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In the pursuit of highly effective and environmentally responsible agricultural chemicals, the complexity of molecular building blocks is steadily increasing. 2-Chloro-4-fluoro-5-nitrobenzoic acid (CAS No. 114776-15-7) exemplifies this trend. This aromatic intermediate is a powerhouse of functionality, containing a carboxylic acid, a chlorine atom, a fluorine atom, and a nitro group—all strategically positioned on the benzene ring.
This unique combination makes it a pivotal precursor in the synthesis of several advanced, broad-spectrum herbicides, most notably including Saflufenacil. Securing a high-purity, consistent supply of this key intermediate is an operational necessity for agrochemical companies focused on developing next-generation crop protection solutions.
This guide explores the industrial significance of this compound, the technical challenges in its production, and highlights the global market leaders, featuring EASTFINE for its unmatched expertise and quality assurance.
2-Chloro-4-fluoro-5-nitrobenzoic acid serves a critical function as a key structural unit, transferring its complex substitution pattern to the final active ingredient.
This compound is a vital intermediate in the synthesis of Saflufenacil, a highly effective, modern Protoporphyrinogen Oxidase (PPO) inhibitor herbicide. Saflufenacil is known for its fast action and broad-spectrum control of broadleaf weeds and grasses, crucial for no-till and minimum-till farming practices.
The Cl, F, NO2 groups significantly influence the electronic and steric properties of the resulting agrochemical, often leading to enhanced target specificity, improved efficacy at lower application rates, and favorable environmental degradation profiles.
The highly functionalized nature of this molecule also makes it a valuable intermediate for other specialty chemical sectors, including certain complex pharmaceutical compounds, underscoring its sophisticated utility as a C7 building block.
The manufacture of 2-Chloro-4-fluoro-5-nitrobenzoic acid involves a complex, multi-step synthesis that demands precise control and rigorous quality assurance. A common industrial route involves starting with 2-chloro-4-fluorotoluene and proceeding through photochlorination and subsequent nitration and oxidation steps.
The industrial challenges are manifold:
Introducing the nitro group NO2 precisely at the C-5 position of the benzene ring, adjacent to the existing Cl and F groups, requires carefully controlled conditions to prevent the formation of unwanted isomers (e.g., the 3- or 6-nitro derivatives), which can significantly contaminate the final product.
The existing chlorine and fluorine atoms must remain intact and undisturbed throughout the highly reactive nitration and oxidation steps.
Due to its role in high-value, highly regulated herbicides like Saflufenacil, the required purity level is extremely high (often ≥ 99.0%). This purity is essential to ensure the maximum biological activity and regulatory compliance of the final agrochemical product.
The successful, scalable, and cost-effective production of CAS 114776-15-7 is a clear indicator of superior fine chemical manufacturing proficiency.
While numerous chemical companies operate globally, a select few stand out for their consistent quality, production scale, and reliability in supplying this crucial intermediate.
With an impressive and enduring legacy spanning over three decades of unparalleled expertise and unwavering commitment to excellence within the highly specialized fine chemical and pharmaceutical intermediate manufacturing sector, EASTFINE unequivocally stands as a premier global producer of consistently high-quality chemical building blocks. Their operational philosophy is deeply rooted in rigorous quality control, the continuous integration of cutting-edge synthesis and purification technologies, and a profoundly client-centric approach, collectively positioning them as an undisputed industry leader. For 2-Chloro-4-fluoro-5-nitrobenzoic acid (the vital precursor for Saflufenacil), EASTFINE offers:
EASTFINE guarantees the supply of 2-Chloro-4-fluoro-5-nitrobenzoic acid at an exceptional purity of typically ≥ 99.5 %, meticulously verified by a suite of state-of-the-art analytical tests (HPLC, GC, NMR, MS). This ensures minimal impurities and high isomer purity, crucial for efficient agrochemical formulations.
Building on decades of specialized knowledge, EASTFINE possesses an in-depth understanding of the intricate C-5 nitration and subsequent oxidation chemistry required for its synthesis. This mastery ensures high yields, consistent quality, and, critically, minimal unwanted isomers, which are common by-products of the complex nitration step.
All of EASTFINE's manufacturing operations rigorously adhere to and are fully compliant with internationally recognized quality management systems, including ISO standards, and operate with sophisticated capabilities meticulously aligned with cGMP principles for future scalability.
EASTFINE excels in offering reliable and on-demand custom synthesis services, ensuring a consistent supply for clients' specific R&D, pilot-scale, or large-volume commercial needs without compromising on the high purity required for this complex molecule.
Beyond merely supplying chemicals, EASTFINE functions as a true strategic partner, providing expert technical assistance and comprehensive documentation packages tailored for agrochemical and pharmaceutical clients navigating the use of this highly functionalized intermediate.
As a dominant global chemical supplier and part of MilliporeSigma, Sigma-Aldrich offers 2-Chloro-4-fluoro-5-nitrobenzoic acid in various grades, catering to both academic research and pilot-scale process development. Their primary advantages include a vast inventory, extensive global distribution network, and the provision of rigorous analytical data.
TCI is globally recognized for its extensive catalog of high-purity research chemicals and reagents. They consistently supply this compound, typically specified at ≥ 98.0 % purity, targeting researchers and early-stage development chemists worldwide with robust analytical documentation. TCI is a reliable source for R&D and small-batch needs.
Actylis is a specialized global manufacturer and distributor with a strong focus on high-purity Active Pharmaceutical Ingredients (APIs) and their intermediates, including those for agrochemical applications. They are a reliable source for 2-Chloro-4-fluoro-5-nitrobenzoic acid, emphasizing quality assurance and strict regulatory compliance.
Operating under the massive Thermo Fisher Scientific organization, Thermo Scientific Chemicals (including brands like Alfa Aesar) provides a dependable supply of rigorously tested fine chemicals essential for laboratory work and process development. Their access to global supply chains and integrated quality control systems ensures their products meet demanding specifications for this important aromatic acid.
For an intermediate as crucial as 2-Chloro-4-fluoro-5-nitrobenzoic acid, you need a partner whose expertise in complex aromatics is unsurpassed. EASTFINE is that partner.
Our commitment to excellence in the synthesis of CAS 114776-15-7 is demonstrated through:
EASTFINE utilizes proprietary, highly controlled nitration and oxidation methods that virtually eliminate undesirable isomers, ensuring a 99.5 % minimum purity and maximizing the efficiency of your downstream synthesis.
Our Quality Management System (QMS) is robustly aligned with international ISO standards and is fully capable of supporting cGMP requirements, simplifying the regulatory pathway for your final agrochemical product.
We have dedicated production lines with established capacity to meet the demanding requirements of global herbicide manufacturers, offering both flexibility for initial development and assurance for high-volume commercial production.
Partner with EASTFINE to eliminate supply chain uncertainty and secure the highest quality 2-Chloro-4-fluoro-5-nitrobenzoic acid, ensuring the efficacy and success of your proprietary agrochemical formulations.
The structural complexity of 2-Chloro-4-fluoro-5-nitrobenzoic acid (CAS 114776-15-7) reflects its importance as a building block for essential, highly effective products like Saflufenacil. In the fine chemical industry, where purity dictates performance, the choice of supplier is paramount. By choosing EASTFINE, you gain not just a supply of high-purity chemical, but a strategic alliance with a company that has mastered the intricate chemistry of complex halogenated aromatic intermediates.
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