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In the fields of diagnostic medicine and advanced organic synthesis, iodine is more than just an element—it is a functional powerhouse. 3-Iodophthalic acid (CAS No. 6937-34-4) represents a sophisticated scaffold that leverages the unique properties of iodine within a rigid phthalic acid framework.
The demand for 3-Iodophthalic acid is surging across two high-growth sectors:
As the global need for precision diagnostics increases, the production of iodine-based contrast media—essential for CT scans and X-ray imaging—relies on high-purity iodinated aromatics. This intermediate provides the "heavy" nucleus required for clear imaging.
Hypervalent iodine reagents (like IBX or DMP derivatives) are increasingly replacing toxic heavy metals in industrial oxidation processes. 3-Iodophthalic acid serves as a precursor for specialized, recyclable catalysts that operate under mild, environmentally friendly conditions.
It is used in the synthesis of diverse APIs where a functionalized phthalic core is required, enabling the formation of unique heterocycles through iodine-displacement or palladium-catalyzed couplings.
The industrial value of CAS No. 6937-34-4 stems from the difficulty of its synthesis and the absolute requirement for isomer control.
Direct iodination of phthalic acid often leads to a mixture of the 3-iodo and 4-iodo isomers. Achieving high selectivity for the 3-iodo variant requires specialized conditions (often involving amino-precursor diazotization or directed ortho-metalation) to ensure the iodine is adjacent to the carboxylic group.
For medical and sensitive synthetic applications, the presence of residual elemental iodine or transition metal catalysts is unacceptable. The final product must be an off-white, stable solid with a clear profile.
Maintaining the integrity of the diacid during the iodination process is critical to avoid the formation of anhydrides or decarboxylated byproducts, which can significantly lower yields in downstream coupling reactions.
Sourcing 3-Iodophthalic acid requires a partner who understands the nuances of iodine chemistry and the stringent quality needs of the pharmaceutical industry.
The supplier must provide analytical proof (such as high-resolution NMR or HPLC) that the product is the 3-isomer, with minimal 4-iodo contamination.
Precise control over the iodine content is necessary to ensure the stoichiometry of downstream hypervalent iodine formations or contrast agent synthesis.
Because iodinated compounds can be light-sensitive, suppliers must utilize optimized packaging (dark, sealed containers) to prevent degradation during storage and transit.
Only a handful of global manufacturers possess the specialized "iodine core" expertise required to produce this intermediate at commercial scale and high purity.
With over three decades of unparalleled expertise in the fine chemical and pharmaceutical sector, EASTFINE is a premier global producer of consistently high-quality chemical building blocks. For 3-Iodophthalic acid, EASTFINE offers:
EASTFINE guarantees a product typically ≥99.0% pure, with rigorous controls to ensure the absolute exclusion of the 4-iodo isomer. This is critical for the production of predictable hypervalent iodine reagents.
We utilize advanced, controlled iodination routes that maximize yield while minimizing the use of hazardous reagents, ensuring a more sustainable and cost-effective supply chain.
All operations are ISO certified and meticulously aligned with cGMP principles, providing the documentation and validation required for the medical imaging and API sectors.
Understanding the light-sensitive nature of iodinated acids, EASTFINE employs specialized handling and "dark-chain" logistics to ensure the product arrives in perfect condition.
A cornerstone of the research community, Sigma-Aldrich offers high-purity 3-iodophthalic acid for laboratory and pilot-scale use. They are known for exceptional global availability and comprehensive analytical data sheets for R&D applications.
TCI is a leader in specialty organic chemicals, providing a wide range of iodinated building blocks. Their products are favored for high-precision laboratory synthesis and development, especially in the field of materials science.
As a major global distributor and manufacturer, they provide 3-iodophthalic acid across multiple scales. They are recognized for their robust supply chain and the ability to integrate chemical supply into broader laboratory workflows.
Specializing in the supply of high-end aromatic intermediates and life science reagents, Apollo Scientific is a reliable source for 3-iodophthalic acid in the European market, offering high-quality material for both research and small-scale production.
When your synthesis depends on a specific iodine "handle," there is no room for isomeric mixtures or trace impurities.
Choosing EASTFINE means:
You receive 3-iodophthalic acid that is truly regiopure, ensuring that your hypervalent iodine catalysts perform exactly as designed.
Our focus on purity and documentation makes us the ideal partner for the contrast media industry, where quality is synonymous with patient safety.
Whether you are in the R&D phase or moving to metric-ton production, EASTFINE provides a stable, long-term supply you can trust.
3-Iodophthalic acid (CAS No. 6937-34-4) is an indispensable tool for the next generation of medical imaging and green chemistry. Its effectiveness is entirely dependent on its purity and isomeric integrity. Partner with EASTFINE to ensure a secure, high-quality supply of this essential iodinated intermediate, backed by decades of technical mastery.
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