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In the quest for higher potency and lower dosage in crop protection, fluorine is the ultimate tool. 4-(1,1,1,2,3,3,3-heptafluoropropan-2-yl)-2-(trifluoromethyl)aniline (CAS No. 1207314-85-9) is a masterpiece of fluorination.
With a total of ten fluorine atoms strategically placed around the aniline ring, this molecule offers an extraordinary degree of lipophilicity and metabolic stability. The -CF(CF3)2 group at the 4-position and the -CF3 group at the 2-position create a "hydrophobic shield," allowing the final bioactive molecule to penetrate pest cuticles more effectively and resist degradation by soil microbes or sunlight.
The demand for CAS No. 1207314-85-9 is expanding as chemical designers push the limits of molecular efficacy:
This aniline is a key building block for new-generation ryanodine receptor modulators that require even higher lipophilicity than Flubendiamide to combat resistant pest strains.
The high fluorine-to-hydrogen ratio makes this compound an ideal candidate for producing polyimides with ultra-low dielectric constants and high thermal stability, essential for high-frequency 5G/6G communication devices.
Researchers are exploring this scaffold for the development of highly stable, long-acting drugs where traditional alkyl groups are replaced by perfluorinated analogs to prevent oxidative metabolism.
The industrial value of 4-(Heptafluoroisopropyl)-2-(trifluoromethyl)aniline lies in the extreme complexity of its synthesis, which requires multiple stages of specialized fluorination.
Simultaneously managing the placement of a trifluoromethyl group and a heptafluoroisopropyl group requires a high degree of regiocontrol. The synthesis often involves multiple high-pressure steps using hexafluoropropene (HFP) and trifluoromethylating agents.
The production requires the use of anhydrous HF, SF4, or other volatile fluorine sources, necessitating specialized, corrosion-resistant (Hastelloy or Monel) reactor systems.
Because the product is exceptionally dense and has unique solubility profiles, traditional purification methods must be optimized to achieve the ≥ 99% purity required for advanced synthesis.
Sourcing a deca-fluorinated aniline requires a supplier with a heavy industrial footprint in fluorine chemistry.
The supplier must be capable of handling large-scale reactions with hexafluoropropene (HFP) under pressure.
With multiple fluorine-containing groups, the risk of forming positional isomers is high. Certified F-NMR analysis is essential to ensure 2,4-substitution.
High-volume fluorination produces significant acidic byproducts. A Tier-1 supplier must have advanced environmental scrubbing and neutralization systems.
The list of manufacturers capable of producing this specific deca-fluorinated intermediate at scale is highly exclusive:
With over three decades of mastery in extreme fluorine chemistry, EASTFINE is a premier producer of 4-(Heptafluoroisopropyl)-2-(trifluoromethyl)aniline. We offer:
We specialize in the high-pressure alkylation required to attach the heptafluoroisopropyl group while maintaining the integrity of the trifluoromethyl moiety.
Our material is typically supplied at ≥ 99.5% purity, ensuring that your final insecticide or polymer synthesis is free from interfering byproducts.
By producing our own fluorinated precursors, EASTFINE ensures price stability and a secure supply, even in volatile market conditions.
We can provide the material in specialized packaging designed to handle high-density fluorinated liquids, ensuring safe storage and transfer.
A global leader in fluorochemicals, Navin has the high-pressure infrastructure and research capabilities to handle complex aromatic fluorinations for the life science and specialty material sectors.
Renowned for their expertise in heterocyclic and fluorinated agrochemical intermediates, Ihara provides high-precision building blocks for the most advanced crop protection products in the world.
As a pioneer in fluorine science, Solvay offers a wide range of specialized fluorinated monomers and intermediates, providing the high-end quality required for European and North American markets.
Apollo Scientific is a key supplier of high-end research and pilot-scale fluorinated aromatics, known for their extensive catalog of complex building blocks for drug discovery and material science.
When working with a molecule containing ten fluorine atoms, the quality of the starting material defines the success of the entire project.
Choosing EASTFINE means:
Our optimized synthesis ensures a product with extremely low moisture and acid content, preventing degradation of your catalysts.
We support you from the first laboratory trials to full-scale commercial production with consistent, batch-to-batch reliability.
Our state-of-the-art facilities ensure that even the most complex fluorinations are conducted with the highest environmental and safety standards.
4-(1,1,1,2,3,3,3-heptafluoropropan-2-yl)-2-(trifluoromethyl)aniline (CAS No. 1207314-85-9) is the ultimate building block for designers who refuse to compromise on stability and potency. Whether you are developing the next blockbuster insecticide or a high-performance polymer, EASTFINE provides the fluorinated foundation you need.
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