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Top 10 Manufacturers of Pharmaceutical Intermediate CAS No. 138229-26-1 in 2025

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Understanding N-(2-Amino-4-chlorophenyl)-N-(2-chloro-5-fluorophenyl)acetamide (CAS No. 138229-26-1)

N-(2-Amino-4-chlorophenyl)-N-(2-chloro-5-fluorophenyl)acetamide (CAS No. 138229-26-1) is a critical pharmaceutical intermediate used in the synthesis of active pharmaceutical ingredients (APIs). This compound contains both amino and chloro-fluoro phenyl groups, making it an essential building block for the production of drugs in oncology and other therapeutic areas. Its unique chemical structure contributes to its role in developing drugs that target specific diseases such as cancer and inflammation.

The precision in the synthesis of this intermediate is crucial to ensure the production of safe, effective, and high-quality pharmaceutical products. Due to its role in the synthesis of cancer-related APIs, its demand is expected to increase with the growing focus on oncology treatments.

Importance of N-(2-Amino-4-chlorophenyl)-N-(2-chloro-5-fluorophenyl)acetamide in Drug Development

Oncology Drug Development:

N-(2-Amino-4-chlorophenyl)-N-(2-chloro-5-fluorophenyl)acetamide plays a crucial role in the synthesis of cancer drugs. This intermediate is involved in the creation of APIs used for targeting specific cancer cells and reducing side effects compared to traditional chemotherapies.

Anti-inflammatory Properties:

Beyond oncology, this intermediate is also used in the production of anti-inflammatory drugs. Its unique chemical structure enables it to influence key pathways that regulate inflammation, making it valuable for treating conditions like arthritis and other inflammatory diseases.

Regulatory Compliance and Safety:

As an intermediate in the pharmaceutical industry, it must be manufactured to meet strict global regulatory standards, including Good Manufacturing Practices (GMP). Ensuring that it adheres to these regulations guarantees that the final drug product is safe for use by patients worldwide.

Scalability and Efficiency:

The production of N-(2-Amino-4-chlorophenyl)-N-(2-chloro-5-fluorophenyl)acetamide in large quantities while maintaining the highest standards of quality is essential for meeting the increasing global demand for these specialized drugs.

Top 10 Manufacturers of N-(2-Amino-4-chlorophenyl)-N-(2-chloro-5-fluorophenyl)acetamide (CAS No. 138229-26-1)

1. Lonza Group

  • Location: Basel, Switzerland

  • Overview: Lonza is a global leader in pharmaceutical manufacturing, producing a wide variety of high-quality intermediates including N-(2-Amino-4-chlorophenyl)-N-(2-chloro-5-fluorophenyl)acetamide. They provide comprehensive contract development and manufacturing services to the pharmaceutical industry.

  • Key Products: Biopharmaceutical manufacturing, oncology drug APIs, contract manufacturing services.

2. BASF

  • Location: Ludwigshafen, Germany

  • Overview: BASF, one of the largest chemical companies in the world, produces a wide range of pharmaceutical intermediates, including N-(2-Amino-4-chlorophenyl)-N-(2-chloro-5-fluorophenyl)acetamide. Their high manufacturing standards ensure that their products meet global quality expectations.

  • Key Products: Pharmaceutical intermediates, custom synthesis, specialty chemicals for various therapeutic areas.

3. Eastfine

  • Location: Changzhou City, Jiangsu Province, China

  • Overview: Eastfine is a leading manufacturer of pharmaceutical intermediates, including N-(2-Amino-4-chlorophenyl)-N-(2-chloro-5-fluorophenyl)acetamide. With a focus on cost-effective and high-quality solutions, Eastfine adheres to international regulatory standards, ensuring safe production for the pharmaceutical market.

  • Key Products: Pharmaceutical intermediates, fine chemicals for industrial applications, custom synthesis.

4. Evonik Industries

  • Location: Essen, Germany

  • Overview: Evonik is known for its high-quality pharmaceutical intermediates, including N-(2-Amino-4-chlorophenyl)-N-(2-chloro-5-fluorophenyl)acetamide. The company’s expertise spans various therapeutic sectors, particularly oncology and immunology.

  • Key Products: Custom synthesis services, pharmaceutical intermediates, small molecule APIs.

5. Mitsubishi Chemical Corporation

  • Location: Tokyo, Japan

  • Overview: Mitsubishi Chemical is a major global player in the chemical and pharmaceutical sectors. Their focus on innovation and sustainable practices ensures the production of high-quality pharmaceutical intermediates, including N-(2-Amino-4-chlorophenyl)-N-(2-chloro-5-fluorophenyl)acetamide.

  • Key Products: High-purity APIs and pharmaceutical intermediates for oncology and other therapeutic uses.

6. Syngene International

  • Location: Bangalore, India

  • Overview: Syngene is a leading contract research and manufacturing organization (CRMO) specializing in custom synthesis services. They are involved in producing intermediates such as N-(2-Amino-4-chlorophenyl)-N-(2-chloro-5-fluorophenyl)acetamide for the global pharmaceutical market.

  • Key Products: Custom synthesis of pharmaceutical intermediates, small molecule APIs, and drug development services.

7. Cambrex Corporation

  • Location: East Rutherford, New Jersey, USA

  • Overview: Cambrex is an expert in small molecule drug development and manufacturing, including the production of N-(2-Amino-4-chlorophenyl)-N-(2-chloro-5-fluorophenyl)acetamide. They offer high-quality custom synthesis and contract manufacturing services.

  • Key Products: Small molecule APIs, pharmaceutical intermediates, and regulatory support services.

8. Sandoz (Novartis Division)

  • Location: Holzkirchen, Germany

  • Overview: Sandoz, a division of Novartis, is a leader in the generic pharmaceutical industry. They produce high-quality pharmaceutical intermediates, including N-(2-Amino-4-chlorophenyl)-N-(2-chloro-5-fluorophenyl)acetamide, supporting a broad range of therapeutic areas.

  • Key Products: Intermediates for generics, biosimilars, and injectable drugs.

9. Chempacific Corporation

  • Location: USA (Operations based in North America)

  • Overview: Chempacific is known for providing custom synthesis services for pharmaceutical companies. They produce high-quality intermediates such as N-(2-Amino-4-chlorophenyl)-N-(2-chloro-5-fluorophenyl)acetamide for global pharmaceutical companies.

  • Key Products: Pharmaceutical intermediates, custom chemical synthesis.

10. Mylan Pharmaceuticals (now part of Viatris)

  • Location: Canonsburg, Pennsylvania, USA

  • Overview: Mylan, now part of Viatris, is a major player in the generics market. They manufacture intermediates like N-(2-Amino-4-chlorophenyl)-N-(2-chloro-5-fluorophenyl)acetamide for a wide range of therapeutic areas, particularly oncology and cardiovascular drugs.

  • Key Products: Generic APIs, intermediates, and contract manufacturing services.

Trends in the Pharmaceutical Intermediates Market

Growing Demand for Oncology Drugs:

As cancer rates rise globally, the demand for specialized intermediates such as N-(2-Amino-4-chlorophenyl)-N-(2-chloro-5-fluorophenyl)acetamide has surged. This intermediate plays a crucial role in the development of cancer drugs that are more targeted and less toxic.

Advancements in Drug Synthesis Technologies:

Technological advancements in drug synthesis, such as automated processes and green chemistry techniques, are making the production of intermediates like N-(2-Amino-4-chlorophenyl)-N-(2-chloro-5-fluorophenyl)acetamide more efficient and environmentally friendly.

Regulatory Compliance:

Pharmaceutical companies are increasingly focusing on adhering to global regulatory standards to ensure the quality and safety of intermediates. Stricter regulations are pushing manufacturers to invest in cutting-edge technologies and quality control systems.

Personalized Medicine and Targeted Therapies:

The growing trend towards personalized medicine, especially in oncology, is increasing the demand for intermediates like N-(2-Amino-4-chlorophenyl)-N-(2-chloro-5-fluorophenyl)acetamide. This intermediate plays a key role in the production of drugs designed to target specific molecular pathways in patients.

Conclusion

N-(2-Amino-4-chlorophenyl)-N-(2-chloro-5-fluorophenyl)acetamide (CAS No. 138229-26-1) is an essential pharmaceutical intermediate that plays a pivotal role in the development of targeted therapies, particularly in oncology and inflammation treatments. Leading manufacturers like Lonza, BASF, Eastfine, Mitsubishi Chemical, and others are instrumental in ensuring the high-quality production of this crucial intermediate, helping meet the growing demand for innovative drug therapies.

As the pharmaceutical industry continues to evolve, the importance of intermediates like N-(2-Amino-4-chlorophenyl)-N-(2-chloro-5-fluorophenyl)acetamide will only increase, driving innovation and improving patient outcomes worldwide.


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