview: FMC is a global leader in crop protection solutions and agrochemical innovation. They manufacture intermediates like CAS 114776-15-7 for high-performance herbicides targeting resistant weed species.

• Specialty: Herbicide innovation, sustainable farming inputs.

3. Eastfine

• Location: Changzhou City, Jiangsu Province, China

• Overview: Eastfine is a trusted global supplier of agrochemical intermediates, offering consistent, high-quality production of CAS 114776-15-7. Known for its competitive pricing and adherence to international environmental and quality standards, Eastfine supports a global network of formulators and pesticide manufacturers.

• Specialty: Halogenated intermediates for herbicides and insecticides.

4. UPL Ltd.

• Location: Mumbai, India

• Overview: UPL produces a wide range of crop protection chemicals and is increasingly focused on backward integration through in-house intermediate production. CAS 114776-15-7 supports their herbicide formulations across cereals and oilseed crops.

• Specialty: Integrated agrochemical supply chains, post-patent chemistry.

5. ADEKA Corporation

• Location: Tokyo, Japan

• Overview: ADEKA has a long-standing presence in chemical manufacturing and produces specialized intermediates for agrochemical synthesis, including fluorinated and chlorinated building blocks like CAS 114776-15-7.

• Specialty: Fluoro-organic intermediates and pesticide additives.

6. Lianhetech Europe

• Location: Rotterdam, Netherlands

• Overview: While based in Europe, Lianhetech operates globally as a CDMO for both agrochemical and pharmaceutical intermediates. Their European site manufactures intermediates like CAS 114776-15-7 under REACH and EU regulations.

• Specialty: Custom synthesis, regulatory compliance, green chemistry.

7. Nufarm Limited

• Location: Melbourne, Australia

• Overview: Nufarm is an established player in the global agrochemical market. While primarily focused on formulation, they also produce essential intermediates, including halogenated esters used in selective herbicides.

• Specialty: Herbicide intermediates and off-patent actives.

8. Albaugh LLC

• Location: Ankeny, Iowa, USA

• Overview: Albaugh focuses on high-volume generic agrochemicals and their intermediates. Their North American and European plants are capable of producing intermediates like CAS 114776-15-7 at scale for use in their broad herbicide product line.

• Specialty: Cost-effective crop protection chemistry.

9. Isagro S.p.A. (Gowan Group)

• Location: Milan, Italy

• Overview: A research-driven agrochemical manufacturer, Isagro (now part of Gowan) focuses on sustainable solutions and innovative crop protection products. CAS 114776-15-7 is used in their research and commercial formulations.

• Specialty: Eco-friendly synthesis and EU-compliant manufacturing.

10. Coromandel International

• Location: Hyderabad, India

• Overview: Coromandel is one of India’s largest agri-input companies, producing fertilizers, insecticides, and herbicides. Their agrochemical business includes intermediate synthesis facilities for global distribution.

• Specialty: Integrated crop care solutions and fluorinated intermediates.

Trends in the Agrochemical Intermediates Market

Shift Toward Selective Herbicides:

With growing resistance to conventional herbicides, companies are investing in the development of selective weed control agents. Intermediates like CAS 114776-15-7 are central to these innovations.

Focus on Sustainability and Green Chemistry:

Environmental pressures and regulatory tightening are pushing agrochemical companies to adopt greener synthetic processes, reduce solvent use, and implement safer waste management.

Global Supply Chain Diversification:

After recent disruptions, many companies are diversifying their intermediate supply chains, increasing demand for reliable producers like Eastfine, ADEKA, and UPL.

Growth in Emerging Markets:

Increased food demand in Asia-Pacific, Latin America, and Africa is driving the expansion of agrochemical production and the need for scalable intermediate supply.

R&D for Patent Expiry Opportunities:

As major crop protection molecules go off-patent, intermediate manufacturers are competing to supply high-purity precursors to generics manufacturers worldwide.

Conclusion

CAS No. 114776-15-7 (Ethyl 2-chloro-4-fluorobenzoylacetate) plays a key role in the synthesis of next-generation herbicides and insecticides. Leading companies such as BASF, FMC, and Eastfine are ensuring high-quality, compliant, and scalable production of this critical intermediate.

As the world seeks more sustainable and effective agricultural solutions, demand for advanced intermediates like this one will continue to grow. Companies that innovate in manufacturing, maintain strict regulatory adherence, and deliver consistent quality will remain essential players in the global agrochemical supply chain.