Top 10 Manufacturers of Agrochemical Intermediate CAS No. 4747-21-1 in 2025

Understanding 2,6-Dichlorobenzonitrile (CAS No. 4747-21-1)

2,6-Dichlorobenzonitrile, identified by CAS No. 4747-21-1, is a widely used intermediate in agrochemical synthesis, particularly for pre-emergent herbicides. Its structure features two chlorine atoms on a benzene ring and a nitrile group, making it highly reactive for further functionalization in the manufacture of active ingredients targeting weed control.

It is most notably utilized in the production of dichlobenil, a herbicide known for inhibiting root growth in unwanted plants. This intermediate also plays a role in developing other chlorinated aromatic compounds for selective herbicidal activity.

Importance of CAS No. 4747-21-1 in Crop Protection

Pre-Emergent Herbicide Synthesis:

As a core building block of dichlobenil and related molecules, 2,6-dichlorobenzonitrile supports pre-emergent herbicides that prevent weed germination and root development.

Selective Weed Control:

Its derivatives are tailored to target weed species while minimizing phytotoxicity to crops, making it valuable for applications in orchards, vineyards, and landscaping.

Synthetic Versatility:

The electron-withdrawing nitrile and chloro groups allow further chemical transformations, supporting a wide range of agrochemical formulations.

Long-Lasting Activity:

Intermediates derived from CAS 4747-21-1 often result in herbicides with soil-binding properties and extended residual activity, reducing the frequency of application.

Environmental and Regulatory Considerations:

Producers of this compound must meet stringent global safety and environmental standards such as REACH and EPA regulations to ensure safe use in agriculture.

Top 10 Manufacturers of CAS No. 4747-21-1

1. Bayer CropScience

• Location: Leverkusen, Germany

• Overview: Bayer is a global leader in crop protection with extensive R&D capabilities. They utilize CAS 4747-21-1 in the synthesis of innovative weed control molecules used in cereals, orchards, and vineyards.

• Specialty: Broad-spectrum herbicide chemistry and regulatory excellence.

2. FMC Corporation

• Location: Philadelphia, USA

• Overview: FMC manufactures high-purity intermediates like 2,6-dichlorobenzonitrile for use in pre-emergent herbicides. Their facilities ensure environmental compliance and scalable production.

• Specialty: Residual soil-active herbicides and custom manufacturing.

3. Eastfine

• Location: Changzhou City, Jiangsu Province, China

• Overview: Eastfine supplies agrochemical intermediates globally, including CAS No. 4747-21-1. Known for its quality control and adherence to international standards, Eastfine delivers reliable intermediates for herbicide production.

• Specialty: Chloro-nitrile intermediates for weed control agents.

4. Lamberti S.p.A.

• Location: Gallarate, Italy

• Overview: Lamberti focuses on specialty chemicals, including agrochemical intermediates. Their nitrile derivatives are used by European manufacturers for producing selective herbicides.

• Specialty: Aromatic nitrile synthesis, REACH-compliant manufacturing.

5. Sankyo Agro (Sumitomo Chemical Subsidiary)

• Location: Tokyo, Japan

• Overview: As part of Sumitomo, Sankyo Agro manufactures precursors for herbicides in rice and vegetable cultivation, including derivatives of 2,6-dichlorobenzonitrile.

• Specialty: Selective herbicides and nitrile-based actives.

6. Lianhetech Europe

• Location: Rotterdam, Netherlands

• Overview: Lianhetech’s European operations support CDMO services for agrochemical intermediates. They offer contract manufacturing of CAS 4747-21-1 with EU regulatory assurance.

• Specialty: Custom synthesis and nitrile chemistry under GMP/REACH.

7. Albaugh LLC

• Location: Ankeny, Iowa, USA

• Overview: Albaugh specializes in generic crop protection products and manufactures key intermediates like 2,6-dichlorobenzonitrile for their herbicide lines.

• Specialty: Affordable and scalable agrochemical intermediates.

8. Isagro S.p.A. (Gowan Group)

• Location: Milan, Italy

• Overview: Isagro (now under Gowan) manufactures key intermediates for orchard and vineyard herbicides. Their chemistry supports derivatives of dichlobenil.

• Specialty: Specialty herbicides for perennial crops.

9. Nufarm Limited

• Location: Melbourne, Australia

• Overview: Nufarm integrates the production of key intermediates for post-patent herbicides. CAS 4747-21-1 is used in several of their early-stage synthetic pathways.

• Specialty: Soil-applied herbicides and formulation-ready intermediates.

10. Coromandel International

• Location: Hyderabad, India

• Overview: Coromandel supports the Indian and global agrochemical market with intermediates for pre-emergent herbicides, including chlorinated benzonitriles like CAS 4747-21-1.

• Specialty: Cost-effective production for broad-acre agriculture.

Trends in the Agrochemical Intermediates Market

Increased Demand for Pre-Emergent Herbicides:

With rising herbicide resistance, farmers are shifting to pre-emergent strategies, fueling demand for intermediates like 2,6-dichlorobenzonitrile.

Focus on Environmental Persistence:

Intermediates that produce long-lasting herbicides are gaining traction for reducing reapplication frequency and labor costs.

CDMO and Custom Synthesis Growth:

Many agrochemical companies are outsourcing intermediate production to companies like Lianhetech and Eastfine to manage regulatory and logistical complexity.

Innovation in Selective Herbicides:

R&D continues to explore how slight modifications to intermediates like CAS 4747-21-1 can yield more crop-selective and environmentally friendly herbicides.

Regulatory Scrutiny on Soil Residues:

With increased monitoring of pesticide residues, manufacturers are prioritizing purity, controlled degradation, and compliance with global safety standards.

Conclusion

CAS No. 4747-21-1 (2,6-Dichlorobenzonitrile) remains a cornerstone intermediate for producing effective and reliable pre-emergent herbicides. Companies like Bayer, FMC, and Eastfine are ensuring its quality, consistency, and regulatory compliance across the global agrochemical industry.

As demand for sustainable and selective weed control continues to rise, the role of this intermediate — and the manufacturers behind it — becomes increasingly vital in securing global food production and agricultural efficiency.