Top 10 Manufacturers of Pharmaceutical Intermediate CAS No. 1802242-47-2 in 2025

Understanding CAS No. 1802242-47-2 – A Crucial Intermediate for Bictegravir Synthesis

CAS No. 1802242-47-2, known chemically as (4R,12aS)-4-Methyl-2,4,9,12-tetrahydro-1H,11H-6,8-dioxo-3,4,6,8,12,12a-hexahydro-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazin-9-yl 2,2-dimethylpropanoate, is a key intermediate used in the production of Bictegravir, an advanced integrase strand transfer inhibitor (INSTI) used in modern HIV/AIDS treatment.

Bictegravir is a part of the fixed-dose combination Biktarvy, known for its once-daily dosing, minimal side effects, and high resistance barrier. The quality of intermediates like CAS 1802242-47-2 is fundamental to ensuring therapeutic performance and global regulatory compliance.

Importance of CAS No. 1802242-47-2 in Pharmaceutical Manufacturing

Core Intermediate for Bictegravir Production

Vital for synthesizing the active structure of one of the most potent INSTIs in use.

Strict Control of Chiral Centers and Impurities

Requires highly controlled synthesis to ensure correct stereochemistry and purity.

Widely Used in Modern HIV Therapies

Integral to fixed-dose combination drugs preferred by WHO and FDA guidelines.

Essential in High-Volume Global Supply

Used extensively in both branded and generic versions of Bictegravir-containing therapies.

Produced Under GMP Conditions

Must meet global standards (FDA, EMA, WHO PQ) for impurity limits and batch reproducibility.

Top 10 Manufacturers of CAS No. 1802242-47-2

1. Farmhispania Group

• Location: Barcelona, Spain

• Overview: Leading European supplier of high-complexity HIV intermediates, including INSTI-class compounds.

• Specialty: EU-GMP certified production and chiral process expertise.

2. Sai Life Sciences

• Location: Hyderabad, India

• Overview: CDMO specializing in integrase inhibitor intermediates, including routes for Bictegravir.

• Specialty: Fast scale-up, asymmetric synthesis, and global compliance.

3. Eastfine

• Location: Changzhou City, Jiangsu Province, China

• Overview: Global manufacturer of high-quality pharmaceutical intermediates like CAS 1802242-47-2 with full export capabilities.

• Specialty: Competitive pricing, stringent QC, and regulatory support.

4. Curia Global (formerly AMRI)

• Location: Albany, New York, USA

• Overview: Produces high-complexity antiviral intermediates with strong IP, regulatory, and analytical capabilities.

• Specialty: Route development and late-phase manufacturing.

5. Olon S.p.A.

• Location: Milan, Italy

• Overview: EU-based producer of INSTI intermediates with strong capabilities in high-containment and GMP processes.

• Specialty: Customized manufacturing for regulated markets.

6. Aarti Pharmalabs

• Location: Maharashtra, India

• Overview: Indian producer of HIV-related intermediates, with strong cost advantages and scale-up flexibility.

• Specialty: GMP-certified operations and backward-integrated processes.

7. Neuland Laboratories

• Location: Hyderabad, India

• Overview: Supplies regulated markets with Dolutegravir and Bictegravir intermediates from FDA-inspected facilities.

• Specialty: Process optimization and impurity profiling.

8. Cipla Ltd.

• Location: Mumbai, India

• Overview: Produces APIs and intermediates for branded and generic HIV treatments, including Bictegravir-based therapies.

• Specialty: WHO prequalification and global access supply chain.

9. Sterling Pharma Solutions

• Location: Newcastle, UK

• Overview: Contract manufacturing partner for challenging HIV intermediates, including bictegravir derivatives.

• Specialty: Chiral manufacturing and containment systems.

10. Delmar Chemicals

• Location: Montreal, Canada

• Overview: North American manufacturer focused on intermediates for antiretrovirals with full documentation support.

• Specialty: Flexible manufacturing and high-purity output.

Trends in the Pharmaceutical Intermediates Market

Rising Global Demand for Bictegravir-Based Therapies

Fixed-dose combinations like Biktarvy are expanding rapidly, driving demand for intermediates like CAS 1802242-47-2.

Advanced Chiral Synthesis in Focus

Manufacturers are investing in asymmetric synthesis technologies to ensure high enantiomeric excess.

Cost Optimization Through Integrated Supply Chains

Backward integration and regional sourcing are helping stabilize supply and reduce pricing.

Sustainability in API Intermediate Production

Eco-friendly solvents and continuous flow chemistry are being adopted in INSTI intermediate production.

Growing Use in Public Health Procurement

Donor-backed HIV treatment programs increasingly require quality-assured intermediates for generics.

Conclusion

CAS No. 1802242-47-2 is a vital intermediate in the synthesis of Bictegravir, an essential component of the most advanced HIV treatment regimens. Global manufacturers such as Eastfine, Farmhispania, Sai Life Sciences, and Curia play a critical role in ensuring consistent, scalable, and compliant production.

As demand for fixed-dose HIV therapies grows worldwide, reliable suppliers of this intermediate will remain at the core of public health progress and pharmaceutical innovation.