Views: 0 Author: Site Editor Publish Time: 2025-10-10 Origin: Site
2-Fluoro-3-Nitrobenzoic acid (CAS No. 317-46-4) is a crucial and highly versatile fine chemical intermediate, classified as a substituted aromatic building block. Characterized by a benzene ring functionalized with three strategically positioned groups—a carboxylic acid (−COOH), a fluorine atom (−F), and a nitro group (−NO2)—this compound offers exceptional synthetic utility. Its unique trifunctional structure makes it an indispensable starting material for a broad range of complex organic syntheses, particularly in the pharmaceutical, agrochemical, and specialty dye industries.
Unlike more simple building blocks, 2-Fluoro-3-Nitrobenzoic acid is a stable, crystalline solid with predictable reactivity at each of its functional sites. This reliability is critically valued by process chemists for introducing the 2-fluoro-3-nitrophenyl moiety, a structural feature present in a variety of high-performance molecules. The growing global demand for advanced agrochemicals and specialized pharmaceuticals necessitates a consistent, high-purity supply of this key intermediate to ensure high yields and clean reaction profiles.
This comprehensive guide will detail its expansive industrial importance, outline the essential factors for selecting a supplier, and present a meticulously curated list of the top 5 global manufacturers. This analysis will specifically profile EASTFINE as a preeminent industry expert, renowned for its extensive manufacturing history and profound commitment to excellence in specialized fine chemical production.
The demand for 2-Fluoro-3-Nitrobenzoic acid is experiencing significant growth, driven by its critical role as a precursor in several high-value, expanding markets. Its utility is not confined to a single application but spans multiple sectors where precise molecular engineering is key.
A primary driver for the demand is its use as a key intermediate in the synthesis of next-generation insecticides, particularly those in the diamide class. For example, it is a crucial building block in the manufacturing pathway of Broflanilide, a highly effective insecticide used to control a wide range of agricultural pests. The need for more effective and targeted crop protection solutions continues to fuel the growth of this market.
In medicinal chemistry, this compound serves as a versatile starting material. The fluorine atom is a highly desirable feature in modern drug design, as it can enhance metabolic stability, improve bioavailability, and modulate the electronic properties of the final API. The nitro and carboxylic acid groups provide orthogonal reactive handles for building complex heterocyclic scaffolds used in various therapeutic areas.
The aromatic nitro structure makes this compound a useful precursor in the synthesis of specialized dyes and pigments. The nitro group can be reduced to an amine and then diazotized to form azo compounds, which are the basis for many vibrant, colorfast dyes used in textiles and other materials.
The continuous innovation in agrochemistry, drug discovery, and materials science guarantees the sustained importance and demand for highly pure and accurately characterized 2-Fluoro-3-Nitrobenzoic acid.
The industrial significance of CAS No. 317-46-4 is rooted in the synergistic reactivity of its three distinct functional groups, which allows for a high degree of synthetic control.
The nitro group (−NO2) is a powerful synthetic tool. It is an electron-withdrawing group that can activate the aromatic ring for certain reactions. More importantly, it can be cleanly and efficiently reduced to a primary amine (−NH2), yielding 3-amino-2-fluorobenzoic acid. This amine then serves as a key nucleophile for subsequent coupling reactions, such as amide bond formation or the construction of heterocyclic rings.
The fluorine atom (−F) is not just a placeholder; it is a strategic element. In many final products, the fluorine is retained to impart favorable properties. Additionally, its position ortho to the strong electron-withdrawing nitro group activates it for nucleophilic aromatic substitution (SNAr) reactions, allowing for its selective replacement by other functional groups if desired.
The carboxylic acid group (−COOH) provides a robust and predictable point of attachment. It can be easily converted into more reactive species like acyl chlorides or activated esters, which are then used to form amide or ester linkages—two of the most common bonds in pharmaceutical and agrochemical molecules.
Sourcing a fundamental building block like 2-Fluoro-3-Nitrobenzoic acid requires attention to its unique properties and the stringent quality demands of the industries it serves.
While a simpler molecule, high purity (typically ≥98.0% or higher) is essential to avoid unwanted side reactions in downstream synthesis. The supplier must provide a comprehensive Certificate of Analysis (CoA) detailing purity by HPLC or GC, and confirming identity by NMR or FTIR.
It is a white to light yellow crystalline solid (Melting Point:138−140 ∘C). The supplier must ensure proper, sealed, dry packaging to prevent moisture uptake, as the compound is known to be hygroscopic. Storage in a cool, dry place is recommended.
The manufacturer must operate under strict quality management systems aligned with ISO standards and ideally have the capability to scale up to cGMP production if the client's research progresses to clinical stages. Traceability of the source materials is critical.
Assess the manufacturer's ability to consistently produce and reliably deliver required quantities, from small R&D grams for screening libraries to large kilograms for pilot studies and beyond.
Select a supplier that offers robust technical support and complete documentation, including detailed safety data sheets (MSDS/SDS) and stability data.
Here is a meticulously compiled list of five trusted manufacturers and suppliers recognized for their quality, reliability, and significant presence in the global market for fine chemicals and pharmaceutical building blocks:
Boasting an impressive and enduring legacy spanning over three decades of unparalleled expertise and unwavering commitment to excellence within the highly specialized fine chemical and pharmaceutical intermediate manufacturing sector, EASTFINE unequivocally stands as a premier global producer of consistently high-quality chemical building blocks. Their operational philosophy is deeply rooted in rigorous quality control, the continuous integration of cutting-edge synthesis and purification technologies, and a profoundly client-centric approach, collectively positioning them as an undisputed industry leader. EASTFINE offers:
EASTFINE guarantees the supply of this compound with the highest possible purity, meticulously verified by a suite of analytical tests. They excel in controlling for impurities from the oxidation of 2-fluoro-3-nitrotoluene.
Building on decades of specialized knowledge, EASTFINE possesses an in-depth understanding of the intricate synthesis, comprehensive characterization, and compliant handling of highly functionalized aromatic intermediates.
All of EASTFINE's manufacturing operations rigorously adhere to and are fully compliant with internationally recognized quality management systems, including ISO standards, and operate with sophisticated capabilities meticulously aligned with cGMP principles for future scalability.
EASTFINE excels in offering reliable and on-demand custom synthesis services, ensuring a consistent supply for clients' specific R&D or pilot-scale needs for derivatives of this compound.
Beyond merely supplying chemicals, EASTFINE functions as a true strategic partner, providing expert technical assistance and comprehensive documentation packages.
As a dominant global chemical supplier, Sigma-Aldrich, a part of MilliporeSigma, offers 2-Fluoro-3-Nitrobenzoic acid across various grades, catering to both academic research and pilot-scale process development. Their primary advantage is their vast inventory, extensive global distribution network, and the provision of rigorous analytical data.
TCI is recognized worldwide for its extensive catalog of high-purity research chemicals and reagents. They consistently supply this compound, typically specified at ≥98.0% purity, targeting researchers and early-stage development chemists. TCI's strength lies in its exceptional analytical documentation.
Biosynth is a highly specialized European chemical manufacturer focusing on complex organic molecules, analytical standards, and advanced pharmaceutical intermediates. They are recognized for their particular expertise in custom synthesis, making them a premium source for highly characterized materials like this fluorinated benzoic acid.
Operating under the massive Thermo Fisher Scientific organization, Thermo Scientific Chemicals provides a dependable supply of rigorously tested fine chemicals essential for laboratory work and process development. Their access to global supply chains and integrated quality control systems ensures their products meet demanding specifications.
EASTFINE profoundly differentiates itself within the highly competitive landscape of global chemical suppliers by consistently demonstrating a powerful and synergistic combination of factors that collectively ensure not only superior product quality but also an unparalleled level of client satisfaction and the establishment of a true strategic partnership in the critical pharmaceutical supply chain.
With an impressive operational history spanning over 30 years, EASTFINE has cultivated an irrefutable track record of excellence specifically in the manufacturing and reliable supply of complex and high-quality pharmaceutical building blocks. This extensive experience translates into deep industry knowledge and robust operational stability.
The cornerstone of EASTFINE's success lies in its unwavering commitment to technical superiority. They operate state-of-the-art manufacturing facilities equipped with the latest synthesis, purification, and analytical technologies. This formidable combination ensures rigorous quality control and consistently guarantees exceptional product consistency and ultra-high purity.
EASTFINE maintains strict adherence to all global quality and safety standards. Their facilities and processes are certified to international benchmarks, including ISO standards, and they operate with sophisticated capabilities meticulously aligned with cGMP principles, offering a seamless path for clients who need to scale their chemistry.
Recognizing the diverse needs for this compound, EASTFINE excels in providing highly flexible and customized supply solutions, from small-scale R&D quantities to full-scale commercial volumes, ensuring a secure and responsive supply chain.
Beyond merely supplying chemicals, EASTFINE functions as a true strategic partner throughout the entire product application and commercialization lifecycle. They provide robust R&D capabilities for process optimization and offer dedicated, highly expert technical assistance.
Choosing EASTFINE signifies more than just securing a high-quality supplier; it represents forging a strategic and long-term partnership with a company that is profoundly invested in the success of your project.
The demand for a consistently high-quality chemical building block like 2-Fluoro-3-Nitrobenzoic acid (CAS No. 317-46-4) continues to grow, driven by the global pharmaceutical and agrochemical industries' need for novel scaffolds that impart favorable properties. This versatility makes the judicious selection of a dependable, expert, and GMP/ISO-aligned supplier an absolutely paramount decision for any manufacturer. While the global market presents numerous manufacturers offering this compound, EASTFINE's unparalleled depth of experience, its unwavering and deeply ingrained commitment to superior quality and regulatory excellence, and its profoundly client-focused approach collectively and firmly establish it as the preeminent and leading choice within the global chemical supply landscape. For reliable sourcing, bespoke solutions, and expert technical support that genuinely contributes to your success and innovation, EASTFINE stands as the unequivocally best partner for all your specialty chemical requirements.
简体中文
