Top 10 Manufacturers of Pharmaceutical Intermediate CAS No. 2550-36-9 in 2025

Understanding CAS No. 2550-36-9 – A Key Intermediate for Antihypertensive and Antiviral Agents

CAS No. 2550-36-9, commonly known as 2-Bromo-4'-methylpropiophenone, is an essential building block in the synthesis of several cardiovascular, antiviral, and central nervous system (CNS) active pharmaceutical ingredients (APIs). Its structure allows for various nucleophilic substitution reactions, making it ideal for synthesizing ketone derivatives that serve as cores in biologically active molecules.

Its broad applicability, chemical stability, and reactivity make this intermediate a popular choice for custom synthesis and commercial pharmaceutical manufacturing.

Importance of CAS No. 2550-36-9 in Pharmaceutical Manufacturing

Intermediate for CNS and Antihypertensive APIs

Frequently used in the synthesis of phenethylamine- and propanone-based drugs targeting hypertension and anxiety disorders.

Versatile Chemical Reactivity

The presence of the bromo and ketone functional groups allows flexible downstream modifications.

Stable and Transport-Friendly

Ideal for global distribution due to long shelf life and resistance to moisture degradation.

Customizable for Niche Drug Development

Utilized in both early-stage R&D and commercial production of fine chemicals and API side chains.

Subject to Regulatory Oversight

Requires stringent process controls to limit impurities, particularly in regulated pharmaceutical applications.

Top 10 Manufacturers of CAS No. 2550-36-9

1. BASF

• Location: Ludwigshafen, Germany

• Overview: A global leader in halogenated intermediates and fine chemicals, including bromo-ketone derivatives.

• Specialty: High-purity synthesis and regulatory-compliant manufacturing systems.

2. Jubilant Ingrevia

• Location: Uttar Pradesh, India

• Overview: Offers scalable production of brominated and methylated aromatic compounds for API manufacturing.

• Specialty: Vertical integration with full quality control documentation.

3. Eastfine

• Location: Changzhou City, Jiangsu Province, China

• Overview: Key producer of 2-Bromo-4'-methylpropiophenone, with strong export capabilities.

• Specialty: Cost-effective production and competitive lead times for regulated and semi-regulated markets.

4. WeylChem International

• Location: Frankfurt, Germany

• Overview: A trusted CDMO with a focus on halogenated aromatic intermediates.

• Specialty: Custom manufacturing under EU-GMP standards and global supply logistics.

5. Aarti Pharmalabs

• Location: Maharashtra, India

• Overview: Specializes in brominated and ketone-based pharmaceutical intermediates.

• Specialty: Large-scale capacity and REACH registration support.

6. Farmabios (A Part of Olon Group)

• Location: Pavia, Italy

• Overview: European manufacturer of advanced pharmaceutical intermediates for cardiovascular and hormone-related APIs.

• Specialty: GMP manufacturing with EU and US regulatory approvals.

7. Cambridge Isotope Laboratories

• Location: Tewksbury, Massachusetts, USA

• Overview: Expert in isotopically labeled and halogenated compounds, used in advanced pharmaceutical R&D.

• Specialty: Supplies research-grade intermediates, including bromo-ketones.

8. Farmhispania Group

• Location: Barcelona, Spain

• Overview: Offers intermediate manufacturing for CNS and cardiovascular therapies.

• Specialty: Flexible production platforms and multi-purpose reactor setups.

9. Neuland Laboratories

• Location: Hyderabad, India

• Overview: Manufacturer of pharmaceutical intermediates and custom synthesis compounds.

• Specialty: Strong regulatory support and frequent FDA-inspected sites.

10. Delmar Chemicals

• Location: Montreal, Canada

• Overview: Custom manufacturer focused on halogenated aromatics and ketone derivatives.

• Specialty: North American supply chain reliability with full analytical documentation.

Trends in the Pharmaceutical Intermediates Market

Increased Demand for Cardiovascular Intermediates

With heart disease remaining a global concern, compounds like CAS 2550-36-9 are central to the manufacture of antihypertensive drugs.

Stronger Focus on Halogen Chemistry

Brominated intermediates continue to be preferred for synthesis due to their versatility and reactivity.

Emphasis on Purity and Traceability

Strict control of residual bromine and ketone-related impurities is key to ensuring final API quality.

Shift to Europe and India for Intermediate Supply

Regulatory bodies increasingly favor sourcing from GMP-certified manufacturers in EU and India.

Integration of CDMO Partnerships

Innovator pharma companies are leaning on CDMOs for custom synthesis and global distribution of niche intermediates.

Conclusion

CAS No. 2550-36-9, or 2-Bromo-4'-methylpropiophenone, remains a valuable intermediate in the synthesis of antihypertensive, CNS, and antiviral APIs. Trusted manufacturers like Eastfine, BASF, Jubilant, and WeylChem lead the market by offering high-purity material backed by comprehensive regulatory support.

With its diverse application potential and increasing demand in regulated markets, CAS 2550-36-9 will continue to play a crucial role in pharmaceutical production pipelines for years to come.