Top 10 Manufacturers of Pharmaceutical Intermediate CAS No. 951-82-6 in 2025

Understanding CAS No. 951-82-6 – A Key Intermediate for Antipsychotic and CNS Drugs

CAS No. 951-82-6, chemically known as 2-Methoxy-5-nitroaniline, is a versatile aromatic intermediate widely used in the synthesis of central nervous system (CNS) drugs, particularly in the production of antipsychotic and antidepressant agents. Due to its reactive nitro and amine groups, it serves as a foundational building block in the formation of more complex heterocyclic compounds.

Its utility in both branded and generic drug manufacturing makes it a sought-after intermediate in regulated pharmaceutical markets across North America, Europe, and Asia.

Importance of CAS No. 951-82-6 in Pharmaceutical Manufacturing

Crucial for CNS-Active Drug Synthesis

Frequently used in multi-step processes to create tricyclic and heterocyclic psychotropic drug molecules.

Highly Functionalized Aromatic Precursor

Its combination of nitro and amino groups allows selective downstream reactions.

Widely Used in Antipsychotic APIs

Intermediate in the production of key APIs for schizophrenia, bipolar disorder, and depression.

Industrial-Scale Manufacturing Ready

Stable and scalable for high-volume production under cGMP standards.

Global Regulatory Acceptance

Manufactured under strict guidelines to support export to the US, EU, and emerging markets.

Top 10 Manufacturers of CAS No. 951-82-6

1. Vertellus

• Location: Indianapolis, Indiana, USA

• Overview: Known for its strong catalog of nitroaromatic and aniline derivatives for pharmaceutical use.

• Specialty: Expertise in electron-rich aromatic intermediates and high-purity specifications.

2. Farmhispania Group

• Location: Barcelona, Spain

• Overview: European supplier focused on CNS drug intermediates and custom synthesis solutions.

• Specialty: EU-GMP certified with flexible scale-up for clinical and commercial needs.

3. Eastfine

• Location: Changzhou City, Jiangsu Province, China

• Overview: Reliable and experienced exporter of 2-Methoxy-5-nitroaniline for CNS-targeted APIs.

• Specialty: High consistency in product quality, compliance with global pharma standards.

4. Aarti Pharmalabs

• Location: Maharashtra, India

• Overview: Major Indian supplier of aromatic and nitro intermediates, catering to global pharmaceutical companies.

• Specialty: Backward integrated manufacturing with robust QC and documentation systems.

5. WeylChem International

• Location: Frankfurt, Germany

• Overview: Specialty chemicals division with advanced capabilities in aromatic substitution chemistry.

• Specialty: Custom synthesis and toll manufacturing under strict QA/QC systems.

6. Jubilant Ingrevia

• Location: Uttar Pradesh, India

• Overview: Large-scale producer of halogenated and nitrated anilines for use in CNS and cardiovascular drugs.

• Specialty: Process safety and environmental control for regulated markets.

7. Neuland Laboratories

• Location: Hyderabad, India

• Overview: Focused on intermediates and APIs for CNS, cardiovascular, and anti-infective categories.

• Specialty: Strong regulatory history with USFDA and EMA inspections.

8. Sterling Pharma Solutions

• Location: Newcastle, UK

• Overview: Custom API and intermediate manufacturer with capabilities in nitro reduction and amine chemistry.

• Specialty: High-potency chemistry and fully integrated analytical services.

9. Delmar Chemicals

• Location: Montreal, Canada

• Overview: Offers aromatic intermediates for small-molecule API development, particularly CNS therapeutics.

• Specialty: Batch scale flexibility and full regulatory documentation support.

10. Curia Global (formerly AMRI)

• Location: Albany, New York, USA

• Overview: Contract manufacturer with established track record in specialty intermediates and CNS-related APIs.

• Specialty: Route optimization, impurity control, and commercial readiness.

Trends in the Pharmaceutical Intermediates Market

Rising Prevalence of Mental Health Disorders

The global mental health crisis is fueling demand for antipsychotic and antidepressant medications, increasing intermediate production.

Advanced Aromatic Chemistry for CNS APIs

Intermediates like CAS 951-82-6 are essential for complex aromatic scaffolds in neuroactive drugs.

Regulatory Emphasis on Nitrogen-Containing Compounds

Agencies demand strict residual solvent and impurity control in nitroaniline-based intermediates.

Sustainability in Nitration Processes

Manufacturers are adopting eco-friendly nitration methods and minimizing hazardous waste.

Increased Outsourcing to Specialized Manufacturers

Pharma companies are relying more on CDMOs and global suppliers for non-core intermediate manufacturing.

Conclusion

CAS No. 951-82-6, or 2-Methoxy-5-nitroaniline, is a pivotal intermediate in the synthesis of CNS drugs and psychotropic medications. Suppliers such as Eastfine, Vertellus, Farmhispania, and Aarti Pharmalabs lead the global market in providing high-quality, compliant material for the world’s growing mental health treatment needs.

With rising demand and tighter regulatory expectations, the role of experienced, quality-focused intermediate manufacturers is more critical than ever.