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In the global effort to ensure food security, the discovery of Flubendiamide (CAS No. 272451-61-3) marked a historic breakthrough. It was the first commercial insecticide to belong to the phthalic acid diamide class, introducing a completely novel mode of action that targets the ryanodine receptors in insect muscles.
By causing an uncontrolled release of calcium ions, Flubendiamide induces rapid contraction and paralysis in target pests, particularly larvae of moths and butterflies. Its complex structure—featuring an iodine atom, seven fluorine atoms, and a methylthio side chain—is meticulously engineered to provide long-lasting protection while remaining remarkably safe for beneficial insects, pollinators, and mammals.
The demand for Flubendiamide continues to rise as farmers seek high-potency alternatives to older chemistries like organophosphates or pyrethroids.
It is exceptionally effective against a wide range of destructive pests, including the Fall Armyworm, Diamondback Moth, and various bollworms that threaten corn, cotton, rice, and vegetable crops.
Because it is highly selective and has low toxicity to non-target organisms like bees and predatory mites, Flubendiamide is a cornerstone of modern IPM programs worldwide.
Its unique mode of action makes it a vital tool for managing pest populations that have developed resistance to other insecticide classes, ensuring the longevity of crop protection strategies.
The industrial production of CAS No. 272451-61-3 is one of the most sophisticated processes in agrochemical manufacturing. It requires the precise, sequential coupling of three distinct, high-value building blocks.
The major synthetic challenges include:
The synthesis requires forming two different amide bonds on the phthalic core. The first reaction involves the bulky heptafluoroisopropyl aniline, and the second introduces the sulfur-containing amine. Achieving high yields in these sterically hindered coupling steps is technically demanding.
Since Flubendiamide is a final AI, it must meet stringent regulatory standards for "Technical Grade" material (≥ 98% purity). Any trace impurities from the fluorinated or iodinated precursors can affect biological efficacy or environmental safety profiles.
The final product must be produced in a specific crystalline form to ensure stability in various formulations (e.g., suspension concentrates or water-dispersible granules).
Sourcing Flubendiamide requires a partner who can manage the entire supply chain—from the specialized intermediates to the final complex coupling.
The ideal supplier is one who manufactures the precursors (iodinated acid, fluorinated aniline, and sulfur amine) in-house to ensure the highest quality control and cost-efficiency.
The manufacturer must provide comprehensive data packages, including GLP-certified toxicity studies and five-batch analysis for global registration.
The ability to provide multi-ton quantities of stable, high-purity technical grade material is essential for global distribution partners.
The manufacturing of this "diamide" powerhouse is limited to elite players with massive technical infrastructure.
With an impressive and enduring legacy spanning over three decades of expertise within the specialized fine chemical sector, EASTFINE stands as a premier producer of Flubendiamide. Our unique advantage lies in our full vertical integration. For CAS 272451-61-3, EASTFINE offers:
Because we synthesize our own 3-iodophthalic acid and heptafluoroisopropyl aniline, we maintain absolute control over the impurities from the start, consistently delivering Flubendiamide with a purity of ≥ 99%.
We have optimized the complex sequential amidation process to minimize waste and maximize yield, ensuring a cost-competitive supply of this high-end insecticide.
EASTFINE provides the complete technical dossier required for international registrations, backed by ISO and cGMP-aligned quality management.
We offer secure, stable packaging designed to preserve the crystalline integrity of the product during international transit, ensuring it is ready for immediate formulation.
The original discoverer and patent holder of Flubendiamide. They set the global standard for quality and remain the primary innovator in the field, managing the product's life cycle and high-end global distribution.
As a major strategic partner in the commercialization of Flubendiamide, Bayer manages large-scale formulation and distribution. They are a benchmark for environmental safety standards and field-application expertise.
A key manufacturer of the essential intermediates and the technical grade active ingredient. They possess deep technical knowledge of the diamide scaffold and its synthesis at industrial scales.
While primarily a specialty chemical provider, Solvay’s mastery of the fluorinated components and specialized reagents makes them a critical partner in the high-end European supply chain for diamide-based crop protection.
When you source Flubendiamide from EASTFINE, you are not just buying a chemical; you are securing a high-performance solution backed by a master of the entire synthetic route.
Choosing EASTFINE means:
We control every step, from the first iodine atom to the final diamide bond.
Our high-purity technical grade material ensures that your final formulations perform consistently in the field, every time.
Our integrated approach allows us to offer premium quality with the efficiency required to compete in the global agrochemical market.
Flubendiamide (CAS No. 272451-61-3) remains one of the most effective and environmentally responsible tools for lepidopteran control. Its complex synthesis and high performance demand a supplier with technical depth and a commitment to quality. Partner with EASTFINE to secure a high-quality, integrated supply of this essential insecticide.
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