Enzalutamide
749927-69-3
White to Off-White Solid
Melting point: 125.0 to 129.0 °C
Boiling point: 284.8±30.0 °C(Predicted)
Density: 1.545±0.06 g/cm3(Predicted)
Storage temp.: Sealed in dry,Room Temperature
Availability: | |
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Product Description
Product Category | Enzalutamide |
CAS NO | 749927-69-3 |
Product Specifications | White to Off-White Solid Melting point: 125.0 to 129.0 °C Boiling point: 284.8±30.0 °C(Predicted) Density: 1.545±0.06 g/cm3(Predicted) Storage temp.: Sealed in dry,Room Temperature |
749927-69-3 4-BROMO-2-FLUORO-N-METHYLBENZAMIDE.pdf
4-Bromo-2-fluoro-N-methylbenzamide is produced by EASTFINE , and we are in charge of overseas selling . Not just trading company .
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4-Bromo-2-fluoro-N-methylbenzamide is an organic molecule with the formula C7H6BrFNO. It consists of a benzamide group, a bromine atom at the para position (4), a fluorine atom at the meta position (2), and an N-methyl group attached to the nitrogen of the amide.
· Benzamide Core: The amide group (-CONH2) gives the molecule versatile reactivity, particularly in nucleophilic substitution and hydrolysis reactions.
· Halogen Substituents: The bromine and fluorine atoms are electron-withdrawing and influence the reactivity of the compound, making it suitable for electrophilic aromatic substitution.
· N-Methyl Group: The N-methyl group enhances the basicity of the nitrogen and modifies the compound’s solubility and reactivity.
4-Bromo-2-fluoro-N-methylbenzamide is primarily used as an intermediate in organic synthesis. It is useful in the development of pharmaceuticals, biologically active compounds, and materials science, where the halogenated aromatic structure plays a key role in the chemical reactivity and biological activity of the final product.
This compound can be synthesized by the following general method:
· Halogenation: A methylbenzamide precursor undergoes halogenation to introduce the bromine and fluorine atoms at the desired positions on the aromatic ring.
· The methylation of the nitrogen atom can be achieved using methylating agents such as methyl iodide (CH3I) in the presence of a base, leading to the formation of the N-methyl derivative.
· Appearance: The compound is generally a solid at room temperature, often white to light yellow.
· Melting Point: The melting point of 4-bromo-2-fluoro-N-methylbenzamide is approximately 135–140°C.
· Solubility: It is likely to be insoluble in water but may dissolve in polar organic solvents such as acetone, methanol, and dimethyl sulfoxide (DMSO).
· As with many organic compounds, especially those with halogen atoms, 4-bromo-2-fluoro-N-methylbenzamide should be handled with care. It may cause irritation to the skin, eyes, and respiratory system.
· Always use appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat, and work in a well-ventilated area.
· Bromine at the para position is an electron-withdrawing group that increases the electrophilicity of the aromatic ring, making the compound more reactive in electrophilic aromatic substitution.
· Fluorine at the meta position also acts as an electron-withdrawing group, but due to its smaller size, it affects the electronic properties of the molecule in a more subtle way, increasing the stability and lipophilicity of the compound.
The compound can be used as a precursor in the synthesis of bioactive molecules, especially those with antimicrobial, anticancer, or anti-inflammatory properties. The halogen atoms (bromine and fluorine) may contribute to the compound's biological activity, lipophilicity, and ability to interact with biological targets.
4-Bromo-2-fluoro-N-methylbenzamide is stable under standard conditions. However, like most organic compounds, it should be stored in a cool, dry place away from moisture and direct sunlight. Ensure that the compound is kept in airtight containers to prevent degradation or contamination.
Halogenated compounds like 4-bromo-2-fluoro-N-methylbenzamide may be persistent in the environment, especially in water or soil. It is important to dispose of this compound according to environmental regulations to avoid contamination. Proper disposal methods, such as using designated waste containers and following institutional guidelines, should be followed to minimize its environmental impact.