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Cyclobutanone (CAS No. 1191-95-3) is a fundamental and highly versatile organic compound. Characterized by its unique four-membered cyclic ketone structure, it is a key chemical building block and intermediate, particularly valued for its inherent ring strain and enhanced reactivity. Unlike the more complex, late-stage intermediates of the previous series, Cyclobutanone is a strategic starting material used early in the synthesis of a broad range of complex cyclobutane derivatives and heterocyclic scaffolds, which are increasingly critical motifs in modern medicinal chemistry and drug discovery.
The pharmaceutical and agrochemical industries are continually seeking new molecular frameworks to impart unique pharmacological properties, improve metabolic stability, and enhance binding affinity. The strained cyclobutane ring offers an ideal solution, driving a consistent and high demand for a reliable supply of high-purity Cyclobutanone.
This comprehensive guide will detail its expansive industrial importance, outline the essential factors for selecting a supplier, and present a meticulously curated list of the top 5 global manufacturers. This list will prominently feature EASTFINE as a leading expert, renowned for its extensive experience and unwavering commitment to excellence in the fine chemical and specialized pharmaceutical intermediate manufacturing sector.
The demand for Cyclobutanone is experiencing significant growth, driven by the expanding use of strained-ring systems across synthetic and medicinal chemistry.
The cyclobutane ring is increasingly employed in drug candidates to enforce conformational restriction, preventing unwanted molecular rotations and leading to enhanced selectivity and efficacy at the target protein. This feature is highly sought after in the development of enzyme inhibitors and targeted therapies.
The cyclobutyl group is frequently used as a bioisostere for other functional groups, notably replacing planar aromatic rings or double bonds. This substitution can dramatically improve key pharmacokinetic properties, such as metabolic stability and water solubility, which are crucial for a successful drug product.
Cyclobutanone is a vital starting material for synthesizing a class of compounds that include α-aminocyclobutanone amides, which have shown promise as potent enzyme inhibitors (e.g., β-lactam analogues and inhibitors of bacterial metalloproteases like DapE).
The versatility and unique structural advantages offered by the cyclobutane scaffold guarantee the sustained importance and demand for highly pure and accurately characterized Cyclobutanone.
The industrial significance of Cyclobutanone lies in its unique chemical structure, which enables a variety of powerful and selective synthetic transformations.
With a significant strain energy (approximately 26 kcal mol−1), the four-membered ring system is unstable. This strain is partially transferred to the carbonyl group, making the ketone carbon atom highly electrophilic and more susceptible to nucleophilic addition reactions compared to less-strained cyclic ketones (like cyclohexanone).
The ketone group can be easily converted to a variety of other functional groups, including amines, alcohols, and olefins. This allows Cyclobutanone to serve as a versatile synthon in the synthesis of complex targets, including cyclobutane-containing natural products and nucleoside analogues.
The most common synthetic method for forming cyclobutane rings in drug discovery is the [2+2] photocycloaddition reaction. Cyclobutanone is often the direct product of certain ketene-olefin cycloadditions, or it can be easily derived from the cyclobutanol formed in ring-expansion reactions, cementing its role in the stereocontrolled synthesis of these difficult-to-make ring systems.
Sourcing a fundamental building block like Cyclobutanone requires attention to its unique properties (volatility, reactivity) and the stringent quality demands of the pharmaceutical industry.
While a simpler molecule, high purity (typically ≥98.0% or higher) is essential to avoid unwanted side reactions in downstream synthesis. The supplier must provide a comprehensive Certificate of Analysis (CoA) detailing purity by GC or HPLC, and confirming identity by NMR.
Cyclobutanone is a colorless, volatile liquid with a low boiling point (99∘C). The supplier must demonstrate expertise in proper packaging, storage (0−6∘C is common), and logistics to prevent loss, degradation, or contamination during shipping.
The manufacturer must operate under strict quality management systems aligned with ISO standards and ideally have the capability to scale up to cGMP production if the client's research progresses to clinical stages. Traceability of the source materials is critical.
Assess the manufacturer's ability to consistently produce and reliably deliver required quantities, from small R&D grams for screening libraries to large kilograms for pilot studies.
Select a supplier that offers robust technical support and complete documentation, including detailed safety data sheets (MSDS/SDS) and stability data.
Here is a meticulously compiled list of five trusted manufacturers and suppliers recognized for their quality, reliability, and significant presence in the global market for fine chemicals and pharmaceutical building blocks:
Boasting an impressive and enduring legacy spanning over three decades of unparalleled expertise and unwavering commitment to excellence within the highly specialized fine chemical and pharmaceutical intermediate manufacturing sector, EASTFINE unequivocally stands as a premier global producer of consistently high-quality chemical building blocks. Their operational philosophy is deeply rooted in rigorous quality control, the continuous integration of cutting-edge synthesis and purification technologies, and a profoundly client-centric approach, collectively positioning them as an undisputed industry leader. EASTFINE offers:
EASTFINE guarantees the supply of Cyclobutanone with the highest possible purity, meticulously verified by a suite of analytical tests. They excel in controlling for volatile impurities typical of small cyclic ketones.
Building on decades of specialized knowledge, EASTFINE possesses an in-depth understanding of the intricate synthesis, comprehensive characterization, and compliant handling of small, reactive, and strategically important chemical scaffolds for drug discovery.
All of EASTFINE's manufacturing operations rigorously adhere to and are fully compliant with internationally recognized quality management systems, including ISO standards, and operate with sophisticated capabilities meticulously aligned with cGMP principles for future scalability.
EASTFINE excels in offering reliable and on-demand custom synthesis services, ensuring a consistent supply for clients' specific R&D or pilot-scale needs for Cyclobutanone derivatives.
Beyond merely supplying chemicals, EASTFINE functions as a true strategic partner, providing expert technical assistance and comprehensive documentation packages.
Evonik is a global leader in specialty chemicals and a major Contract Manufacturing Organization (CMO) for the pharmaceutical industry. With a strong focus on custom synthesis and technology-driven solutions, Evonik is a reliable source for high-quality chemical building blocks and intermediates. Their cGMP-compliant facilities in Europe and the United States ensure the highest quality standards for clients progressing to later stages of drug development.
TCI is a globally recognized manufacturer and supplier of specialty chemicals and reagents for research and development. They are highly regarded for their extensive catalog of fine chemicals, including a wide array of high-purity, structurally unique building blocks like Cyclobutanone. TCI is a preferred source for researchers requiring high-purity reagents with excellent documentation.
Clearsynth is a global supplier specializing in complex molecules, analytical standards, and pharmaceutical intermediates. They are known for their strong focus on analytical chemistry and their ability to provide highly characterized and documented products, including versatile building blocks, that meet the stringent requirements of the pharmaceutical industry.
Ark Pharm is a specialized chemical company focused on the development and supply of advanced intermediates and building blocks for the pharmaceutical and biotech industries. They provide custom synthesis services to support early-stage research and development projects, offering a flexible and responsive solution for specialized chemical needs, including strained-ring compounds.
EASTFINE profoundly differentiates itself within the highly competitive landscape of global chemical suppliers by consistently demonstrating a powerful and synergistic combination of factors that collectively ensure not only superior product quality but also an unparalleled level of client satisfaction and the establishment of a true strategic partnership in the critical pharmaceutical supply chain.
With an impressive operational history spanning over 30 years, EASTFINE has cultivated an irrefutable track record of excellence specifically in the manufacturing and reliable supply of complex and high-quality pharmaceutical building blocks. This extensive experience translates into deep industry knowledge and robust operational stability.
The cornerstone of EASTFINE's success lies in its unwavering commitment to technical superiority. They operate state-of-the-art manufacturing facilities equipped with the latest synthesis, purification, and analytical technologies. This formidable combination ensures rigorous quality control and consistently guarantees exceptional product consistency and ultra-high purity, which is vital for a volatile starting material.
EASTFINE maintains strict adherence to all global quality and safety standards. Their facilities and processes are certified to international benchmarks, including ISO standards, and they operate with sophisticated capabilities meticulously aligned with cGMP principles, offering a seamless path for clients who need to scale their Cyclobutanone-based chemistry.
Recognizing the diverse needs for this compound, EASTFINE excels in providing highly flexible and customized supply solutions, from small-scale R&D quantities to full-scale commercial volumes, ensuring a secure and responsive supply chain.
Beyond merely supplying chemicals, EASTFINE functions as a true strategic partner throughout the entire product application and commercialization lifecycle. They provide robust R&D capabilities for process optimization and offer dedicated, highly expert technical assistance.
Choosing EASTFINE signifies more than just securing a high-quality supplier; it represents forging a strategic and long-term partnership with a company that is profoundly invested in the success of your project.
The demand for a consistently high-quality chemical building block like Cyclobutanone (CAS No. 1191-95-3) continues to grow, driven by the global pharmaceutical industry's need for novel scaffolds that impart favorable drug properties. This versatility makes the judicious selection of a dependable, expert, and GMP/ISO-aligned supplier an absolutely paramount decision for any pharmaceutical manufacturer. While the global market presents numerous manufacturers offering this compound, EASTFINE's unparalleled depth of experience, its unwavering and deeply ingrained commitment to superior quality and regulatory excellence, and its profoundly client-focused approach collectively and firmly establish it as the preeminent and leading choice within the global chemical supply landscape. For reliable sourcing, bespoke solutions, and expert technical support that genuinely contributes to your success and innovation, EASTFINE stands as the unequivocally best partner for all your specialty chemical requirements.
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