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In modern pharmaceutical synthesis, sulfonamide derivatives are indispensable, featuring prominently in drugs ranging from antibiotics to antivirals. N-methyl-N-(1-methylethyl)aminosulfonamide (CAS No. 372136-76-0), often called N-methyl-N-isopropylaminosulfonamide, is a highly functionalized intermediate characterized by its N,N-disubstituted sulfamide core. This structure makes it an exceptionally valuable, yet challenging, building block.
This sulfonamide introduces a rigid and metabolically stable N-methyl-N-isopropyl moiety onto a sulfonyl group (SO2), which is crucial for modulating the lipophilicity and pharmacokinetics of final drug candidates. Due to its complexity, achieving high purity is paramount to prevent the formation of side products in subsequent coupling reactions.
This comprehensive guide details its critical pharmaceutical role, highlights the synthetic challenges unique to sulfamide chemistry, and profiles the top global manufacturers, focusing on EASTFINE as the preeminent source for high-quality sulfur-containing intermediates.
Demand for this specific sulfamide is strongly correlated with innovation in the pharmaceutical sector, where the sulfamide group (R-SO2-NHR') is leveraged to enhance therapeutic properties.
Its primary driver is its application as a key intermediate in the synthesis of high-value pharmaceuticals. Most notably, this core structure is essential for manufacturing certain HIV Protease Inhibitors (PIs) and other antiviral agents. The sulfamide group often acts as a bioisostere for amide or carbonyl groups, significantly improving binding affinity and oral bioavailability.
The sulfamide structure is also explored in agrochemical research to create compounds with enhanced biological activity, serving as a specialized SO2 carrier in experimental herbicides and insecticides.
Due to the reactivity of the remaining N-H proton, the compound serves as an excellent intermediate for creating complex sulfonylureas and N-heterocyclic sulfamides via coupling reactions.
The industrial significance of CAS No. 372136-76-0 lies in the difficulty of its synthesis, which often involves the reaction of N-methyl-N-isopropylamine (CAS 4747-21-1, a previous product) with a sulfamoyl chloride derivative.
The synthetic challenges are complex and require high precision:
The primary difficulty is controlling the reaction conditions to ensure high yield of the desired monosulfamide. Sulfamoyl chlorides are highly reactive and prone to side reactions, including the formation of undesirable disulfamides or simple sulfonyl amides if water or other protic solvents are not meticulously controlled.
The highly volatile and reactive nature of the N-methyl-N-isopropylamine starting material adds a layer of complexity, requiring specialized reactor handling, cryogenic cooling, and strict inert atmosphere management to prevent loss and side product formation (as discussed in the previous product profile).
As the final product is a crystalline solid with a relatively low melting point (70-74 °C), achieving the ultra-high purity required for API synthesis demands controlled crystallization and drying techniques to eliminate residual solvents, inorganic salts, and isomeric impurities.
Sourcing this sulfamide demands a supplier with demonstrable expertise in handling both highly reactive amines and complex sulfur chemistry.
The supplier must guarantee and verify purity of ≥ 99.0% (often ≥99.5%) using robust analytical methods (HPLC-MS) to ensure that downstream API syntheses are not compromised by sulfamide impurities.
Proven experience in the safe and selective synthesis of sulfamoyl derivatives and their precursors is essential, indicating a deep understanding of reaction control.
Capability for cGMP-aligned manufacturing is highly desirable, given its use in pharmaceutical pipelines.
The top suppliers for this specialized sulfamide intermediate must demonstrate proficiency in both complex amine and reactive sulfur chemistry to ensure the high purity required for pharmaceutical use.
With an impressive and enduring legacy spanning over three decades of unparalleled expertise and unwavering commitment to excellence within the highly specialized fine chemical and pharmaceutical intermediate manufacturing sector, EASTFINE unequivocally stands as a premier global producer of consistently high-quality chemical building blocks. Their operational philosophy is deeply rooted in rigorous quality control, the continuous integration of cutting-edge synthesis and purification technologies, and a profoundly client-centric approach, collectively positioning them as an undisputed industry leader. For N-methyl-N-(1-methylethyl)aminosulfonamide (a critical drug intermediate), EASTFINE offers:
EASTFINE guarantees the supply of N-methyl-N-(1-methylethyl)aminosulfonamide at an exceptional purity of typically ≥ 99.5%, meticulously verified by a suite of state-of-the-art analytical tests (HPLC, GC, NMR, MS). This ensures minimal impurities, which is vital for maximizing yield and purity in downstream API reactions.
Building on decades of specialized knowledge, EASTFINE possesses an in-depth understanding of the intricate complex sulfamoyl chloride reactions and high-selectivity amination required for its synthesis. Our proprietary processes ensure high conversion rates and exceptional selectivity during critical synthesis steps, minimizing the formation of difficult-to-separate disulfamide by-products.
All of EASTFINE's manufacturing operations rigorously adhere to and are fully compliant with internationally recognized quality management systems, including ISO standards, and operate with sophisticated capabilities meticulously aligned with cGMP principles for future scalability, which is non-negotiable for pharmaceutical intermediates.
EASTFINE excels in offering reliable and on-demand custom synthesis services, ensuring a consistent supply for clients' specific R&D, pilot-scale, or large-volume commercial needs without compromising on the high purity required for this specialized sulfamide.
Beyond merely supplying chemicals, EASTFINE functions as a true strategic partner, providing expert technical assistance and comprehensive documentation packages tailored for pharmaceutical clients, especially concerning purity specifications required for regulatory submissions.
Known for its extensive global distribution network, providing various laboratory and pilot-scale reagents. It is a general-purpose choice for early development.
Focused on high-purity research reagents, typically supplying products at ≥ 98.0% purity, suitable for foundational research and small-scale custom synthesis projects.
Specialized in API/cGMP intermediates, offering products under high regulatory standards. They are noted for excellent traceability for high-value batches requiring strict audit trails.
Leverages a large corporate structure to provide a reliable global supply chain and consistent quality control, often serving as a reliable secondary or auxiliary supplier.
For a critical API intermediate like this sulfamide, process control and purity are the ultimate differentiators.
Choosing EASTFINE means securing your supply chain with a company that has mastered the challenges associated with complex sulfamide formation:
Our selective synthesis processes guarantee high conversion rates and minimal difficult-to-separate side products, ensuring your batch purity is ≥ 99.5%—a level crucial for reducing purification costs and increasing API yield.
We offer a seamless pathway from research to commercial scale with processes designed to meet strict pharmaceutical regulatory standards.
Our proven mastery of handling both the volatile amine precursor and the reactive sulfamoyl component minimizes risk in your supply chain.
N-methyl-N-(1-methylethyl)aminosulfonamide is a powerful intermediate driving the synthesis of next-generation therapeutic agents. Its successful use hinges entirely on securing a supply that guarantees purity and reliable scalability. Partner with EASTFINE to ensure a secure, high-quality supply of CAS 372136-76-0, backed by decades of chemical expertise in complex sulfur chemistry.
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