Top 10 Manufacturers of Pharmaceutical Intermediate CAS No. 17247-58-4 in 2025

Understanding CAS No. 17247-58-4 – A Key Intermediate for Anti-Tuberculosis and Anti-Infective Drugs

CAS No. 17247-58-4, chemically known as 4-Chlorobenzhydryl chloride, is an important intermediate commonly used in the synthesis of various anti-tuberculosis, antihistamine, and antimicrobial drug substances. It is frequently employed in the preparation of first- and second-generation H1 receptor antagonists and other benzhydryl-based pharmaceutical compounds.

Its stability, reactivity, and compatibility with a wide range of reaction conditions make it an essential building block in drug development pipelines globally.

Importance of CAS No. 17247-58-4 in Pharmaceutical Manufacturing

Essential for Antimicrobial Drug Synthesis

Plays a central role in producing drugs aimed at infectious disease and respiratory treatment markets.

Versatile in Benzhydryl-Based Chemistry

Enables further elaboration into complex heterocyclic and aromatic pharmaceutical structures.

Widely Used in Generics and Off-Patent APIs

Demand is sustained by high-volume production of affordable medicines in global markets.

Stable and Industrially Scalable

Well-suited for bulk synthesis under cGMP, with excellent storage and transport properties.

Global Regulatory Compliance Required

Manufacturers must meet international standards such as USP/EP monographs and ICH Q7 guidelines.

Top 10 Manufacturers of CAS No. 17247-58-4

1. Vertellus

• Location: Indianapolis, Indiana, USA

• Overview: A leading supplier of benzhydryl derivatives and other chlorinated aromatics.

• Specialty: High-purity intermediates for anti-infective and antihistamine drugs.

2. Jubilant Ingrevia

• Location: Uttar Pradesh, India

• Overview: Producer of halogenated intermediates with a focus on scalable, low-impurity chlorination chemistry.

• Specialty: Strong environmental controls and consistent quality across large batches.

3. Eastfine

• Location: Changzhou City, Jiangsu Province, China

• Overview: Trusted international manufacturer of CAS 17247-58-4, serving regulated pharmaceutical markets.

• Specialty: Competitive pricing, export-ready documentation, and compliance with global GMP standards.

4. Farmhispania Group

• Location: Barcelona, Spain

• Overview: EU-based manufacturer with expertise in anti-infective intermediates and process scale-up.

• Specialty: Full regulatory support and flexible production capacities.

5. Aarti Pharmalabs

• Location: Maharashtra, India

• Overview: Global producer of chlorinated aromatics and benzhydryl compounds used in generics.

• Specialty: Integrated supply chain and cGMP-certified operations.

6. Sterling Pharma Solutions

• Location: Newcastle, UK

• Overview: Specializes in high-hazard chemistry, including chlorinated intermediates.

• Specialty: Focus on controlled processes, containment, and regulatory inspections.

7. Neuland Laboratories

• Location: Hyderabad, India

• Overview: Manufacturer of intermediates for anti-TB and antimicrobial APIs.

• Specialty: Strong analytical capabilities and global compliance track record.

8. Delmar Chemicals

• Location: Montreal, Canada

• Overview: North American supplier of small molecule intermediates, including benzhydryl-based compounds.

• Specialty: Flexible production volumes and regulatory documentation support.

9. WeylChem International

• Location: Frankfurt, Germany

• Overview: Experienced in chlorination chemistry and fine chemical manufacturing for pharmaceuticals.

• Specialty: Custom synthesis and full traceability under EU regulatory systems.

10. Curia Global (formerly AMRI)

• Location: Albany, New York, USA

• Overview: CDMO with process chemistry expertise in producing niche intermediates like 4-Chlorobenzhydryl chloride.

• Specialty: Route development, regulatory filings, and reliable batch delivery.

Trends in the Pharmaceutical Intermediates Market

Rising Demand for Anti-TB and Anti-Infective Drugs

Global health initiatives and reemergence of infectious diseases are pushing demand for intermediates like CAS 17247-58-4.

Shift Toward Cost-Effective Generic Manufacturing

Intermediates used in legacy and generic drugs remain critical for access-oriented global markets.

Improved Handling of Halogenated Compounds

Advanced safety protocols and waste management are making chlorinated intermediate production more sustainable.

Emphasis on Regulatory Readiness

Full transparency in impurity profiling, stability data, and documentation is now mandatory for global suppliers.

Resilience Through Global Supply Diversification

Buyers are seeking geographically distributed suppliers to mitigate risk and ensure supply continuity.

Conclusion

CAS No. 17247-58-4, or 4-Chlorobenzhydryl chloride, is a highly relevant intermediate used in anti-infective and antihistamine drug synthesis. Leading manufacturers such as Eastfine, Vertellus, Jubilant, and Farmhispania play key roles in maintaining a consistent and compliant supply of this essential chemical building block.

As global healthcare systems focus on improving access to essential medications, high-quality and cost-effective intermediates like CAS 17247-58-4 will remain a priority for formulators, CDMOs, and public health procurement programs worldwide.