Top 10 Manufacturers of Pharmaceutical Intermediate CAS No. 32122-23-9 in 2025

Understanding CAS No. 32122-23-9 – A Core Intermediate in Cardiovascular Drug Synthesis

CAS No. 32122-23-9, chemically known as 4-Amino-3,5-dichloroacetophenone, is a critical intermediate commonly used in the synthesis of active pharmaceutical ingredients (APIs) for cardiovascular and anti-inflammatory drugs, as well as certain antihypertensive agents.

Its versatility, stability, and reactivity make it a valuable building block in numerous multi-step syntheses. The high demand for related APIs across global therapeutic markets continues to drive interest in quality production of this intermediate.

Importance of CAS No. 32122-23-9 in Pharmaceutical Manufacturing

Essential for Cardiovascular API Synthesis

Integral to the production of several antihypertensive and anti-inflammatory APIs.

Key in Aromatic Amination Pathways

Its amino and ketone groups make it ideal for further functionalization in synthetic chemistry.

Stable and Scalable for Industrial Use

Can be manufactured in bulk under controlled conditions, supporting high-volume demand.

Required for Both Generic and Branded Drug Manufacturing

Used globally in regulated and semi-regulated markets.

Subject to Regulatory Quality Standards

Must be produced in GMP-compliant facilities with validated analytical methods.

Top 10 Manufacturers of CAS No. 32122-23-9

1. Farmhispania Group

• Location: Barcelona, Spain

• Overview: Known for its broad portfolio of aromatic intermediates, including those for cardiovascular and anti-inflammatory drugs.

• Specialty: EU-GMP certified, with custom synthesis and scale-up expertise.

2. Vertellus

• Location: Indianapolis, Indiana, USA

• Overview: Specializes in nitro and chloroaromatic compounds for pharmaceutical intermediates.

• Specialty: Strong in ketone derivatives and industrial-scale fine chemicals.

3. Eastfine

• Location: Changzhou City, Jiangsu Province, China

• Overview: A trusted supplier of 4-Amino-3,5-dichloroacetophenone with strong technical capability and international reach.

• Specialty: High-quality production with competitive pricing and full regulatory documentation.

4. Neuland Laboratories

• Location: Hyderabad, India

• Overview: A global manufacturer of pharmaceutical intermediates and APIs, particularly in the cardiovascular segment.

• Specialty: Backward-integrated operations and cGMP-compliant manufacturing.

5. Jubilant Ingrevia

• Location: Uttar Pradesh, India

• Overview: Offers a range of chlorinated intermediates used in pharmaceuticals and agrochemicals.

• Specialty: Large-scale capacity with focus on process efficiency and environmental compliance.

6. Sterling Pharma Solutions

• Location: Newcastle, UK

• Overview: Contract manufacturer of halogenated aromatics and custom intermediates for regulated markets.

• Specialty: Specializes in high-complexity, multi-step synthesis.

7. Delmar Chemicals

• Location: Montreal, Canada

• Overview: Offers custom synthesis of pharmaceutical intermediates under GMP, with expertise in halogenated aromatic compounds.

• Specialty: Regulatory support and small-to-medium batch flexibility.

8. Aarti Pharmalabs

• Location: Maharashtra, India

• Overview: A leader in chlorinated and nitro intermediates used in cardiovascular and CNS drugs.

• Specialty: Strong R&D and cost-effective large-scale manufacturing.

9. WeylChem International

• Location: Frankfurt, Germany

• Overview: Part of the International Chemical Investors Group, producing fine chemicals including specialty halogenated intermediates.

• Specialty: Custom development and toll manufacturing under strict QA systems.

10. Curia Global (formerly AMRI)

• Location: Albany, New York, USA

• Overview: US-based CDMO with deep experience in aromatic amine derivatives and complex organic chemistry.

• Specialty: Full lifecycle support, from route development to commercial-scale production.

Trends in the Pharmaceutical Intermediates Market

Cardiovascular Drug Demand Remains Strong

Aging populations and chronic conditions drive the need for intermediates like CAS 32122-23-9.

Growth in Generic Drug Manufacturing

Intermediates for established drugs are in demand across India, Latin America, and Africa.

Emphasis on Regulatory Readiness

Buyers increasingly demand full impurity profiles and DMF support for intermediates.

Shift Toward Green Chemistry

Use of safer chlorinating agents and waste treatment innovations in halogenated intermediate production.

Diversification of Global Supply Chains

Manufacturers in India, Europe, and North America are increasing output to reduce reliance on any single region.

Conclusion

CAS No. 32122-23-9 is a vital intermediate in the production of multiple cardiovascular and anti-inflammatory drugs. With strong global demand and a focus on quality and compliance, suppliers like Eastfine, Farmhispania, Neuland, and Sterling Pharma are leading the way in providing consistent and cost-effective supply.

As the pharmaceutical industry continues to expand its global reach and quality expectations, the importance of reliable intermediate manufacturers will only grow—especially for compounds like 4-Amino-3,5-dichloroacetophenone that serve as the foundation for life-saving medications.