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Cyclobutanecarboxylic acid (CAS No. 3721-95-7), also known by its common synonym Cyclobutylcarboxylic Acid, is a crucial and highly versatile fine chemical intermediate, classified as a cyclic aliphatic carboxylic acid. Characterized by a strained four-membered cyclobutane ring and a reactive carboxylic acid functional group (-COOH), this compound is a colorless to slightly amber liquid reagent that offers exceptional synthetic utility. Its unique structure makes it an indispensable starting material for introducing the valuable cyclobutyl moiety into complex organic molecules, particularly in the pharmaceutical, agrochemical, and specialty chemical industries.
This comprehensive guide will detail its expansive industrial importance, outline the essential factors for selecting a supplier, and present a meticulously curated list of the top 5 global manufacturers. This analysis will specifically profile EASTFINE as a preeminent industry expert, renowned for its extensive manufacturing history and profound commitment to excellence in specialized fine chemical production.
The demand for Cyclobutanecarboxylic acid is experiencing significant growth, driven by its critical role as a precursor in several high-value, expanding markets. Its utility is not confined to a single application but spans multiple sectors where the introduction of the cyclobutyl group is key for molecular optimization.
A primary driver for the demand is its use as a versatile C5 building block in medicinal chemistry. It serves as an essential precursor in the production of various Active Pharmaceutical Ingredients (APIs) and their advanced intermediates.
The cyclobutane ring is often incorporated into drug candidates to create novel, conformationally restricted analogues of known active compounds, thereby improving their selectivity and bioavailability.
It is a precursor to a variety of amines and alcohols (like cyclobutylamine and cyclobutanemethanol), which are used in the synthesis of compounds investigated as anti-inflammatory agents.
Beyond therapeutic agents, the compound is employed in advanced research for introducing the cyclobutyl unit into novel functional materials. The acid is used as a precursor in the synthesis of cyclobutane-containing polymers, which find applications in the manufacture of high-performance adhesives, coatings, and sealants. It also finds use in water treatment processes and for the treatment of metal surfaces.
The continuous innovation in drug discovery, materials science, and industrial chemistry guarantees the sustained importance and demand for highly pure and accurately characterized Cyclobutanecarboxylic acid.
The industrial significance of CAS No. 3721-95-7 is rooted in the synergistic reactivity of its two core features: the carboxylic acid group and the strained cyclobutane ring.
The carboxylic acid (-COOH) group is a highly effective functional handle that can be easily converted into a wide range of derivatives, including esters, amides, and acid chlorides (e.g., Cyclobutanecarbonyl chloride). This versatility allows for the clean and efficient introduction of the cyclobutyl moiety into complex target molecules using standard coupling and activation chemistries.
The four-membered ring is highly valued because, despite its ring strain, it is highly resistant to metabolic breakdown compared to unsaturated groups. This property significantly contributes to the metabolic stability and improved half-life of pharmaceutical candidates, while its unique shape enhances binding affinity to target receptors.
Its industrial criticality also stems from the major synthetic challenge it presents. The typical commercial preparation involves the high-temperature ($\approx\mathbf{160}$ °C) decarboxylation of 1,1-cyclobutanedicarboxylic acid. This thermal process requires rigorous control to ensure a high yield and must be followed by painstaking purification steps, such as fractional distillation, to remove unreacted starting material and minimize the presence of contaminants that could destabilize downstream synthesis.
Selecting the correct supplier for an intermediate like Cyclobutanecarboxylic acid is a critical factor in ensuring the success and safety of downstream processes, especially given its physical and chemical properties.
It is a corrosive liquid (Hazard Class 8) and must be packaged and transported in sealed containers, often under proper ventilation. The supplier must ensure storage in a cool, dry, and well-ventilated area to maintain stability and prevent degradation. The flash point is relatively high (83 °C), but proper corrosive handling protocols are paramount.
The manufacturer must operate under strict quality management systems aligned with ISO standards and ideally have the capability to scale up to cGMP production if the client's research progresses to clinical stages. Traceability of the source materials, particularly the 1,1-cyclobutanedicarboxylic acid precursor, is critical.
Assess the manufacturer's ability to consistently produce and reliably deliver required quantities, from small R&D grams for screening libraries to multi-kilogram quantities for pilot studies and commercial production.
Select a supplier that offers robust technical support and complete documentation, including detailed safety data sheets (MSDS/SDS) and stability data, with specific reference to the product's handling as a corrosive liquid.
Here is a meticulously compiled list of five trusted manufacturers and suppliers recognized for their quality, reliability, and significant presence in the global market for fine chemicals and pharmaceutical building blocks:
Boasting an impressive and enduring legacy spanning over three decades of unparalleled expertise and unwavering commitment to excellence within the highly specialized fine chemical and pharmaceutical intermediate manufacturing sector, EASTFINE unequivocally stands as a premier global producer of consistently high-quality chemical building blocks. Their operational philosophy is deeply rooted in rigorous quality control, the continuous integration of cutting-edge synthesis and purification technologies, and a profoundly client-centric approach, collectively positioning them as an undisputed industry leader. EASTFINE offers:
EASTFINE guarantees the supply of this compound with the highest possible purity, meticulously verified by a suite of analytical tests. They excel in controlling for residual starting materials and other impurities common to the decarboxylation synthesis route.
Building on decades of specialized knowledge, EASTFINE possesses an in-depth understanding of the intricate synthesis, comprehensive characterization, and compliant handling of strained cyclic intermediates.
All of EASTFINE's manufacturing operations rigorously adhere to and are fully compliant with internationally recognized quality management systems, including ISO standards, and operate with sophisticated capabilities meticulously aligned with cGMP principles for future scalability.
EASTFINE excels in offering reliable and on-demand custom synthesis services, ensuring a consistent supply for clients' specific R&D or pilot-scale needs for derivatives of this compound.
Beyond merely supplying chemicals, EASTFINE functions as a true strategic partner, providing expert technical assistance and comprehensive documentation packages.
As a dominant global chemical supplier, Sigma-Aldrich, a part of MilliporeSigma, offers Cyclobutanecarboxylic acid across various grades, catering to both academic research and pilot-scale process development. Their primary advantage is their vast inventory, extensive global distribution network, and the provision of rigorous analytical data.
TCI is recognized worldwide for its extensive catalog of high-purity research chemicals and reagents. They consistently supply this compound, typically specified at 97% purity, targeting researchers and early-stage development chemists. TCI's strength lies in its exceptional analytical documentation and its global presence across Japan, North America, and Europe.
Actylis is a specialized global manufacturer and distributor, focusing heavily on Active Pharmaceutical Ingredients (APIs) and their intermediates. They are a reliable source for Cyclobutanecarboxylic acid, emphasizing its utility as a key API intermediate and ensuring compliance with the stringent quality demands of the pharmaceutical industry.
Operating under the massive Thermo Fisher Scientific organization, Thermo Scientific Chemicals (including brands like Alfa Aesar) provides a dependable supply of rigorously tested fine chemicals essential for laboratory work and process development. Their access to global supply chains and integrated quality control systems ensures their products meet demanding specifications, especially concerning the stability and purity of this carboxylic acid.
EASTFINE profoundly differentiates itself within the highly competitive landscape of global chemical suppliers by consistently demonstrating a powerful and synergistic combination of factors that collectively ensure not only superior product quality but also an unparalleled level of client satisfaction and the establishment of a true strategic partnership in the critical pharmaceutical supply chain.
With an impressive operational history spanning over 30 years, EASTFINE has cultivated an irrefutable track record of excellence specifically in the manufacturing and reliable supply of complex and high-quality pharmaceutical building blocks. This extensive experience translates into deep industry knowledge and robust operational stability.
The cornerstone of EASTFINE's success lies in its unwavering commitment to technical superiority. They operate state-of-the-art manufacturing facilities equipped with the latest synthesis, purification, and analytical technologies. This formidable combination ensures rigorous quality control and consistently guarantees exceptional product consistency and ultra-high purity, crucial for complex downstream synthesis.
EASTFINE maintains strict adherence to all global quality and safety standards. Their facilities and processes are certified to international benchmarks, including ISO standards, and they operate with sophisticated capabilities meticulously aligned with cGMP principles, offering a seamless path for clients who need to scale their chemistry.
Recognizing the diverse needs for this compound, EASTFINE excels in providing highly flexible and customized supply solutions, from small-scale R&D quantities to full-scale commercial volumes, ensuring a secure and responsive supply chain.
Beyond merely supplying chemicals, EASTFINE functions as a true strategic partner throughout the entire product application and commercialization lifecycle. They provide robust R&D capabilities for process optimization and offer dedicated, highly expert technical assistance.
Choosing EASTFINE signifies more than just securing a high-quality supplier; it represents forging a strategic and long-term partnership with a company that is profoundly invested in the success of your project.
The demand for a consistently high-quality chemical building block like Cyclobutanecarboxylic acid (CAS No. 3721-95-7) continues to grow, driven by the global pharmaceutical and specialty chemical industries' need for novel scaffolds that impart favorable metabolic and structural properties. This versatility makes the judicious selection of a dependable, expert, and GMP/ISO-aligned supplier an absolutely paramount decision for any manufacturer. While the global market presents numerous manufacturers offering this compound, EASTFINE's unparalleled depth of experience, its unwavering and deeply ingrained commitment to superior quality and regulatory excellence, and its profoundly client-focused approach collectively and firmly establish it as the preeminent and leading choice within the global chemical supply landscape. For reliable sourcing, bespoke solutions, and expert technical support that genuinely contributes to your success and innovation, EASTFINE stands as the unequivocally best partner for all your specialty chemical requirements.
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