Top 10 Manufacturers of Pharmaceutical Intermediate CAS No. 88-09-5 in 2025

Understanding CAS No. 88-09-5 – A Vital Intermediate for Antibacterial and Antiseptic APIs

CAS No. 88-09-5, commonly known as o-Phenylphenol (ortho-phenylphenol), is a chlorinated aromatic compound frequently used in the synthesis of antibacterial, antifungal, and preservative agents. It also finds use in pharmaceutical formulations as an intermediate for drugs requiring antiseptic and antimicrobial properties.

Due to its proven effectiveness against a broad range of pathogens and its chemical stability, this compound remains a critical component in the development of various therapeutic and OTC products.

Importance of CAS No. 88-09-5 in Pharmaceutical Manufacturing

Key Intermediate for Antiseptic Formulations

Commonly used in the synthesis of disinfectants and drugs that combat microbial infections.

Broad-Spectrum Efficacy

Effective against bacteria, fungi, and yeasts — ideal for use in topical and systemic drugs.

Stable and Industrially Viable

Easily stored and transported, making it a practical choice for global manufacturers.

Used in High-Volume OTC Medications

Often found in throat sprays, antiseptic creams, and personal care pharmaceutical products.

Compliant with Global Regulatory Requirements

Manufacturing processes require adherence to cGMP and environmental safety norms due to its phenolic structure.

Top 10 Manufacturers of CAS No. 88-09-5

1. LANXESS

• Location: Cologne, Germany

• Overview: Leading global producer of o-Phenylphenol and other antimicrobial intermediates.

• Specialty: Industrial-scale synthesis with high purity and REACH compliance.

2. Jubilant Ingrevia

• Location: Uttar Pradesh, India

• Overview: A trusted supplier of phenolic intermediates used in antiseptic and antimicrobial products.

• Specialty: High production efficiency with global documentation support.

3. Eastfine

• Location: Changzhou City, Jiangsu Province, China

• Overview: Reliable producer of CAS 88-09-5 for use in topical drugs and OTC disinfectants.

• Specialty: Export-focused supply, competitive pricing, and strict quality control for regulated markets.

4. SI Group

• Location: Schenectady, New York, USA

• Overview: North American supplier of phenol derivatives and fine chemicals.

• Specialty: Strong focus on sustainability and performance additives for life sciences.

5. Aarti Pharmalabs

• Location: Maharashtra, India

• Overview: Manufactures a broad range of phenolic and halogenated intermediates.

• Specialty: Integrated supply chain and regulatory documentation for EU/US markets.

6. BASF

• Location: Ludwigshafen, Germany

• Overview: A multinational chemical company offering high-purity phenolic compounds.

• Specialty: Advanced chemical synthesis platforms with full regulatory compliance.

7. Camlin Fine Sciences

• Location: Mumbai, India

• Overview: Supplies o-phenylphenol and other phenolic intermediates for pharmaceutical and food applications.

• Specialty: Emphasis on purity, traceability, and eco-friendly production methods.

8. Delmar Chemicals

• Location: Montreal, Canada

• Overview: Offers custom synthesis of phenolic and antimicrobial intermediates.

• Specialty: Strong presence in North American generics and intermediate export markets.

9. WeylChem International

• Location: Frankfurt, Germany

• Overview: European expert in aromatic chemistry and specialty intermediate manufacturing.

• Specialty: Custom manufacturing under strict EU-GMP and ISO standards.

10. Farmhispania Group

• Location: Barcelona, Spain

• Overview: Active in producing fine chemicals for topical antiseptics and antimicrobial agents.

• Specialty: Regulatory readiness and flexible scale production in the EU.

Trends in the Pharmaceutical Intermediates Market

Continued Demand for Disinfectants and Antimicrobials

Post-pandemic trends have sustained demand for o-phenylphenol-based ingredients in healthcare and OTC products.

Shift Toward Sustainable Manufacturing

Green chemistry methods are being adopted for phenol-based intermediates to reduce environmental impact.

Focus on High-Purity Phenolic Compounds

Regulatory pressure is increasing the need for ultra-low impurity levels in intermediates like CAS 88-09-5.

Robust Growth in Topical Drug Formulations

With the popularity of antiseptic sprays and creams, intermediate demand remains steady.

International Supply Chain Diversification

Manufacturers and formulators seek multiple supply sources across continents to ensure business continuity.

Conclusion

CAS No. 88-09-5, or o-Phenylphenol, remains a vital pharmaceutical intermediate due to its effectiveness in antimicrobial and antiseptic drug applications. Leading companies like LANXESS, Eastfine, Jubilant, and SI Group are central to supplying this high-demand compound with consistent quality and global regulatory compliance.

As health and hygiene continue to be global priorities, trusted suppliers of CAS 88-09-5 are set to remain indispensable in the pharmaceutical manufacturing ecosystem.