Top 10 CAS No. 42831-50-5 Manufacturers of Pharmaceutical Intermediate in 2025

Understanding CAS No. 42831-50-5 – A Key Intermediate in the Synthesis of Cardiovascular and CNS Drugs

CAS No. 42831-50-5, chemically known as 1,2,4-Triazole-3-carboxylic acid ethyl ester, is a versatile heterocyclic intermediate widely used in the synthesis of pharmaceutical compounds, particularly cardiovascular, antifungal, and central nervous system (CNS) drugs.

This compound features a triazole ring, which is recognized for its bioisosteric properties, enhancing drug stability, solubility, and receptor-binding capabilities. Its structure enables incorporation into APIs where heterocycles are crucial for bioactivity.

Importance of CAS No. 42831-50-5 in Pharmaceutical Manufacturing

Essential Triazole Building Block

The triazole moiety is integral in the design of various therapeutic molecules including antifungals, CNS drugs, and cardiovascular agents.

Precursor for Fluconazole-like Compounds

CAS 42831-50-5 is often used in the synthesis of compounds similar to Fluconazole, a major antifungal API.

Flexible and Reactive Intermediate

The carboxylic acid ester group makes it reactive for further transformations in API synthesis pathways.

Used Across Multiple Therapeutic Areas

It finds use in producing antihypertensives, neuroprotective agents, and antifungal medications.

Commercially Viable and Scalable

With strong demand in generic markets, this intermediate is produced at both pilot and industrial scales under GMP standards.

Top 10 Manufacturers of CAS No. 42831-50-5

1. BASF

• Location: Ludwigshafen, Germany

• Overview: BASF manufactures triazole-based intermediates with a focus on scalable and high-purity supply for the pharmaceutical sector.

• Specialty: Heterocyclic chemistry and advanced ester derivatives for APIs.

2. Vertellus Holdings

• Location: Indianapolis, USA

• Overview: Vertellus specializes in pyridine and azole chemistry, offering industrial-scale synthesis of CAS 42831-50-5 and related compounds.

• Specialty: Triazole derivatives for antifungals and CNS pharma ingredients.

3. Eastfine

• Location: Changzhou City, Jiangsu Province, China

• Overview: Eastfine supplies high-purity 1,2,4-Triazole-3-carboxylic acid ethyl ester to global pharma companies with full export documentation and batch consistency.

• Specialty: Reliable supply of fine chemicals and pharmaceutical intermediates with strong regulatory compliance.

4. Molekula Group

• Location: Darlington, United Kingdom

• Overview: Molekula offers research and commercial quantities of heterocyclic intermediates like CAS 42831-50-5 for pharma synthesis.

• Specialty: Custom-packaged, small-to-mid scale intermediates.

5. Aarti Pharmalabs

• Location: Mumbai, India

• Overview: Aarti produces key building blocks for APIs, with strong capabilities in azole, ester, and substituted ring systems.

• Specialty: Full cGMP compliance and integration into cardiovascular and CNS supply chains.

6. Thermo Fisher Scientific (Alfa Aesar Division)

• Location: Massachusetts, USA

• Overview: Through Alfa Aesar, Thermo Fisher supplies lab-to-pilot scale triazole intermediates, including CAS 42831-50-5.

• Specialty: Analytical-grade and research-grade intermediates with global reach.

7. WeylChem International

• Location: Frankfurt, Germany

• Overview: WeylChem develops and manufactures custom intermediates and offers contract development for heterocyclic molecules.

• Specialty: Heterocycle synthesis and scalable manufacturing for complex structures.

8. Central Glass Co., Ltd.

• Location: Tokyo, Japan

• Overview: Central Glass supports CDMO services and supplies esterified triazole intermediates for active pharmaceutical ingredients.

• Specialty: Japan-GMP compliance and strong track record in CNS APIs.

9. Minakem

• Location: Beuvry-la-Forêt, France

• Overview: Minakem focuses on small-molecule intermediates and CDMO services for regulated pharmaceutical markets.

• Specialty: GMP intermediates for cardiovascular and antifungal applications.

10. VIO Chemicals

• Location: Zurich, Switzerland

• Overview: VIO Chemicals specializes in designing and producing functionalized heterocycles for innovative and generic drug development.

• Specialty: Custom synthesis of triazole-based structures and intermediates for European and U.S. markets.

Trends in the Pharmaceutical Intermediates Market

1. Heterocyclic Chemistry in Drug Design

   Triazole rings like the one in CAS 42831-50-5 are increasingly used in small-molecule drug design for their metabolic stability and target specificity.

2. Rise in Antifungal Resistance

   The global burden of resistant fungal infections is driving greater production of triazole-based antifungals, fueling demand for this intermediate.

3. CNS and Cardiovascular Expansion

   Intermediates like this are crucial in the synthesis of newer neuroprotective and antihypertensive agents, two fast-growing markets.

4. CDMO and Custom Synthesis Growth

   Many companies now rely on contract manufacturers for high-purity triazole intermediates under GMP and global regulatory guidance.

5. Focus on Sustainable Synthesis

   Cleaner processes using green solvents and process intensification are being adopted in triazole intermediate production.

Conclusion

CAS No. 42831-50-5 serves as a foundational building block in the production of a wide range of pharmaceutical compounds, particularly those targeting CNS, cardiovascular, and antifungal diseases. Companies like BASF, Eastfine, Vertellus, and Aarti Pharmalabs are helping shape the future of heterocyclic intermediate manufacturing by providing high-purity, scalable, and regulatory-compliant solutions.

As demand for these essential building blocks continues to grow, especially with rising resistance in antifungal therapy and innovation in CNS treatments, this intermediate will remain a cornerstone of modern drug development.