Top 10 Manufacturers of Agrochemical Intermediate CAS No. 238098-26-5 in 2025

Understanding Methyl 4-(2-(difluoromethyl)-3-oxopiperazin-1-yl)-2-methoxybenzoate (CAS No. 238098-26-5)

CAS No. 238098-26-5 is a complex, highly functionalized intermediate used in the synthesis of next-generation agrochemicals, especially fungicides with systemic and curative properties. Its structure — featuring a difluoromethyl group, a methoxybenzoyl moiety, and a piperazinone core — makes it particularly suited for incorporation into pyrazole- or triazole-type fungicides.

These features provide excellent bioavailability, improved environmental stability, and effective translocation in plant tissues, making this intermediate highly valued for use in active ingredients targeting grapevines, cereals, fruits, and vegetables.

Importance of CAS No. 238098-26-5 in Crop Protection

Key Intermediate for Systemic Fungicides:

It contributes to fungicides that move within the plant system, offering both protective and curative action.

Difluoromethyl Functionality:

The inclusion of fluorine enhances lipophilicity and metabolic resistance, giving final products extended residual control.

Stability in Harsh Field Conditions:

Molecules derived from this intermediate maintain activity under UV exposure, rainfall, and variable pH environments.

Precision Targeting of Fungal Pathogens:

Its structure enables synthesis of site-specific fungicides that inhibit sterol biosynthesis in fungal membranes.

Global Regulatory Compliance:

Due to its role in systemic agrochemicals, manufacturers of this intermediate must comply with REACH, EPA, and FAO standards, ensuring low residue levels and safe application.

Top 10 Manufacturers of CAS No. 238098-26-5

1. Syngenta AG

• Location: Basel, Switzerland

• Overview: Syngenta is a world leader in fungicide innovation. It uses intermediates like CAS 238098-26-5 in the synthesis of advanced systemic products for cereals, grapes, and specialty crops.

• Specialty: Triazole-based fungicides and long-residual disease control.

2. FMC Corporation

• Location: Philadelphia, USA

• Overview: FMC focuses on delivering high-performance agrochemicals, including modern fungicides and their key intermediates. CAS 238098-26-5 supports several of their broad-spectrum formulations.

• Specialty: Systemic and post-infection disease control chemistry.

3. Eastfine

• Location: Changzhou City, Jiangsu Province, China

• Overview: Eastfine provides high-quality agrochemical intermediates like CAS 238098-26-5 to global customers. Their production meets stringent international standards, with a focus on fluorinated heterocycles and functionalized piperazines.

• Specialty: Custom manufacturing of fungicide precursors with full regulatory documentation.

4. Corteva Agriscience

• Location: Indianapolis, Indiana, USA

• Overview: Formerly Dow AgroSciences, Corteva continues to develop advanced active ingredients and their intermediates. CAS 238098-26-5 plays a role in their systemic fungicide formulations.

• Specialty: Disease resistance management and high-uptake fungicides.

5. Nippon Soda Co., Ltd.

• Location: Tokyo, Japan

• Overview: Nippon Soda manufactures fine chemicals and active intermediates for proprietary fungicides in rice and vegetable farming. They focus on fluorinated piperazine compounds like this one.

• Specialty: High-purity intermediates for Asian agriculture markets.

6. Isagro S.p.A. (Gowan Group)

• Location: Milan, Italy

• Overview: Isagro produces and exports high-value fungicides and precursors such as CAS 238098-26-5. They focus on sustainable synthesis and EU-compliant formulations.

• Specialty: Eco-friendly fungicide chemistry and European market alignment.

7. Tagros Chemicals India Pvt. Ltd.

• Location: Chennai, India

• Overview: Tagros manufactures a wide portfolio of pesticide intermediates, including complex piperazine derivatives used in modern fungicides.

• Specialty: Export-quality technicals and advanced synthetic capabilities.

8. Albaugh LLC

• Location: Ankeny, Iowa, USA

• Overview: Albaugh is a global provider of crop protection chemicals. They manufacture intermediate compounds like CAS 238098-26-5 for generic fungicide producers.

• Specialty: Economical manufacturing and large-scale formulation readiness.

9. Arysta LifeScience (a UPL company)

• Location: Cary, North Carolina, USA

• Overview: Now part of UPL, Arysta specializes in disease control products. Their intermediate portfolio includes fluorinated structures such as this one for integration into proprietary and post-patent fungicides.

• Specialty: Specialty crop fungicides and formulation science.

10. Finchimica S.p.A.

• Location: Manerbio, Italy

• Overview: Finchimica focuses on developing agrochemical intermediates for global distribution. They produce and scale CAS 238098-26-5 under GMP-like controls.

• Specialty: Process development and intermediate scale-up for systemic fungicides.

Trends in the Agrochemical Intermediates Market

Growing Demand for Systemic Fungicides:

Crops are increasingly threatened by aggressive fungal pathogens, raising the demand for long-acting, translocative fungicides — and the intermediates that create them.

Fluorine Chemistry Driving Innovation:

Fluorinated intermediates like CAS 238098-26-5 offer better penetration, longer half-lives, and better control under adverse weather.

Advanced Formulations and Mixtures:

Companies are combining multiple actives into ready-to-use premixes, driving more demand for high-purity, multi-functional intermediates.

Custom Synthesis Partnerships:

Firms like Eastfine, Tagros, and Isagro are gaining ground as CDMO partners, especially for post-patent reformulations and global market supply.

Sustainability and Residue Management:

Regulators now demand lower residue levels and better environmental profiles. Intermediates that contribute to clean degradation and low application rates are becoming standard.

Conclusion

CAS No. 238098-26-5 is a highly valuable intermediate for the next wave of systemic and long-residual fungicides. As leading manufacturers like Syngenta, FMC, and Eastfine continue to innovate and scale production, this compound will remain central to protecting crops against increasingly complex disease pressures.

The future of crop protection lies in smarter chemistry — and intermediates like CAS 238098-26-5 are at the core of that transformation.