English
Apalutamide
573762-62-6
Boiling point: 362.2±42.0 °C(Predicted)
Density: 1.45±0.1 g/cm3(Predicted)
Storage temp.: Keep in dark place,Inert atmosphere,Room temperature
Product Description
Product Category | Apalutamide |
CAS NO | 573762-62-6 |
Product Specifications | Boiling point: 362.2±42.0 °C(Predicted) Density: 1.45±0.1 g/cm3(Predicted) Storage temp.: Keep in dark place,Inert atmosphere,Room temperature |
573762-62-6 5-AMINO-3-(TRIFLUOROMETHYL) PICOLINONITRILE.pdf
5-Amino-3-(trifluoroMethyl) picolinonitrile is produced by EASTFINE , and we are in charge of overseas selling . Not just trading company .
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5-Amino-3-(trifluoromethyl)picolinonitrile is an organic molecule with the chemical formula C7H5F3N2. It is a pyridine derivative containing an amino group (-NH2) at the 5-position, a trifluoromethyl group (-CF3) at the 3-position, and a nitrile group (-CN) at the 2-position of the pyridine ring. This structure gives it distinct electronic and chemical properties, making it useful in various synthetic applications.
· Amino Group (–NH2): The amino group at the 5-position makes the compound basic and reactive in nucleophilic reactions.
· Trifluoromethyl Group (–CF3): The trifluoromethyl group is an electron-withdrawing group, which affects the reactivity and stability of the molecule.
· Nitrile Group (–CN): The nitrile group at the 2-position is a highly reactive group that can undergo nucleophilic addition and other organic transformations.
· Organic Synthesis: This compound is widely used as an intermediate in the synthesis of various organic molecules, particularly in creating fluorinated heterocycles and bioactive compounds.
· Pharmaceuticals: Due to the presence of the amino, trifluoromethyl, and nitrile groups, this molecule can be a precursor for developing pharmaceutical agents with enhanced bioactivity.
· Material Science: It can also be used in the preparation of specialized polymers or fluorinated materials due to the influence of the trifluoromethyl group.
5-Amino-3-(trifluoromethyl)picolinonitrile can be synthesized through various methods, typically involving the functionalization of a picolinic acid derivative or a pyridine precursor:
· Trifluoromethylation: One approach is to introduce the trifluoromethyl group (–CF3) at the 3-position of the pyridine ring via electrophilic substitution reactions.
· Amination: The amino group can be introduced by reductive amination or direct amination of the appropriate pyridine derivative.
· Nitrilation: The nitrile group is often introduced via nitration or cyanation reactions.
· Appearance: This compound is typically a solid at room temperature.
· Solubility: 5-Amino-3-(trifluoromethyl)picolinonitrile is likely soluble in organic solvents such as acetone, ethanol, and dimethyl sulfoxide (DMSO), but insoluble in water due to its relatively hydrophobic nature from the trifluoromethyl group.
· Melting Point: The exact melting point may vary, but compounds of this type typically have moderate melting points due to the pyridine ring and functional groups.
The trifluoromethyl group (-CF3) is an electron-withdrawing group that significantly influences the molecule's electronic properties. This group can:
· Increase the lipophilicity of the molecule, making it more fat-soluble.
· Enhance the stability of the compound by reducing the basicity of the nitrogen and slowing down certain reactions.
· Make the molecule more reactive in certain types of chemical transformations due to the strong electron-withdrawing nature of the CF3 group.
Like many organic compounds, 5-Amino-3-(trifluoromethyl)picolinonitrile should be handled with care. It may cause irritation to the skin, eyes, and respiratory system if inhaled or in contact with skin. As a precaution:
· Wear appropriate protective equipment such as gloves, goggles, and a lab coat.
· Use the compound in a well-ventilated area or under a fume hood.
· If accidental contact occurs, rinse the affected area thoroughly with water and seek medical advice if necessary.
· Nucleophilic Substitution: The nitrile group and the amino group in the compound can undergo nucleophilic substitution reactions, particularly with electrophilic reagents.
· Electrophilic Substitution: The trifluoromethyl group can participate in electrophilic aromatic substitution reactions under appropriate conditions.
· Coupling Reactions: The amino group may undergo coupling reactions with other electrophiles, especially in the synthesis of bioactive compounds or pharmaceuticals.
Yes, this compound, due to its functional groups, could be used in drug discovery. The amino group makes it reactive for the formation of amide bonds, while the trifluoromethyl group enhances lipophilicity and bioavailability, which is often desirable in drug design. The nitrile group provides further versatility in synthetic biology or medicinal chemistry applications.
5-Amino-3-(trifluoromethyl)picolinonitrile is generally stable under normal conditions. However, the compound may be sensitive to strong acids, bases, or oxidizing agents, which could lead to the degradation of the functional groups. It should be stored in a cool, dry place away from extreme conditions.
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