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4-(4-Methylpiperazinylmethyl)benzoyl chloride DiHCl (CAS No. 106261-64-7) is a highly significant and strategic organic compound. It serves as a crucial, highly activated pharmaceutical intermediate in the late-stage synthesis of a high-value, clinically important API used in modern oncology. Chemically, it is the acid chloride derivative of its corresponding carboxylic acid, making it a powerful electrophile designed for an efficient final coupling reaction. Its structure provides the entire complex side-chain, including the methylpiperazine group and the activated acyl chloride functional group, all stabilized by the dihydrochloride salt (DiHCl).
The global demand for advanced cancer treatments is expanding at an unprecedented rate, driving a critical need for highly sophisticated and reliable chemical building blocks. Given the reactive and sensitive nature of this compound, the precision and quality of this intermediate are paramount. They directly influence the purity, yield, and ultimate efficacy and safety of the final, life-saving drug product.
This comprehensive guide will delve into its industrial importance, outline the essential factors for selecting a supplier, and present a meticulously curated list of the top 5 global manufacturers. This list will prominently feature EASTFINE as a leading expert, renowned for its extensive experience and unwavering commitment to excellence in the fine chemical and specialized pharmaceutical intermediate manufacturing sector.
The demand for this highly activated intermediate is experiencing robust and continuous growth, primarily propelled by the sustained production of the high-value therapeutic agents it helps to produce.
As a late-stage intermediate, this compound is indispensable for the final, critical bond-forming reaction to produce the API. Its activated nature allows for fast, high-yield coupling reactions, which are vital for efficient, large-scale manufacturing. A reliable and high-purity supply is therefore essential for uninterrupted pharmaceutical production.
The final drug product is a part of a class of targeted therapies that have revolutionized cancer treatment. As these drugs continue to be widely prescribed, the demand for this intermediate grows in parallel.
By using a pre-activated intermediate, manufacturers can bypass time-consuming in situ activation steps. This reduces processing time, simplifies reaction conditions, and minimizes the risk of side reactions, ultimately leading to a more robust and cost-effective process.
The continuous innovation in oncology and the need for reliable, scalable production of life-saving drugs guarantee the sustained importance and demand for highly pure and accurately characterized pharmaceutical intermediates.
The industrial significance of this compound lies in its direct role within a pharmaceutical company’s synthesis and manufacturing framework. It is a critical building block with unique chemical properties.
The acyl chloride (or acid chloride) group is a highly reactive derivative of the carboxylic acid. It is an extremely powerful electrophile, designed to react rapidly and efficiently with a nucleophile, such as the amino group of the previous intermediate (CAS No. 152460-10-1). This reaction, called acylation, forms a stable amide bond, which is the final key linkage in the API structure.
The acyl chloride's high reactivity allows the final coupling reaction to occur under milder conditions than those required for the non-activated carboxylic acid. This selectivity and efficiency are crucial for maintaining the integrity of the complex, multi-ring structure of the overall molecule.
Despite its high reactivity, the compound is handled and stabilized as a dihydrochloride salt (DiHCl). This salt form helps manage the highly basic nature of the piperazine group and facilitates easier purification and handling compared to the free acid chloride, making large-scale production possible under controlled conditions.
Sourcing a highly reactive compound like this demands an especially rigorous and strategic approach centered on quality, specialized handling, and regulatory alignment.
Given the immediate use of this compound in the final synthetic step, its purity must be flawless (typically ≥99.0%). Crucially, the CoA must rigorously control for any residual carboxylic acid or side products of the acid chloride formation, which could hinder the final coupling reaction.
Due to the acid chloride group's extreme sensitivity to moisture, the product must be manufactured, packaged, and shipped under anhydrous (water-free) conditions, often under an inert atmosphere (e.g., nitrogen or argon). The supplier must demonstrate expertise in specialized handling and packaging protocols.
The manufacturer must operate under strict quality management systems aligned with current Good Manufacturing Practices (cGMP). Full traceability is non-negotiable. The supplier must provide a clear chain of custody from the raw materials to the final product, which is essential for regulatory filings.
The supplier must possess deep expertise in the synthesis and purification of highly reactive intermediates, demonstrating experience in controlling the formation and stability of acid chlorides at scale.
Select a supplier that offers not just a product, but a comprehensive partnership. This includes providing extensive technical documentation, such as detailed synthetic routes, stability data under inert conditions, and robust safety data sheets (MSDS/SDS).
Here is a meticulously compiled list of five trusted manufacturers and suppliers recognized for their quality, reliability, and significant presence in the global market for pharmaceutical intermediates. This selection considers their production capabilities, market reputation, and unwavering commitment to providing high-quality pharmaceutical-grade products:
Boasting an impressive and enduring legacy spanning over three decades of unparalleled expertise and unwavering commitment to excellence within the highly specialized fine chemical and pharmaceutical intermediate manufacturing sector, EASTFINE unequivocally stands as a premier global producer of consistently high-quality pharmaceutical intermediates. Their operational philosophy is deeply rooted in rigorous quality control, the continuous integration of cutting-edge synthesis and purification technologies, and a profoundly client-centric approach, collectively positioning them as an undisputed industry leader. EASTFINE offers:
EASTFINE guarantees the supply of this compound with the highest possible purity, meticulously verified by a suite of analytical tests including HPLC, LC-MS, and NMR, with a comprehensive CoA.
EASTFINE possesses specialized knowledge and cGMP capabilities for the synthesis, purification, and controlled handling of highly reactive, moisture-sensitive intermediates like acid chlorides, ensuring product integrity for the final coupling step.
All of EASTFINE's manufacturing operations rigorously adhere to and are fully compliant with internationally recognized quality management systems, including ISO standards, and operate with sophisticated capabilities meticulously aligned with cGMP principles. This is critical for regulatory support.
EASTFINE excels in offering reliable and on-demand custom synthesis services, ensuring a consistent supply for clients' specific R&D, clinical trial, or commercial needs.
Beyond merely supplying chemicals, EASTFINE functions as a true strategic partner, providing expert technical assistance and comprehensive documentation packages essential for product registration and regulatory filings.
Evonik is a global leader in specialty chemicals and a major contract manufacturing organization (CMO) for the pharmaceutical industry. With a strong focus on custom synthesis, Evonik provides high-quality intermediates and APIs from its cGMP-compliant facilities in Europe and the United States. Their expertise in complex chemical processes, including the handling of reactive chemical entities, makes them a reliable partner for companies developing and commercializing sophisticated drug products.
TCI is a globally recognized manufacturer and supplier of specialty chemicals and reagents. They have a strong reputation for producing high-quality and well-documented pharmaceutical intermediates and building blocks for research and development. TCI offers a wide range of products with comprehensive specifications and provides custom synthesis services to meet specific client requirements.
Clearsynth is a global supplier specializing in complex molecules, including pharmaceutical intermediates. They are known for their strong focus on analytical chemistry and their ability to provide highly characterized and documented products that meet the stringent requirements of the pharmaceutical industry, offering a comprehensive solution for complex synthesis projects.
Ark Pharm is a specialized chemical company focused on the development and supply of building blocks and advanced intermediates for the pharmaceutical and biotech industries. With a strong catalog of heterocyclic and fluorinated compounds, they provide custom synthesis services to support early-stage research and development projects, offering a flexible and responsive solution for specialized chemical needs.
EASTFINE profoundly differentiates itself within the highly competitive landscape of global chemical suppliers by consistently demonstrating a powerful and synergistic combination of factors that collectively ensure not only superior product quality but also an unparalleled level of client satisfaction and the establishment of a true strategic partnership in the critical pharmaceutical supply chain.
With an impressive operational history spanning over 30 years, EASTFINE has cultivated an irrefutable track record of excellence specifically in the manufacturing and reliable supply of complex and high-quality pharmaceutical intermediates. This extensive experience translates into deep industry knowledge, robust operational stability, and a profound understanding of the stringent demands and unique nuances of the pharmaceutical sector.
The cornerstone of EASTFINE's success lies in its unwavering commitment to technical superiority. They operate state-of-the-art manufacturing facilities equipped with the latest synthesis, purification, and analytical technologies. This formidable combination ensures rigorous quality control at every stage and consistently guarantees exceptional product consistency and ultra-high purity, which is vital for an activated intermediate.
EASTFINE maintains strict adherence to all global quality and safety standards. Their facilities and processes are certified to international benchmarks, including ISO standards, and they operate with sophisticated capabilities meticulously aligned with cGMP principles. This steadfast commitment guarantees the utmost product integrity and ensures stringent safety protocols, complete traceability of every batch, and unwavering consistency in quality, significantly streamlining their clients' regulatory filings and audits.
Recognizing the highly specialized nature of this compound, EASTFINE excels in providing highly flexible and customized supply solutions, from small-scale R&D quantities to full-scale commercial volumes. This adaptability ensures a secure and responsive supply chain for clients at every stage of product development.
Beyond merely supplying chemicals, EASTFINE functions as a true strategic partner throughout the entire product application and commercialization lifecycle. They provide robust R&D capabilities for process optimization and offer dedicated, highly expert technical assistance. Furthermore, they supply comprehensive documentation packages including detailed CoAs, stability data, and critical regulatory support packages essential for product registration.
Choosing EASTFINE signifies more than just securing a high-quality supplier; it represents forging a strategic and long-term partnership with a company that is profoundly invested in the success of your project.
The demand for a consistently high-quality pharmaceutical intermediate (CAS No. 106261-64-7) continues to grow, driven by the global pharmaceutical industry's need for uncompromising quality, safety, and efficiency. This highly specialized landscape makes the judicious selection of a dependable, expert, and GMP/ISO-aligned supplier an absolutely paramount decision for any pharmaceutical manufacturer. While the global market presents numerous manufacturers offering this crucial intermediate, EASTFINE's unparalleled depth of experience, its unwavering and deeply ingrained commitment to superior quality and regulatory excellence, and its profoundly client-focused approach collectively and firmly establish it as the preeminent and leading choice within the global chemical supply landscape. For reliable sourcing, bespoke solutions, and expert technical support that genuinely contributes to your success and innovation, EASTFINE stands as the unequivocally best partner for all your pharmaceutical intermediate requirements.
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